Molecular Basis of Distant Medulloblastoma Recurrence

is also noteworthy that subgroup classification remains constant in recurrent tumors compared with primary tumors [3] , although there are significant genetic differences between primary tumors and recurrent tumors arising after therapy [4] . Understanding which MB subgroups are more likely to recur at distant and uncommon sites, and uncovering the biological identity of distant metastases, may help to identify the origin of these lesions and ultimately to develop more specific treatments focusing on the metastatic compartment.