High stearoyl-CoA desaturase 1 expression is associated with shorter survival in breast cancer patients
暂无分享,去创建一个
Funda Meric-Bernstam | Kim-Anh Do | Lajos Pusztai | Gordon B. Mills | G. Mills | G. Hortobagyi | W. Fraser Symmans | L. Pusztai | K. Do | F. Meric-Bernstam | A. González-Angulo | A. Akcakanat | Huiqin Chen | Gabriel N. Hortobagyi | Huiqin Chen | Ana M. Gonzalez-Angulo | Ashley M. Holder | Argun Akcakanat | W. Fraser Symmans | A. Holder
[1] B. Yandell,et al. Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[2] H. Sham,et al. Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors. , 2008, Bioorganic & medicinal chemistry letters.
[3] F. Foufelle,et al. SREBP-1c Transcription Factor and Lipid Homeostasis: Clinical Perspective , 2007, Hormone Research in Paediatrics.
[4] J. Ntambi. Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol. , 1999, Journal of lipid research.
[5] M. Bonini,et al. Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK , 2009, PloS one.
[6] Brendan Connolly,et al. Development of a high-throughput screening assay for stearoyl-CoA desaturase using rat liver microsomes, deuterium labeled stearoyl-CoA and mass spectrometry. , 2008, Analytica chimica acta.
[7] B. Spiegelman,et al. Identification of Conserved cis-Elements and Transcription Factors Required for Sterol-regulated Transcription of Stearoyl-CoA Desaturase 1 and 2* , 1999, The Journal of Biological Chemistry.
[8] L. Zhang,et al. Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. , 1999, The Biochemical journal.
[9] M. Greig,et al. Development of a novel LC/MS method to quantitate cellular stearoyl-CoA desaturase activity. , 2008, Analytica chimica acta.
[10] X. Deng,et al. Dysregulation of sterol regulatory element binding protein-1c in livers of morbidly obese women is associated with altered suppressor of cytokine signaling-3 and signal transducer and activator of transcription-1 signaling. , 2010, Metabolism: clinical and experimental.
[11] Key role of the ERK1/2 MAPK pathway in the transcriptional regulation of the Stearoyl-CoA Desaturase (SCD1) gene expression in response to leptin , 2010, Molecular and Cellular Endocrinology.
[12] R. A. Igal. Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer. , 2010, Carcinogenesis.
[13] K. Mak,et al. Leptin enhances α1(I) collagen gene expression in LX‐2 human hepatic stellate cells through JAK‐mediated H2O2‐dependent MAPK pathways , 2006, Journal of cellular biochemistry.
[14] K. Dahlman-Wright,et al. Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice. , 2008, American journal of physiology. Endocrinology and metabolism.
[15] R. A. Igal,et al. Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis. , 2008, International journal of oncology.
[16] J. Fargnoli,et al. Cancer Cell Dependence on Unsaturated Fatty Acids Implicates Stearoyl-CoA Desaturase as a Target for Cancer Therapy , 2011, Molecular Cancer Research.
[17] Association between serum trans-monounsaturated fatty acids and breast cancer risk in the E3N-EPIC Study. , 2008, American journal of epidemiology.
[18] M. Gariboldi,et al. Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats. , 2002, Carcinogenesis.
[19] J. Lampe,et al. Erythrocyte fatty acids and breast cancer risk: a case-control study in Shanghai, China. , 2007, The American journal of clinical nutrition.
[20] M. Makuuchi,et al. Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma. , 2005, European journal of cancer.
[21] K. Dahlman-Wright,et al. Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3. , 2006, Molecular endocrinology.
[22] S. Fesik,et al. Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen. , 2007, Cancer research.
[23] K. Coombes,et al. Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer , 2011, Clinical Proteomics.
[24] E. Riboli,et al. Fatty acid composition in serum phospholipids and risk of breast cancer: A prospective cohort study in northern sweden , 2007, Lipids.
[25] N. Habib,et al. Partial characterization of a cDNA for human stearoyl‐CoA desaturase and changes in its mRNA expression in some normal and malignant tissues , 1994, International journal of cancer.
[26] F. Berrino,et al. Erythrocyte membrane fatty acids and subsequent breast cancer: a prospective Italian study. , 2001, Journal of the National Cancer Institute.
[27] J. Ntambi,et al. Nuclear factor 1 is essential for the expression of stearoyl-CoA desaturase 1 gene during preadipocyte differentiation. , 1998, Biochimica et biophysica acta.
[28] C. Couet,et al. Prognostic significance of tumor phosphatidylcholine stearic acid level in breast carcinoma , 1991, Breast Cancer Research and Treatment.
[29] Anne E Carpenter,et al. mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway , 2011, Cell.
[30] D. Hess,et al. Inhibition of StearoylCoA Desaturase Activity Blocks Cell Cycle Progression and Induces Programmed Cell Death in Lung Cancer Cells , 2010, PloS one.
[31] H. Enoch,et al. Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid. , 1976, The Journal of biological chemistry.
[32] S. Culine,et al. Abrogation of De novo Lipogenesis by Stearoyl-CoA Desaturase 1 Inhibition Interferes with Oncogenic Signaling and Blocks Prostate Cancer Progression in Mice , 2010, Molecular Cancer Therapeutics.
[33] Qicheng Ma,et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. , 2010, Molecular cell.
[34] G. Mills,et al. Rapamycin Regulates Stearoyl CoA Desaturase 1 Expression in Breast Cancer , 2010, Molecular Cancer Therapeutics.
[35] M. Lane,et al. Cell-free transcription directed by the 422 adipose P2 gene promoter: activation by the CCAAT/enhancer binding protein. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[36] J. Caviglia,et al. High stearoyl-CoA desaturase protein and activity levels in simian virus 40 transformed-human lung fibroblasts. , 2005, Biochimica et biophysica acta.
[37] P. Pandolfi,et al. Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. , 2009, Cancer cell.
[38] G. Hortobagyi,et al. Predictors of tumor progression during neoadjuvant chemotherapy in breast cancer. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[39] Margaret S. Wu,et al. Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1. , 2005, The Journal of clinical investigation.
[40] G. Mills,et al. PIK3CA/PTEN Mutations and Akt Activation As Markers of Sensitivity to Allosteric mTOR Inhibitors , 2012, Clinical Cancer Research.
[41] J. Fuscoe,et al. Detection of early gene expression changes by differential display in the livers of mice exposed to dichloroacetic acid. , 2001, Carcinogenesis.
[42] B. Cohen,et al. Modulation of Insulin Activities by Leptin , 1996, Science.
[43] C. Mounier,et al. Role of the PI3-kinase/mTor pathway in the regulation of the stearoyl CoA desaturase (SCD1) gene expression by insulin in liver , 2007, Journal of Cell Communication and Signaling.
[44] K. Dahlman-Wright,et al. Evidence that oestrogen receptor-α plays an important role in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver , 2006, Diabetologia.
[45] J. Ntambi,et al. Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. , 1989, Genes & development.