Bone composition: relationship to bone fragility and antiosteoporotic drug effects.

[1]  P. Pietschmann,et al.  Intravenous Treatment With Ibandronate Normalizes Bone Matrix Mineralization and Reduces Cortical Porosity After Two Years in Male Osteoporosis: A Paired Biopsy Study , 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[2]  A. Boskey,et al.  Mineralized Tissue: Histology, Biology and Biochemistry , 2014 .

[3]  A. Evdokiou,et al.  Calcium induces pro-anabolic effects on human primary osteoblasts associated with acquisition of mature osteocyte markers , 2013, Molecular and Cellular Endocrinology.

[4]  M. Tamura,et al.  Wasf2: a novel target of intermittent parathyroid hormone administration. , 2013, International journal of molecular medicine.

[5]  M. Bouxsein,et al.  Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[6]  R. Recker,et al.  Annual intravenous zoledronic acid for three years increased cancellous bone matrix mineralization beyond normal values in the HORIZON biopsy cohort , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[7]  V. Gun'ko,et al.  Textural characteristics of model and natural bone tissues and interfacial behavior of bound water. , 2013, Journal of colloid and interface science.

[8]  A. Boskey,et al.  Fourier Transform Infrared Spectroscopic Imaging Parameters Describing Acid Phosphate Substitution in Biologic Hydroxyapatite , 2013, Calcified Tissue International.

[9]  S. Adeeb,et al.  Compositional and material properties of rat bone after bisphosphonate and/or Strontium ranelate drug treatment. , 2013, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[10]  E. McCloskey,et al.  Analysis of Body Composition in Individuals With High Bone Mass Reveals a Marked Increase in Fat Mass in Women But Not Men , 2013, The Journal of clinical endocrinology and metabolism.

[11]  N. Fuku,et al.  Association of the formiminotransferase N-terminal sub-domain containing gene and thrombospondin, type 1, domain-containing 7A gene with the prevalence of vertebral fracture in 2427 consecutive autopsy cases , 2013, Journal of Human Genetics.

[12]  A. Boskey,et al.  Fourier transform infrared imaging of femoral neck bone: Reduced heterogeneity of mineral‐to‐matrix and carbonate‐to‐phosphate and more variable crystallinity in treatment‐naive fracture cases compared with fracture‐free controls , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[13]  H. Chong,et al.  Load-bearing in cortical bone microstructure: Selective stiffening and heterogeneous strain distribution at the lamellar level. , 2013, Journal of the mechanical behavior of biomedical materials.

[14]  L. Duong,et al.  Effects of Odanacatib on Bone Mineralization Density Distribution in Thoracic Spine and Femora of Ovariectomized Adult Rhesus Monkeys: A Quantitative Backscattered Electron Imaging Study , 2013, Calcified Tissue International.

[15]  G. Boivin,et al.  Effects of strontium on the quality of bone apatite crystals: a paired biopsy study in postmenopausal osteoporotic women , 2013, Osteoporosis International.

[16]  P. Fratzl,et al.  Bone material properties in premenopausal women with idiopathic osteoporosis , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[17]  W. Leslie.  Clinical review: Ethnic differences in bone mass--clinical implications. , 2012, The Journal of clinical endocrinology and metabolism.

[18]  N. Karamanos,et al.  The Biology of Small Leucine-rich Proteoglycans in Bone Pathophysiology* , 2012, The Journal of Biological Chemistry.

[19]  R. Brooks,et al.  Lipids in biocalcification: contrasts and similarities between intimal and medial vascular calcification and bone by NMR[S] , 2012, Journal of Lipid Research.

[20]  M. Dean,et al.  Comparison of structural, architectural and mechanical aspects of cellular and acellular bone in two teleost fish , 2012, Journal of Experimental Biology.

[21]  A. Boskey,et al.  Bone tissue composition varies across anatomic sites in the proximal femur and the iliac crest , 2012, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[22]  D. Vashishth,et al.  Effects of Bone Matrix Proteins on Fracture and Fragility in Osteoporosis , 2012, Current Osteoporosis Reports.

[23]  Daniel L. Koller,et al.  Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture , 2012, Nature Genetics.

[24]  E. Shimizu,et al.  Alendronate Affects Osteoblast Functions by Crosstalk through EphrinB1-EphB , 2012, Journal of dental research.

[25]  D. Lorich,et al.  Reduced cortical bone compositional heterogeneity with bisphosphonate treatment in postmenopausal women with intertrochanteric and subtrochanteric fractures , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[26]  H. Malluche,et al.  Differences in bone quality in low- and high-turnover renal osteodystrophy. , 2012, Journal of the American Society of Nephrology : JASN.

[27]  D. Felsenberg,et al.  Impact of oral ibandronate 150 mg once monthly on bone structure and density in post-menopausal osteoporosis or osteopenia derived from in vivo μCT. , 2012, Bone.

[28]  R. Recker,et al.  Effects of 3 years treatment with once-yearly zoledronic acid on the kinetics of bone matrix maturation in osteoporotic patients , 2012, Osteoporosis International.

[29]  Sharmila Majumdar,et al.  Noninvasive imaging of bone microarchitecture , 2011, Annals of the New York Academy of Sciences.

[30]  E. Paschalis,et al.  Effects of one year daily teriparatide treatment on trabecular bone material properties in postmenopausal osteoporotic women previously treated with alendronate or risedronate. , 2011, Bone.

[31]  P. Zysset,et al.  Lathyrism-induced alterations in collagen cross-links influence the mechanical properties of bone material without affecting the mineral , 2011, Bone.

[32]  J. Pasteris,et al.  Structural Water in Carbonated Hydroxylapatite and Fluorapatite: Confirmation by Solid State 2H NMR , 2011, Calcified Tissue International.

[33]  P. Meunier,et al.  Distribution of strontium and mineralization in iliac bone biopsies from osteoporotic women treated long-term with strontium ranelate. , 2011, European journal of endocrinology.

[34]  Michael D Morris,et al.  Raman Assessment of Bone Quality , 2011, Clinical orthopaedics and related research.

[35]  K. Jepsen.  Functional Interactions Among Morphologic and Tissue Quality Traits Define Bone Quality , 2011, Clinical orthopaedics and related research.

[36]  A. Frigessi,et al.  Molecular disease map of bone characterizing the postmenopausal osteoporosis phenotype , 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[37]  M. Fukagawa,et al.  Changes in chemical composition of cortical bone associated with bone fragility in rat model with chronic kidney disease. , 2011, Bone.

[38]  T. Hefferan,et al.  COL1 C‐propeptide cleavage site mutations cause high bone mass osteogenesis imperfecta , 2011, Human mutation.

[39]  H. Helminen,et al.  Comparison between Infrared and Raman Spectroscopic Analysis of Maturing Rabbit Cortical Bone , 2011, Applied spectroscopy.

[40]  D. Vashishth,et al.  Biochemical Characterization of Major Bone-Matrix Proteins Using Nanoscale-Size Bone Samples and Proteomics Methodology* , 2011, Molecular & Cellular Proteomics.

[41]  E. Fischer,et al.  Severe osteoporosis with multiple vertebral fractures after gender reassignment therapy – is it male or female osteoporosis? , 2011, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.

[42]  Steve D. M. Brown,et al.  Genome-Wide Association Study Using Extreme Truncate Selection Identifies Novel Genes Affecting Bone Mineral Density and Fracture Risk , 2011, PLoS genetics.

[43]  Sandra J Shefelbine,et al.  Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties. , 2011, Blood.

[44]  R. Recker,et al.  Bone material properties in actively bone‐forming trabeculae in postmenopausal women with osteoporosis after three years of treatment with once‐yearly Zoledronic acid , 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[45]  M. Saito,et al.  Changes in the contents of enzymatic immature, mature, and non-enzymatic senescent cross-links of collagen after once-weekly treatment with human parathyroid hormone (1–34) for 18 months contribute to improvement of bone strength in ovariectomized monkeys , 2011, Osteoporosis International.

[46]  Toshitaka Nakamura,et al.  Lower osteocalcin and osteopontin contents of the femoral head in hip fracture patients than osteoarthritis patients , 2011, Osteoporosis International.

[47]  Y. Cheng,et al.  Osteopontin regulates anabolic effect in human menopausal osteoporosis with intermittent parathyroid hormone treatment , 2011, Osteoporosis International.

[48]  A. Boskey,et al.  Aging and Bone , 2010, Journal of dental research.

[49]  Sharmila Majumdar,et al.  A Longitudinal HR-pQCT Study of Alendronate Treatment in Postmenopausal Women With Low Bone Density: Relations Among Density, Cortical and Trabecular Microarchitecture, Biomechanics, and Bone Turnover , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[50]  J. Jurvelin,et al.  Infrared spectroscopy indicates altered bone turnover and remodeling activity in renal osteodystrophy , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[51]  S. Seino,et al.  Alendronate induces mineralization in mouse osteoblastic MC3T3-E1 cells: regulation of mineralization-related genes. , 2010, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

[52]  D. Burr,et al.  Bisphosphonate treatment modifies canine bone mineral and matrix properties and their heterogeneity. , 2010, Bone.

[53]  F. Glorieux,et al.  CRTAP deficiency leads to abnormally high bone matrix mineralization in a murine model and in children with osteogenesis imperfecta type VII. , 2010, Bone.

[54]  W. Fan,et al.  Structural and cellular features in metaphyseal and diaphyseal periosteum of osteoporotic rats , 2010, Journal of Molecular Histology.

[55]  P. Fratzl,et al.  Mineralization density distribution of postmenopausal osteoporotic bone is restored to normal after long‐term alendronate treatment: qBEI and sSAXS data from the fracture intervention trial long‐term extension (FLEX) , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[56]  P. Fratzl,et al.  Bone material quality in transiliac bone biopsies of postmenopausal osteoporotic women after 3 years of strontium ranelate treatment , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[57]  H. Zentgraf,et al.  Circulating fibronectin affects bone matrix, whereas osteoblast fibronectin modulates osteoblast function , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[58]  M. Bouxsein,et al.  Quantifying the material and structural determinants of bone strength. , 2009, Best practice & research. Clinical rheumatology.

[59]  Yurii S. Aulchenko,et al.  Twenty bone mineral density loci identified by large-scale meta-analysis of genome-wide association studies , 2009, Nature Genetics.

[60]  R. Recker,et al.  Use of FTIR Spectroscopic Imaging to Identify Parameters Associated With Fragility Fracture , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[61]  A. Boskey,et al.  Spatial Variation in Osteonal Bone Properties Relative to Tissue and Animal Age , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[62]  F. Jakob,et al.  Pulse treatment with zoledronic acid causes sustained commitment of bone marrow derived mesenchymal stem cells for osteogenic differentiation. , 2009, Bone.

[63]  P. Delmas,et al.  Bone microdamage: a clinical perspective , 2009, Osteoporosis International.

[64]  Yan Guo,et al.  Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups. , 2009, American journal of human genetics.

[65]  Mary B Leonard,et al.  Cortical bone water: in vivo quantification with ultrashort echo-time MR imaging. , 2008, Radiology.

[66]  M. Singer,et al.  Isoform of Fibronectin Mediates Bone Loss in Patients With Primary Biliary Cirrhosis by Suppressing Bone Formation , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[67]  Hidenori Sato,et al.  Association of genetic variations of genes encoding thrombospondin, type 1, domain-containing 4 and 7A with low bone mineral density in Japanese women with osteoporosis , 2008, Journal of Human Genetics.

[68]  F. Reinholt,et al.  Altered osteoclast development and function in osteopontin deficient mice , 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[69]  D. Burr,et al.  The effect of the microscopic and nanoscale structure on bone fragility , 2008, Osteoporosis International.

[70]  P. Fratzl,et al.  Bone mineralization density distribution in health and disease. , 2008, Bone.

[71]  S. Boonen,et al.  Effects of Intravenous Zoledronic Acid Once Yearly on Bone Remodeling and Bone Structure , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[72]  D. McMahon,et al.  Osteonectin/SPARC polymorphisms in Caucasian men with idiopathic osteoporosis , 2008, Osteoporosis International.

[73]  P. Delmas,et al.  Bisphosphonates alter trabecular bone collagen cross-linking and isomerization in beagle dog vertebra , 2008, Osteoporosis International.

[74]  S. Evans,et al.  Osteopenia in Sparc (osteonectin)-deficient mice: characterization of phenotypic determinants of femoral strength and changes in gene expression. , 2007, Physiological genomics.

[75]  A. Boskey,et al.  Mineralization of Bones and Teeth , 2007 .

[76]  D. Dempster,et al.  Increased resorptive activity and accompanying morphological alterations in osteoclasts derived from the oim/oim mouse model of osteogenesis imperfecta , 2007, Journal of cellular biochemistry.

[77]  D. Vashishth.  The role of the collagen matrix in skeletal fragility , 2007, Current Osteoporosis Reports.

[78]  Alessandro Armini,et al.  Differential expression of both extracellular and intracellular proteins is involved in the lethal or nonlethal phenotypic variation of BrtlIV, a murine model for osteogenesis imperfecta , 2007, Proteomics.

[79]  J. Simmer,et al.  Hereditary Dentin Defects , 2007, Journal of dental research.

[80]  Ling-Ling Zhu,et al.  Induction of a program gene expression during osteoblast differentiation with strontium ranelate. , 2007, Biochemical and biophysical research communications.

[81]  William F. Finney,et al.  Bone tissue compositional differences in women with and without osteoporotic fracture. , 2006, Bone.

[82]  P. Fratzl,et al.  Bone osteonal tissues by Raman spectral mapping: orientation-composition. , 2006, Journal of structural biology.

[83]  P. Fratzl,et al.  Bone Material Properties in Trabecular Bone From Human Iliac Crest Biopsies After 3‐ and 5‐Year Treatment With Risedronate , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[84]  P. Fratzl,et al.  Effects of 3‐ and 5‐Year Treatment With Risedronate on Bone Mineralization Density Distribution in Triple Biopsies of the Iliac Crest in Postmenopausal Women , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[85]  A. Boskey.  Assessment of bone mineral and matrix using backscatter electron imaging and FTIR imaging , 2006, Current osteoporosis reports.

[86]  W. Cole,et al.  Noncollagenous proteins in normal and pathological human bone , 1984, Calcified Tissue International.

[87]  M. Noda,et al.  Histological evidence of the altered distribution of osteocytes and bone matrix synthesis in klotho-deficient mice. , 2005, Archives of histology and cytology.

[88]  P. Sarathchandra,et al.  Enzyme histochemical localisation of alkaline phosphatase activity in osteogenesis imperfecta bone and growth plate: a preliminary study. , 2005, Micron.

[89]  P. Odetti,et al.  Advanced Glycation End Products and Bone Loss during Aging , 2005, Annals of the New York Academy of Sciences.

[90]  Richard Mendelsohn,et al.  Infrared analysis of bone in health and disease. , 2005, Journal of biomedical optics.

[91]  Georges Boivin,et al.  Infrared imaging of calcified tissue in bone biopsies from adults with osteomalacia. , 2005, Bone.

[92]  A. Boskey,et al.  Bone Fragility and Collagen Cross‐Links , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[93]  M. Kassem,et al.  Effect of Hormone Replacement Therapy on Bone Quality in Early Postmenopausal Women , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[94]  M. Young.  Bone matrix proteins: their function, regulation, and relationship to osteoporosis , 2003, Osteoporosis International.

[95]  P. Fratzl,et al.  Constant mineralization density distribution in cancellous human bone. , 2003, Bone.

[96]  K. Wennerberg,et al.  Polymerization of Type I and III Collagens Is Dependent On Fibronectin and Enhanced By Integrins α11β1and α2β1 * , 2002, The Journal of Biological Chemistry.

[97]  D. Hocking,et al.  Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions. , 2002, Molecular biology of the cell.

[98]  Ľ.,et al.  Changes in the Bone Tissue Lipids in Persons with Steroid- and Alcohol-induced Osteonecrosis , 2002 .

[99]  R Müller,et al.  Effects of Daily Treatment with Parathyroid Hormone on Bone Microarchitecture and Turnover in Patients with Osteoporosis: A Paired Biopsy Study * , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[100]  P. Fratzl,et al.  Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women. , 2001, Bone.

[101]  M. Morris,et al.  Application of vibrational spectroscopy to the study of mineralized tissues (review). , 2000, Journal of biomedical optics.

[102]  M. Emi,et al.  Association of bone mineral density with polymorphism of the human matrix Gla protein locus in elderly women , 2000, Journal of Bone and Mineral Metabolism.

[103]  A. Boskey,et al.  Intermittent and Continuous Administration of the Bisphosphonate Ibandronate in Ovariohysterectomized Beagle Dogs: Effects on Bone Morphometry and Mineral Properties , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[104]  S. Goldstein,et al.  Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice , 1998, Nature Genetics.

[105]  A. Boskey,et al.  Calcitonin Alters Bone Quality in Beagle Dogs , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[106]  P. Robey,et al.  Extracellular matrix stoichiometry in osteoblasts from patients with osteogenesis imperfecta , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[107]  M. Grynpas,et al.  The distribution of soluble, mineral-bound, and matrix-bound proteins in osteoporotic and normal bones. , 1994, Bone.

[108]  D. Eyre,et al.  Collagen crosslinks and mineral crystallinity in bone of patients with osteogenesis imperfecta , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[109]  J. Kopp,et al.  Osteogenesis imperfecta: Changes in noncollagenous proteins in bone , 1991, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[110]  P. Bullough,et al.  Changes in the bone tissue lipids in persons with steroid- and alcohol-induced osteonecrosis. , 1983, Clinical orthopaedics and related research.