Evaluation of Chest Motion and Volumetry During the Breathing Cycle by Dynamic MRI in Healthy Subjects: Comparison With Pulmonary Function Tests

Rationale and Objectives:To investigate diaphragm and chest wall motion during the whole breathing cycle using magnetic resonance imaging (MRI) and a volumetric model in correlation with spirometry. Materials and Methods:Breathing cycles of 15 healthy volunteers were examined using a trueFISP sequence (5 slices in 3 planes, 3 images per second). Time–distance curves were calculated and correlated to spirometry. A model for vital capacity (VC), continuous time-dependent vital capacity (tVC), and investigating the influence of horizontal and vertical parameters on tVC was introduced. Results:Time–distance curves of the breathing cycle using MRI correlated highly significant with spirometry (P < 0.0001). VC calculated by the model was similar to VC measured in spirometry (5.00 L vs. 5.15 L). tVC correlated highly significantly with spirometry (P < 0.0001). Vertical parameters had a more profound influence on tVC change than horizontal parameters. Conclusions:Dynamic MRI is a simple noninvasive method to evaluate local chest wall motion and respiratory mechanics. It widens the repertoire of tools for lung examination with a high temporal resolution.

[1]  K. Esato,et al.  Impaired respiratory mechanics in pulmonary emphysema: Evaluation with dynamic breathing MRI , 1999, Journal of magnetic resonance imaging : JMRI.

[2]  H. Kauczor,et al.  Volumetry of Ventilated Airspaces by 3He MRI: Preliminary Results , 2001, Investigative radiology.

[3]  J Clausen,et al.  Measurement of absolute lung volumes by imaging techniques. , 1997, The European respiratory journal.

[4]  N. Raichura,et al.  Breath-hold MRI in evaluating patients with pectus excavatum. , 2001, The British journal of radiology.

[5]  S. Erickson,et al.  Diaphragmatic motion: fast gradient-recalled-echo MR imaging in healthy subjects. , 1995, Radiology.

[6]  Gerald M. Saidel,et al.  Mathematical model of chest wall mechanics: A phenomenological approach , 2006, Annals of Biomedical Engineering.

[7]  D M Shames,et al.  Radiographically determined lung volumes at full inspiration and during dynamic forced expiration in normal subjects. , 1975, Investigative radiology.

[8]  W A Whitelaw,et al.  Shape and size of the human diaphragm in vivo. , 1987, Journal of applied physiology.

[9]  T Kondo,et al.  A dynamic analysis of chest wall motions with MRI in healthy young subjects * , 2000, Respirology.

[10]  M Paiva,et al.  Mechanical implications of in vivo human diaphragm shape. , 1992, Journal of applied physiology.

[11]  John F. Nunn,et al.  Nunn's Applied Respiratory Physiology , 1993 .

[12]  V. Napadow,et al.  Determination of regional pulmonary parenchymal strain during normal respiration using spin inversion tagged magnetization MRI , 2001, Journal of magnetic resonance imaging : JMRI.

[13]  R M Slone,et al.  MR analysis of lung volume and thoracic dimensions in patients with emphysema before and after lung volume reduction surgery. , 1998, AJR. American journal of roentgenology.

[14]  J C Rosenwald,et al.  Conformal radiotherapy (CRT) planning for lung cancer: analysis of intrathoracic organ motion during extreme phases of breathing. , 2001, International journal of radiation oncology, biology, physics.

[15]  A. B. Dubois,et al.  Radiographic and plethysmographic determination of total lung capacity. , 1966, Radiology.

[16]  Jürgen Debus,et al.  The Use of the Multislice CT for the Determination of Respiratory Lung Tumor Movement in Stereotactic Single-Dose Irradiation , 2003, Strahlentherapie und Onkologie.

[17]  F. Schick,et al.  [Imaging diagnosis of solitary pulmonary nodules on an open low-field MRI system--comparison of two MR sequences with spiral CT]. , 2002, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[18]  M Thelen,et al.  Assessment of lung volumes using helical CT at inspiration and expiration: comparison with pulmonary function tests. , 1998, AJR. American journal of roentgenology.

[19]  P. Grenier,et al.  Diaphragm and chest wall: assessment of the inspiratory pump with MR imaging-preliminary observations. , 2000, Radiology.

[20]  F P Primiano,et al.  Theoretical analysis of chest wall mechanics. , 1982, Journal of biomechanics.

[21]  M. Schmitt,et al.  Dynamic contrast‐enhanced myocardial perfusion imaging using saturation‐prepared TrueFISP , 2002, Journal of magnetic resonance imaging : JMRI.

[22]  M. Polkey,et al.  Diaphragm strength in chronic obstructive pulmonary disease. , 1996, American journal of respiratory and critical care medicine.

[23]  J E Cotes,et al.  Lung volumes and forced ventilatory flows , 1993, European Respiratory Journal.

[24]  J C Leong,et al.  Kinematics of the chest cage and spine during breathing in healthy individuals and in patients with adolescent idiopathic scoliosis. , 1999, Spine.

[25]  D. Lynch,et al.  Pediatric pulmonary disease: assessment with high-resolution ultrafast CT. , 1990, Radiology.

[26]  M Paiva,et al.  Three-dimensional reconstruction of the in vivo human diaphragm shape at different lung volumes. , 1994, Journal of applied physiology.

[27]  H. Hatabu,et al.  Fast magnetic resonance imaging of the lung. , 1999, European journal of radiology.

[28]  K. Scheffler,et al.  Single‐breathhold 3D‐trueFISP cine cardiac imaging , 2002, Magnetic resonance in medicine.

[29]  Gerhard Laub,et al.  TrueFISP--technical considerations and cardiovascular applications. , 2003, European journal of radiology.

[30]  J. Mead,et al.  Mechanical interaction between the diaphragm and rib cage. , 1973, Journal of applied physiology.

[31]  A. Howseman,et al.  Estimation of lung volume in infants by echo planar imaging and total body plethysmography. , 1990, Archives of disease in childhood.

[32]  S. String,et al.  Radiographie and Plethysmographie Determination of Total Lung Capacity1 , 1966 .

[33]  Andrei Constantinescu,et al.  Mechanical model of the inspiratory pump. , 2002, Journal of biomechanics.

[34]  H. Kauczor,et al.  MRI of the pulmonary parenchyma , 1999, European Radiology.

[35]  勝之 宮坂,et al.  Chest wall mechanics の新展望 , 1990 .