Severe anaphylactoid reaction to nalidixic acid

We present the case of a 58‐year‐old non‐atopic woman who suffered an adverse reaction to orally administered nalidixic acid, which had been prescribed for the treatment of a urinary tract infection. The single‐blind oral provocation test was positive; the patient presented the clinical features of an anaphylactoid reaction 3 min after administration of nalidixic acid. Both the skin test and the histamine release test were negative. These results suggest that we are dealing with an anaphylactoid reaction not described before with this drug.

[1]  R. Meyboom.  Thrombocytopenia induced by nalidixic acid. , 1984, British medical journal.

[2]  J. Tuomisto,et al.  Miscellaneous antibacterial and antiviral drugs , 1984 .

[3]  G. Landini,et al.  Fatal acute immune haemolytic anaemia caused by nalidixic acid. , 1982, British medical journal.

[4]  P. Zech,et al.  Nalidixic acid kinetics after single and repeated oral doses , 1981, Clinical pharmacology and therapeutics.

[5]  A. Boisvert,et al.  Nalidixic Acid-Induced Photodermatitis after Minimal Sun Exposure , 1981, Drug intelligence & clinical pharmacy.

[6]  A. Rubinstein.  LE-like disease caused by nalidixic acid. , 1979, The New England journal of medicine.

[7]  S. Haberman,et al.  New classification of stroke: preliminary communication. , 1977, British medical journal.

[8]  A. Fraser,et al.  Convulsions and hyperglycaemia associated with nalidixic acid. , 1977, British medical journal.

[9]  R. R. Bailey,et al.  Nalidixic acid arthralgia. , 1972, Canadian Medical Association journal.

[10]  T. Stamey.  Observations on the clinical use of nalidixic acid. , 1971, Postgraduate medical journal.

[11]  R. Petersdorf,et al.  A critical evaluation of nalidixic acid in urinary-tract infections. , 1966, The New England journal of medicine.

[12]  E. McChesney,et al.  BIOPHARMACEUTICAL INVESTIGATION OF NALIDIXIC ACID IN MAN. , 1965, Journal of pharmaceutical sciences.

[13]  D. Rosi,et al.  ABSORPTION, EXCRETION, AND METABOLISM OF A NEW ANTIBACTERIAL AGENT, NALIDIXIC ACID. , 1964, Toxicology and applied pharmacology.