Inhibition of P-glycoprotein-mediated efflux by thiolated cyclodextrins.
暂无分享,去创建一个
A. Bernkop‐Schnürch | Flavia Laffleur | Eva Sanchez Armengol | Florina Veider | Soheil Haddadzadegan | G. Kali
[1] Rawiwan Maniratanachote,et al. Quaternization of high molecular weight chitosan for increasing intestinal drug absorption using Caco-2 cells as an in vitro intestinal model , 2023, Scientific reports.
[2] A. Bernkop‐Schnürch,et al. Thiolated α-cyclodextrin: The likely smallest drug carrier providing enhanced cellular uptake and endosomal escape. , 2023, Carbohydrate polymers.
[3] A. Silva,et al. Natural Products as a Tool to Modulate the Activity and Expression of Multidrug Resistance Proteins of Intestinal Barrier , 2023, Journal of xenobiotics.
[4] A. Bernkop‐Schnürch,et al. Thiolated cyclodextrins: A comparative study of their mucoadhesive properties. , 2023, International journal of pharmaceutics.
[5] G. Yahya,et al. Pharmaceutical polymers and P-glycoprotein: Current Trends and Possible Outcomes in Drug Delivery , 2023, Materials Today Communications.
[6] A. Bernkop‐Schnürch,et al. Per-thiolated cyclodextrins: Nanosized drug carriers providing a prolonged gastrointestinal residence time. , 2022, Carbohydrate polymers.
[7] S. Thayumanavan,et al. Thiol-Disulfide Exchange as a Route for Endosomal Escape of Polymeric Nanoparticles. , 2022, Angewandte Chemie.
[8] M. Kao,et al. Novel application of rhein and its prodrug diacerein for reversing cancer-related multidrug resistance through the dual inhibition of P-glycoprotein efflux and STAT3-mediated P-glycoprotein expression. , 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[9] Xiaoqing Miao,et al. Strategies and Mechanism in Reversing Intestinal Drug Efflux in Oral Drug Delivery , 2022, Pharmaceutics.
[10] A. Piras,et al. Thiolated Hydroxypropyl-β-cyclodextrin: A Potential Multifunctional Excipient for Ocular Drug Delivery , 2022, International journal of molecular sciences.
[11] Mei Wang,et al. Comparison of the permeability between conjugated estrogens and atenolol in rat in situ single-pass intestinal perfusions model and in Caco-2 cell monolayers , 2022, Journal of Drug Delivery Science and Technology.
[12] K. Giacomini,et al. Interaction of Commonly Used Oral Molecular Excipients with P-glycoprotein , 2021, The AAPS Journal.
[13] C. Hrycyna,et al. The roles of the human ATP-binding cassette transporters P-glycoprotein and ABCG2 in multidrug resistance in cancer and at endogenous sites: future opportunities for structure-based drug design of inhibitors , 2021, Cancer drug resistance.
[14] A. Bernkop‐Schnürch,et al. Thiolated pectins: In vitro and ex vivo evaluation of three generations of thiomers. , 2021, Acta biomaterialia.
[15] A. Bernkop‐Schnürch,et al. Thiolated cyclodextrins: Mucoadhesive and permeation enhancing excipients for ocular drug delivery. , 2021, International journal of pharmaceutics.
[16] A. Bernkop‐Schnürch,et al. Thiolated cyclodextrins: New perspectives for old excipients , 2020, Coordination Chemistry Reviews.
[17] A. Bernkop‐Schnürch,et al. Per-6-Thiolated Cyclodextrins: A Novel Type of Permeation Enhancing Excipients for BCS Class IV Drugs , 2020, ACS applied materials & interfaces.
[18] Liping Wang,et al. Nanostructured lipid carriers with exceptional gastrointestinal stability and inhibition of P-gp efflux for improved oral delivery of tilmicosin. , 2019, Colloids and surfaces. B, Biointerfaces.
[19] B. Vaidya,et al. Nintedanib-cyclodextrin complex to improve bio-activity and intestinal permeability. , 2019, Carbohydrate polymers.
[20] L. Szente,et al. Complex Formation of Resorufin and Resazurin with Β-Cyclodextrins: Can Cyclodextrins Interfere with a Resazurin Cell Viability Assay? , 2018, Molecules.
[21] Qiang Zhang,et al. The P-glycoprotein inhibitory effect and related mechanisms of thiolated chitosan and its S-protected derivative , 2015 .
[22] R. Sikes,et al. Cell-based assays using calcein acetoxymethyl ester show variation in fluorescence with treatment conditions. , 2015, Journal of biological methods.
[23] A. Bernkop‐Schnürch,et al. Thiomers: Influence of molecular mass and thiol group content of poly(acrylic acid) on efflux pump inhibition. , 2015, International journal of pharmaceutics.
[24] C. Huck,et al. Synthesis and In Vitro Evaluation of Thiolated Carrageenan. , 2015, Journal of pharmaceutical sciences.
[25] H. Valizadeh,et al. Intestinal transporters: enhanced absorption through P-glycoprotein-related drug interactions , 2014, Expert opinion on drug metabolism & toxicology.
[26] N. Cioffi,et al. Mucoadhesive properties and interaction with P-glycoprotein (P-gp) of thiolated-chitosans and -glycol chitosans and corresponding parent polymers: a comparative study. , 2014, Biomacromolecules.
[27] A. Yu,et al. ABC transporters in multidrug resistance and pharmacokinetics, and strategies for drug development. , 2014, Current pharmaceutical design.
[28] Ye Zhang,et al. Effects of β-cyclodextrin on the intestinal absorption of berberine hydrochloride, a P-glycoprotein substrate. , 2013, International journal of biological macromolecules.
[29] P. Nagy. Kinetics and mechanisms of thiol-disulfide exchange covering direct substitution and thiol oxidation-mediated pathways. , 2013, Antioxidants & redox signaling.
[30] Md. Lutful Amin. P-glycoprotein Inhibition for Optimal Drug Delivery , 2013, Drug target insights.
[31] A. Bernkop‐Schnürch,et al. S-protected thiolated chitosan for oral delivery of hydrophilic macromolecules: evaluation of permeation enhancing and efflux pump inhibitory properties. , 2012, Molecular pharmaceutics.
[32] J. Iqbal,et al. Thiolated chitosans: influence of various sulfhydryl ligands on permeation-enhancing and P-gp inhibitory properties , 2011, Drug development and industrial pharmacy.
[33] J. Iqbal,et al. Design and in vitro evaluation of a novel polymeric P-glycoprotein (P-gp) inhibitor. , 2010, Journal of controlled release : official journal of the Controlled Release Society.
[34] H. Takeuchi,et al. Modified chitosans for oral drug delivery. , 2009, Journal of pharmaceutical sciences.
[35] Gautam Mishra,et al. Effect of P-glycoprotein inhibitor, verapamil, on oral bioavailability and pharmacokinetics of irinotecan in rats. , 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[36] A. Bernkop‐Schnürch,et al. In vivo comparison of various polymeric and low molecular mass inhibitors of intestinal P-glycoprotein. , 2006, Biomaterials.
[37] A. Bernkop‐Schnürch,et al. In vivo evaluation of an oral delivery system for P-gp substrates based on thiolated chitosan. , 2006, Biomaterials.
[38] Martin Werle,et al. Glutathione and thiolated chitosan inhibit multidrug resistance P-glycoprotein activity in excised small intestine. , 2006, Journal of controlled release : official journal of the Controlled Release Society.
[39] J. Moore,et al. Use of Verapamil as a Potential P-Glycoprotein Inhibitor in a Patient with Refractory Epilepsy , 2004, The Annals of pharmacotherapy.
[40] W. Dalton,et al. Reversal of drug‐resistance in multiple myeloma with verapamil , 1988, British journal of haematology.
[41] Liefeng Zhang,et al. A cell-penetrating peptide conjugated carboxymethyl-β-cyclodextrin to improve intestinal absorption of insulin. , 2018, International journal of biological macromolecules.
[42] J. Iqbal,et al. Development and in vivo evaluation of an oral drug delivery system for paclitaxel. , 2011, Biomaterials.