RESEARCH REPORT ON EXPERIMENTAL AND CLINICAL SINUSITIS

SYNOPSIS OF EXPERIMENTS During 1934 and 1935 we continued our previous study (1930 to 1934) of the effects of surface applications to the normal and to the inflamed membranes of the frontal sinus of cats in which acute or chronic inflammatory changes closely resembling processes in man had been produced by inoculation with human strains of hemolytic streptococci. The technic and subsequent preparation of tissues was the same as that heretofore employed. Study of the absorption of particulate matter into the membranes of the sinuses was carried on by chipping away the bony roof of the sinus and placing 5 per cent prussian blue in 4 per cent gelatin in some animals and in others full strength india ink outside the intact normal membrane. It was noted that numerous histiocytes were attracted to the region exposed to the ink and prussian blue; these remained crowded together for twenty-four hours,