Outcome after Complicated Minor Head Injury

BACKGROUND AND PURPOSE: Functional outcome in patients with minor head injury with neurocranial traumatic findings on CT is largely unknown. We hypothesized that certain CT findings may be predictive of poor functional outcome. Materials and METHODS: All patients from the CT in Head Injury Patients (CHIP) study with neurocranial traumatic CT findings were included. The CHIP study is a prospective, multicenter study of consecutive patients, ≥16 years of age, presenting within 24 hours of blunt head injury, with a Glasgow Coma Scale (GCS) score of 13–14 or a GCS score of 15 and a risk factor. Primary outcome was functional outcome according to the Glasgow Outcome Scale (GOS). Other outcome measures were the modified Rankin Scale (mRS), the Barthel Index (BI), and number and severity of postconcussive symptoms. The association between CT findings and outcome was assessed by using univariable and multivariable regression analysis. RESULTS: GOS was assessed in 237/312 patients (76%) at an average of 15 months after injury. There was full recovery in 150 patients (63%), moderate disability in 70 (30%), severe disability in 7 (3.0%), and death in 10 (4.2%). Outcome according to the mRS and BI was also favorable in most patients, but 82% of patients had postconcussive symptoms. Evidence of parenchymal damage was the only independent predictor of poor functional outcome (odds ratio = 1.89, P = .022). CONCLUSION: Patients with neurocranial complications after minor head injury generally make a good functional recovery, but postconcussive symptoms may persist. Evidence of parenchymal damage on CT was predictive of poor functional outcome.

[1]  Foss Mv MANAGEMENT OF VIRUS HEPATITIS. , 1964 .

[2]  F. Mahoney,et al.  FUNCTIONAL EVALUATION: THE BARTHEL INDEX. , 2018, Maryland state medical journal.

[3]  S. Attar,et al.  Mitral valve replacement. , 1965, Maryland state medical journal.

[4]  B Jennett,et al.  Assessment of outcome after severe brain damage. , 1975, Lancet.

[5]  B. Jennett,et al.  ASSESSMENT OF OUTCOME AFTER SEVERE BRAIN DAMAGE A Practical Scale , 1975, The Lancet.

[6]  B. Giordani,et al.  Disability caused by minor head injury. , 1981, Neurosurgery.

[7]  H. Schouten,et al.  Interobserver agreement for the assessment of handicap in stroke patients. , 1988, Stroke.

[8]  R. Bloch,et al.  Interobserver agreement for the assessment of handicap in stroke patients. , 1988, Stroke.

[9]  Douglas G. Altman,et al.  Practical statistics for medical research , 1990 .

[10]  Harvey S. Levin,et al.  Mild head injury classification. , 1990, Neurosurgery.

[11]  J. Vandenbroucke Prospective or retrospective: what's in a name? , 1991, BMJ.

[12]  N. Bohnen,et al.  Neurobehavioral Aspects of Postconcussive Symptoms after Mild Head Injury , 1992, The Journal of nervous and mental disease.

[13]  R. Evans The postconcussion syndrome and the sequelae of mild head injury. , 1992, Neurologic clinics.

[14]  M. Fearnside,et al.  The Westmead Head Injury Project outcome in severe head injury. A comparative analysis of pre-hospital, clinical and CT variables. , 1993, British journal of neurosurgery.

[15]  Y. Tu,et al.  Changes of brainstem and perimesencephalic cistern: dynamic predictor of outcome in severe head injury. , 1995, The Journal of trauma.

[16]  L R Salmi,et al.  Prevalence of impairments 5 years after a head injury, and their relationship with disabilities and outcome. , 1996, Brain injury.

[17]  R. Derlet,et al.  Utilizing clinical factors to reduce head CT scan ordering for minor head trauma patients. , 1997, The Journal of emergency medicine.

[18]  G. Teasdale,et al.  Structured interviews for the Glasgow Outcome Scale and the extended Glasgow Outcome Scale: guidelines for their use. , 1998, Journal of neurotrauma.

[19]  K. Waterloo,et al.  Quantification of post-concussion symptoms 3 months after minor head injury in 100 consecutive patients , 1998, Journal of Neurology.

[20]  B Jennett,et al.  Analyzing outcome of treatment of severe head injury: a review and update on advancing the use of the Glasgow Outcome Scale. , 1998, Journal of neurotrauma.

[21]  A. V. Zomeren,et al.  One year outcome in mild to moderate head injury: the predictive value of acute injury characteristics related to complaints and return to work , 1999, Journal of neurology, neurosurgery, and psychiatry.

[22]  M. Dombovy,et al.  Epidemiology and predictors of post-concussive syndrome after minor head injury in an emergency population. , 1999, Brain injury.

[23]  G. Murray,et al.  Disability in young people and adults one year after head injury: prospective cohort study , 2000, BMJ : British Medical Journal.

[24]  Reston,et al.  INDICATIONS FOR COMPUTED TOMOGRAPHY IN PATIENTS WITH MINOR HEAD INJURY , 2000 .

[25]  Wendell A. Gibby,et al.  Neuroimaging : clinical and physical principles , 2000 .

[26]  G. Teasdale,et al.  Emotional and cognitive consequences of head injury in relation to the Glasgow outcome scale , 2000, Journal of neurology, neurosurgery, and psychiatry.

[27]  T. McDaniel Head and Brain Trauma , 2000 .

[28]  J. Wilson Assessing outcome in head injury trials. , 2001, Current pharmaceutical design.

[29]  J. Claar,et al.  Imaging of acute head injury in the adult. , 2001, Seminars in ultrasound, CT, and MR.

[30]  George A Wells,et al.  The Canadian CT Head Rule for patients with minor head injury , 2001, The Lancet.

[31]  J. van der Naalt Prediction of outcome in mild to moderate head injury: a review. , 2001, Journal of clinical and experimental neuropsychology.

[32]  Wilson Jt Assessing outcome in head injury trials. , 2001 .

[33]  Kyle A Krehbiel Neuroimaging: Clinical and Physical Principles , 2001, Modern Pathology.

[34]  J. Wardlaw,et al.  Which CT features help predict outcome after head injury? , 2002, Journal of neurology, neurosurgery, and psychiatry.

[35]  E. Weitzberg,et al.  Outcome of traumatic brain injuries in 1,508 patients: impact of prehospital care. , 2002, Journal of neurotrauma.

[36]  L. Battistin,et al.  EFNS guideline on mild traumatic brain injury: report of an EFNS task force , 2002, European journal of neurology.

[37]  S. Dikmen,et al.  Correlates of functional status 3-5 years after traumatic brain injury with CT abnormalities. , 2003, Journal of neurotrauma.

[38]  G. Raque,et al.  Outcome following moderate traumatic brain injury. , 2003, Surgical neurology.

[39]  M. Britton,et al.  Mild head injury – mortality and complication rate: meta-analysis of findings in a systematic literature review , 2003, Acta Neurochirurgica.

[40]  C. Atzema,et al.  Defining "therapeutically inconsequential" head computed tomographic findings in patients with blunt head trauma. , 2004, Annals of emergency medicine.

[41]  V. Coronado,et al.  Methodological issues and research recommendations for mild traumatic brain injury: the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury. , 2004, Journal of rehabilitation medicine.

[42]  D. Wade,et al.  The Rivermead Post Concussion Symptoms Questionnaire: a measure of symptoms commonly experienced after head injury and its reliability , 1995, Journal of Neurology.

[43]  G. Marchesini,et al.  Prospective validation of a proposal for diagnosis and management of patients attending the emergency department for mild head injury , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[44]  Hans von Holst,et al.  Diagnostic procedures in mild traumatic brain injury: results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury. , 2004, Journal of rehabilitation medicine.

[45]  J. Borg,et al.  Prognosis for mild traumatic brain injury: results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury. , 2004, Journal of rehabilitation medicine.

[46]  G. Marchesini,et al.  Clinical performance of NICE recommendations versus NCWFNS proposal in patients with mild head injury. , 2005, Journal of neurotrauma.

[47]  D. Marion,et al.  Early Glasgow Outcome Scale scores predict long-term functional outcome in patients with severe traumatic brain injury. , 2005, Journal of neurotrauma.

[48]  Barbara Gregson,et al.  Design and analysis of phase III trials with ordered outcome scales: the concept of the sliding dichotomy. , 2005, Journal of neurotrauma.

[49]  Marion Smits,et al.  External validation of the Canadian CT Head Rule and the New Orleans Criteria for CT scanning in patients with minor head injury. , 2005, JAMA.

[50]  J. Hsiang High-risk mild head injury. , 2005, Journal of long-term effects of medical implants.

[51]  M. Britton,et al.  Medical outcome after immediate computed tomography or admission for observation in patients with mild head injury: randomised controlled trial , 2006, BMJ : British Medical Journal.

[52]  M. Britton,et al.  Immediate computed tomography or admission for observation after mild head injury: cost comparison in randomised controlled trial , 2006, BMJ : British Medical Journal.

[53]  H. Marcovitch Managing minor head injury in children , 2006, BMJ : British Medical Journal.

[54]  E. Bor-Seng-Shu,et al.  The value of cranial computed tomography in high-risk, mildly head-injured patients. , 2006, Surgical neurology.