A Real-Time QRS Detection System With PR/RT Interval and ST Segment Measurements for Wearable ECG Sensors Using Parallel Delta Modulators

This paper presents a real-time electrocardiogram (ECG) monitoring system for wearable devices. The system is based on the proposed parallel delta modulator architecture with local maximum point and local minimum point algorithms to detect QRS and PT waves. Therefore, using the proposed system and algorithm, real-time PR and RT intervals, and ST segment measurements can be achieved in long-term wearable ECG recording. The algorithm is tested with the MIT-BIH Arrhythmia Database for QRS complex detection and with the QT Database for the P and T wave detections. The simulation result shows that the algorithm achieves above 99%, 91%, and 98% accuracy in the QRS complex, P wave, and T wave detections, respectively. Experimental results are presented from the system prototype, in which the parallel delta modulator circuits are fabricated in IBM 0.13 <inline-formula><tex-math notation="LaTeX">$\mu \text{m}$</tex-math></inline-formula> standard CMOS technology and the algorithms are implemented in a Xilinx Spartan-6 field programmable gate array (FPGA). The parallel delta modulators consume 720 nW at 1 kHz sampling rate with <inline-formula><tex-math notation="LaTeX">$\pm$</tex-math></inline-formula>0.6 V power supply. The proposed system has the potential to be applied in future long-term wearable ECG recording devices.

[1]  Feng Wan,et al.  A 0.83-$\mu {\rm W}$ QRS Detection Processor Using Quadratic Spline Wavelet Transform for Wireless ECG Acquisition in 0.35- $\mu{\rm m}$ CMOS , 2012, IEEE Transactions on Biomedical Circuits and Systems.

[2]  Yong Lian,et al.  A 300-mV 220-nW Event-Driven ADC With Real-Time QRS Detection for Wearable ECG Sensors , 2014, IEEE Transactions on Biomedical Circuits and Systems.

[3]  Jeffrey J. Goldberger,et al.  The Association between the PR Interval and Left Ventricular Measurements in the Multiethnic Study of Atherosclerosis , 2015, Cardiology research and practice.

[4]  M.B. Shamsollahi,et al.  Model-based ECG fiducial points extraction using a modified extended Kalman filter structure , 2008, 2008 First International Symposium on Applied Sciences on Biomedical and Communication Technologies.

[5]  S. Sonkusale,et al.  Adaptive asynchronous analog to digital conversion for compressed biomedical sensing , 2009, 2009 IEEE Biomedical Circuits and Systems Conference.

[6]  Carlos V. Regueiro,et al.  Classifying multichannel ECG patterns with an adaptive neural network. , 1998, IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society.

[7]  François Charpillet,et al.  A Multi-HMM Approach to ECG Segmentation , 2006, 2006 18th IEEE International Conference on Tools with Artificial Intelligence (ICTAI'06).

[8]  José Silva-Martínez,et al.  The Recycling Folded Cascode: A General Enhancement of the Folded Cascode Amplifier , 2009, IEEE Journal of Solid-State Circuits.

[9]  Jordi Parramon,et al.  A Low-Power Configurable Neural Recording System for Epileptic Seizure Detection , 2013, IEEE Transactions on Biomedical Circuits and Systems.

[10]  Yong Lian,et al.  A 0.7-V 17.4-/spl mu/W 3-Lead Wireless ECG SoC , 2013, IEEE Transactions on Biomedical Circuits and Systems.

[11]  Pablo Laguna,et al.  A database for evaluation of algorithms for measurement of QT and other waveform intervals in the ECG , 1997, Computers in Cardiology 1997.

[12]  Jean-Yves Tourneret,et al.  P- and T-Wave Delineation in ECG Signals Using a Bayesian Approach and a Partially Collapsed Gibbs Sampler , 2010, IEEE Transactions on Biomedical Engineering.

[13]  H. Huikuri,et al.  Prognostic significance of prolonged PR interval in the general population. , 2014, European heart journal.

[14]  Pawel Strumillo,et al.  Nested median filtering for detecting T-wave offset in ECGs , 2002 .

[15]  José Carlos Príncipe,et al.  Integrate and Fire Pulse Train Automaton for QRS detection , 2014, IEEE Transactions on Biomedical Engineering.

[16]  G. Nollo,et al.  Beat-to-beat measurement and analysis of the R-T interval in 24 h ECG Holter recordings , 1993, Medical and Biological Engineering and Computing.

[17]  Yoshihiro Kokubo,et al.  Abstract 13451: Prolonged PR Interval is Significantly Associated with Increased Risk of Cardiovascular Diseases and Strokes in a Population-based Cohort Study , 2014 .

[18]  Zhe Zhang,et al.  A 2.89 $\mu $ W Dry-Electrode Enabled Clockless Wireless ECG SoC for Wearable Applications , 2016, IEEE Journal of Solid-State Circuits.

[19]  Andreas Holzinger,et al.  Online and Offline Determination of QT and PR Interval and QRS Duration in Electrocardiography , 2012, ICPCA/SWS.

[20]  H. Mabuchi,et al.  T wave peak-to-end interval and QT dispersion in acquired long QT syndrome: a new index for arrhythmogenicity. , 2003, Clinical science.

[21]  P Caminal,et al.  Automatic detection of wave boundaries in multilead ECG signals: validation with the CSE database. , 1994, Computers and biomedical research, an international journal.

[22]  Jeffrey M. Hausdorff,et al.  Physionet: Components of a New Research Resource for Complex Physiologic Signals". Circu-lation Vol , 2000 .

[23]  Bozena Kaminska,et al.  Mechanically Flexible Wireless Multisensor Platform for Human Physical Activity and Vitals Monitoring , 2010, IEEE Transactions on Biomedical Circuits and Systems.

[24]  Rui Paulo Martins,et al.  A 0.83-µW QRS Detection Processor Using Quadratic Spline Wavelet Transform for Wireless ECG Acquisition in 0.35-µm CMOS , 2012, IEEE Trans. Biomed. Circuits Syst..

[25]  Hamidreza Rezaee-Dehsorkh,et al.  An event-based ECG-monitoring and QRS-detection system based on level-crossing sampling , 2017, 2017 Iranian Conference on Electrical Engineering (ICEE).

[26]  Sameer R. Sonkusale,et al.  Input-Feature Correlated Asynchronous Analog to Information Converter for ECG Monitoring , 2011, IEEE Transactions on Biomedical Circuits and Systems.

[27]  H V PIPBERGER,et al.  The P Wave, P‐R Interval, and Q‐T Ratio of the Normal Orthogonal Electrocardiogram , 1958, Circulation.

[28]  Hiroshi Morita,et al.  The QT syndromes: long and short , 2008, The Lancet.

[29]  Charles Sodini,et al.  A 58 nW ECG ASIC With Motion-Tolerant Heartbeat Timing Extraction for Wearable Cardiovascular Monitoring , 2015, IEEE Transactions on Biomedical Circuits and Systems.

[30]  G. Baselli,et al.  Performance assessment of standard algorithms for dynamic R-T interval measurement: comparison between R-Tapex and R-Tend approach , 2006, Medical and Biological Engineering and Computing.

[31]  Yi-Gyeong Kim,et al.  A 0.9-V 60-$\mu{\hbox {W}}$ 1-Bit Fourth-Order Delta-Sigma Modulator With 83-dB Dynamic Range , 2008, IEEE Journal of Solid-State Circuits.

[32]  Jens Seiler,et al.  Is 7-day event triggered ECG recording equivalent to 7-day Holter ECG recording for atrial fibrillation screening? , 2012, Heart.

[33]  T. Chevalier,et al.  The ECG in pulmonary embolism. Predictive value of negative T waves in precordial leads--80 case reports. , 1997, Chest.

[34]  Senén Barro,et al.  A new approach for TU complex characterization , 2000, IEEE Transactions on Biomedical Engineering.

[35]  B. McCrindle,et al.  Long-term outcome and prognostic determinants in children with hypertrophic cardiomyopathy. , 1998, Journal of the American College of Cardiology.

[36]  David Atienza,et al.  Development and Evaluation of Multilead Wavelet-Based ECG Delineation Algorithms for Embedded Wireless Sensor Nodes , 2011, IEEE Transactions on Information Technology in Biomedicine.

[37]  M. Gold,et al.  Long-term Outcomes in Individuals With Prolonged PR Interval or First-Degree Atrioventricular Block , 2010 .

[38]  G. Boudreaux-Bartels,et al.  Wavelet transform-based QRS complex detector , 1999, IEEE Transactions on Biomedical Engineering.

[39]  G.B. Moody,et al.  The impact of the MIT-BIH Arrhythmia Database , 2001, IEEE Engineering in Medicine and Biology Magazine.

[40]  M. Fornage,et al.  Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association , 2017, Circulation.

[41]  C. Van Hoof,et al.  Motion artifact removal using cascade adaptive filtering for ambulatory ECG monitoring system , 2012, 2012 IEEE Biomedical Circuits and Systems Conference (BioCAS).

[42]  Phan Chee Hou,et al.  An embedded delta modulator system for coding speech signals , 2014, 2014 2nd International Conference on Electronic Design (ICED).

[43]  Yi-Gyeong Kim,et al.  A 0.6-V Delta–Sigma Modulator With Subthreshold-Leakage Suppression Switches , 2009, IEEE Transactions on Circuits and Systems II: Express Briefs.

[44]  Tor Sverre Lande,et al.  Power-Efficient Cross-Correlation Beat Detection in Electrocardiogram Analysis Using Bitstreams , 2010, IEEE Transactions on Biomedical Circuits and Systems.

[45]  A. Krahn,et al.  Hysteresis of the RT interval with exercise: a new marker for the long-QT syndrome? , 1997, Circulation.

[46]  Zafer Cömert,et al.  Determination of QT interval on synthetic electrocardiogram , 2015, 2015 23nd Signal Processing and Communications Applications Conference (SIU).

[47]  Pablo Laguna,et al.  A wavelet-based ECG delineator: evaluation on standard databases , 2004, IEEE Transactions on Biomedical Engineering.