Event-related potentials associated with covert orientation of visual attention in Parkinson's disease

Event-related potentials (ERPs) were measured in a group of patients with idiopathic Parkinson's disease and compared with a matched control group during a task involving covert orientation of visual attention. Central warning cues directed attention to the probable location of a lateralized signal that required a button-press response. Parkinson patients had enhanced post-cue P1 (at Oz) and P2 (at Cz) amplitudes, delayed N1 (at Oz) latencies, and diminished CNV amplitudes. Post-target amplitudes were similar to controls, except for an enhanced P1 to invalidly cued targets, and delayed N1 and P3 target latencies. These results indicate that Parkinson patients, in addition to their motor deficits, process spatial cues more effortfully and slowly, have impaired response preparation, and process imperative stimuli more slowly.

[1]  S A Hillyard,et al.  Sensory gating as a physiological mechanism for visual selective attention. , 1987, Electroencephalography and clinical neurophysiology. Supplement.

[2]  G. Geffen,et al.  Covert orientation of visual attention in Parkinson's disease: An impairment in the maintenance of attention , 1990, Neuropsychologia.

[3]  K. Hirayama,et al.  Covert orienting attention in Parkinson's disease. , 1990, Journal of neurology, neurosurgery, and psychiatry.

[4]  F. J. Friedrich,et al.  COGNITION AND THE BASAL GANGLIA , 1984 .

[5]  M. R. Harter,et al.  Visual-spatial attention: preparation and selection in children and adults. , 1991, Electroencephalography and clinical neurophysiology. Supplement.

[6]  M. Kupersmith,et al.  Visual system abnormalities in patients with Parkinson's disease. , 1982, Archives of neurology.

[7]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[8]  M. Posner,et al.  Localization of cognitive operations in the human brain. , 1988, Science.

[9]  Second Edition,et al.  Statistical Package for the Social Sciences , 1970 .

[10]  T W Picton,et al.  The effects of age on human event-related potentials. , 1984, Psychophysiology.

[11]  John W. Rohrbaugh,et al.  13 Sensory and Motor Aspects of the Contingent Negative Variation , 1983 .

[12]  S. Vanchilingam,et al.  Effect of L‐dopa on visual evoked potential in patients with Parkinson's disease , 1986, Neurology.

[13]  M. Annett.  A classification of hand preference by association analysis. , 1970, British journal of psychology.

[14]  M. Yahr,et al.  Measurements of visual evoked potentials in Parkinson's disease. , 1978, Brain : a journal of neurology.

[15]  M. Ghilardi,et al.  Visual evoked potentials in parkinsonism and dopamine blockade reveal a stimulus-dependent dopamine function in humans. , 1986, Journal of neurology, neurosurgery, and psychiatry.

[16]  N. Squires,et al.  Evoked potential changes and neuropsychological performance in Parkinson's disease , 1987, Biological Psychology.

[17]  J. Rohrbaugh,et al.  ERPs associated with preparatory and movement-related processes. A review. , 1986, Electroencephalography and clinical neurophysiology. Supplement.

[18]  M. Hoehn,et al.  Parkinsonism , 1967, Neurology.

[19]  Klaus P. Ebmeier,et al.  Event related potentials, reaction time, and cognitive performance in idiopathic Parkinson's disease , 1992, Biological Psychology.

[20]  S. Hillyard,et al.  Modulations of sensory-evoked brain potentials indicate changes in perceptual processing during visual-spatial priming. , 1991, Journal of experimental psychology. Human perception and performance.

[21]  G. Geffen,et al.  Catecholamines and the covert orientation of attention in humans , 1989, Neuropsychologia.

[22]  P. Holcomb,et al.  The effects of aging on the P3 component of the visual event-related potential. , 1985, Electroencephalography and clinical neurophysiology.

[23]  Samuel D. Conte,et al.  Elementary Numerical Analysis: An Algorithmic Approach , 1975 .

[24]  G. Mulder,et al.  Event-Related Brain Research (EEG suppl. 42) , 1991 .

[25]  R. Leiguarda,et al.  Evoked potentials, reaction time and cognitive performance in on and off phases of Parkinson's disease. , 1989, Journal of neurology, neurosurgery, and psychiatry.

[26]  S. Hillyard,et al.  Visual evoked potentials and selective attention to points in space , 1977 .

[27]  E. Donchin,et al.  On the dependence of P300 latency on stimulus evaluation processes. , 1984, Psychophysiology.

[28]  M. Yahr,et al.  Dopaminergic deficiency and delayed visual evoked potentials in humans , 1982, Annals of neurology.

[29]  D. Regan.  Human brain electrophysiology: Evoked potentials and evoked magnetic fields in science and medicine , 1989 .

[30]  The Bereitschaftspotential in preparation to mental activities. , 1988, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[31]  M. R. Harter,et al.  Hemispheric differences in the neural processing of stimulus location and type: Effects of selective attention on visual evoked potentials , 1982, Neuropsychologia.

[32]  R. Eason.  Visual evoked potential correlates of early neural filtering during selective attention , 1981 .

[33]  Steven L. Miller,et al.  Neural Processes Involved in Directing Attention , 1989, Journal of Cognitive Neuroscience.

[34]  J. Tecce.  Contingent negative variation (CNV) and psychological processes in man. , 1972, Psychological bulletin.

[35]  J C Rothwell,et al.  The Bereitschaftspotential is abnormal in Parkinson's disease. , 1989, Brain : a journal of neurology.

[36]  D. Wastell,et al.  Evoked potential correlates of visual selective attention. , 1980, Acta psychologica.

[37]  F. Karayanidis.  Parkinson's disease: A conceptualization of neuropsychological deficits within an information-processing framework , 1989, Biological Psychology.

[38]  S A Hillyard,et al.  The spatial orienting of attention: sensory facilitation or response bias? , 1987, Electroencephalography and clinical neurophysiology. Supplement.

[39]  J. Simpson,et al.  Readiness potential of cortical area 6 preceding self paced movement in Parkinson's disease. , 1987, Journal of neurology, neurosurgery, and psychiatry.

[40]  W. Zung.  A SELF-RATING DEPRESSION SCALE. , 1965, Archives of general psychiatry.

[41]  A Pfefferbaum,et al.  Clinical application of the P3 component of event-related potentials. I. Normal aging. , 1984, Electroencephalography and clinical neurophysiology.