Efficient One-Pot Synthesis of Tetrahydrobenzo[b]pyrans by Ethylenediamine Diacetate-Catalyzed Multicomponent Reaction Under Solvent-Free Conditions

ABSTRACT Ethylenediamine diacetate is found to be an efficient catalyst for the multicomponent condensation reaction of dimedone, aldehydes, and malononitrile to afford the corresponding tetrahydrobenzo[b]pyrans in good yields. The remarkable features of this new procedure are high yields, short reaction times, simple experimental and work-up procedures, mild and environmentally friendly reaction conditions, and economic availability of the catalyst.

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