Complexification of Gene Networks by Co-evolution of Genomes and Genomic Parasites

The co-evolution of species with their genomic parasites (transposons) is thought to be one of the primary ways of rewiring gene regulatory networks (GRNs). In this communication, we computationally explore some of the essential co-evolution aspects of hosts (GRNs) with their transposons. We implemented an evolutionary search of an appropriate GRN model design on the example of the Drosophila gap-gene network. Simple artificial transposons capable of spreading and transposition were implemented. With the model, we explored the hypothesis that targeting destruction of some of the regulatory connections in the GRN via the action of transposons can produce negative selection pressure. Functionally external genes can be recruited (co-opted) into the GRN under this selection pressure following transposon rewiring of the GRN. Over evolutionary time, transposition events are able to disrupt these new regulatory connections, leading to repeated cycles of recruitment, rewiring and optimization. This process can produce increasingly large GRNs with the same basic functions.

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