BACKGROUND: In developing countries, surgical site infections (SSIs) are imposing a heavy and potentially preventable burden on both patients and healthcare providers. The aim of this Study was to isolated & identify organisms from SSI and to study their antibiotic resistance pattern. METHODS AND MATERIALS: This Prospective study was conducted in the microbiology laboratory attached to a tertiary care Centre, over a period of 18 months (1st February 2012 to 31st July 2013). 100 cases were randomly included from culture positive post-operative wound infection cases. Standard microbiological techniques were used to isolate and identify the organisms and to study antibiotic resistance pattern. RESULTS: SSI rate was 6.97%, Staphylococcus aureus, E.coli, P. aeruginosa, Acinetobacter baumannii were the most commonly isolated organisms. All staphylococci were susceptible to Vancomycin and Teicoplanin. All Gram negative bacilli were 100% sensitive to Colistin and Polymyxin-B. CONCLUSION: The incidence of multidrug resistance pathogens as a cause of SSI is rising. Rapid and accurate detection of these pathogens and their antibiogram is important for prevention of morbidity and mortality associated with SS
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