Early results of autologous chondrocyte implantation in the talus.

Autologous chondrocyte implantation (ACI) has been used most commonly as a treatment for cartilage defects in the knee and there are few studies of its use in other joints. We describe ten patients with an osteochondral lesion of the talus who underwent ACI using cartilage taken from the knee and were prospectively reviewed with a mean follow-up of 23 months. In nine patients the satisfaction score was 'pleased' or 'extremely pleased', which was sustained at four years. The mean Mazur ankle score increased by 23 points at a mean follow-up of 23 months. The Lysholm knee score returned to the pre-operative level at one year in three patients, with the remaining seven showing a reduction of 15% at 12 months, suggesting donor-site morbidity. Nine patients underwent arthroscopic examination at one year and all were shown to have filled defects and stable cartilage. Biopsies taken from graft sites showed mostly fibrocartilage with some hyaline cartilage. The short-term results of ACI for osteochondral lesions of the talus are good despite some morbidity at the donor site.

[1]  T. Briggs,et al.  Histological evaluation of chondral defects after autologous chondrocyte implantation of the knee. , 2003, The Journal of bone and joint surgery. British volume.

[2]  D. Robinson,et al.  ARTHROSCOPIC TREATMENT OF OSTEOCHONDRAL LESIONS OF THE TALUS , 2016, Acta ortopedica brasileira.

[3]  M. Brittberg,et al.  Autologous chondrocyte transplantation of the ankle. , 2003, Foot and ankle clinics.

[4]  P. Bullough,et al.  Histological Assessment of Cartilage Repair: A Report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS) , 2003, The Journal of bone and joint surgery. American volume.

[5]  Sally Roberts,et al.  Autologous chondrocyte implantation for cartilage repair: monitoring its success by magnetic resonance imaging and histology , 2002, Arthritis research & therapy.

[6]  M. Myerson,et al.  Approach alternatives for treatment of osteochondral lesions of the talus. , 2002, Foot and ankle clinics.

[7]  R. Jakob,et al.  Treatment of cartilage defects of the talus by autologous osteochondral grafts. , 2002, The Journal of bone and joint surgery. British volume.

[8]  L. L. Johnson.  Arthroscopic Abrasion Arthroplasty: A Review , 2001, Clinical orthopaedics and related research.

[9]  L. Hangody,et al.  Mosaicplasty for the Treatment of Osteochondritis Dissecans of the Talus: Two to Seven Year Results in 36 Patients , 2001, Foot & ankle international.

[10]  F. Vannini,et al.  Autologous Chondrocyte Transplantation in Osteochondral Lesions of the Ankle Joint , 2001, Foot & ankle international.

[11]  M. Brittberg,et al.  Two- to 9-Year Outcome After Autologous Chondrocyte Transplantation of the Knee , 2000, Clinical orthopaedics and related research.

[12]  P. Bossuyt,et al.  Treatment Strategies in Osteochondral Defects of the Talar Dome: a Systematic Review , 2000, Foot & ankle international.

[13]  Y. Takakura,et al.  Arthroscopic drilling for the treatment of osteochondral lesions of the talus. , 1999, The Journal of bone and joint surgery. American volume.

[14]  C. Ohlsson,et al.  Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. , 1994, The New England journal of medicine.

[15]  T. Yamamuro,et al.  Arthroscopic multiple osteochondral transplantation to the chondral defect in the knee associated with anterior cruciate ligament disruption. , 1993, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[16]  J. Lysholm,et al.  Rating systems in the evaluation of knee ligament injuries. , 1985, Clinical orthopaedics and related research.

[17]  R. Ficat,et al.  Spongialization: a new treatment for diseased patellae. , 1979, Clinical orthopaedics and related research.

[18]  S. Simon,et al.  Ankle arthrodesis. Long-term follow-up with gait analysis. , 1979, The Journal of bone and joint surgery. American volume.

[19]  J. Richardson,et al.  The in Vitro Growth of Human Chondrocytes , 2004, Cell and Tissue Banking.

[20]  V. Pinskerova,et al.  Should the cement mantle around the femoral component be thick or thin? , 2003, The Journal of bone and joint surgery. British volume.

[21]  K. Jonsson,et al.  Osteochondritis dissecans of the ankle. A 20-year follow-up study. , 1987, The Journal of bone and joint surgery. British volume.

[22]  P. Kinnunen,et al.  Reconstruction of the joint surface using osteochondral fragments. An experimental and clinical study. , 1982, Scandinavian journal of rheumatology. Supplement.

[23]  S. Canale,et al.  Osteochondral lesions of the talus. , 1980, The Journal of bone and joint surgery. American volume.