Expression of viral p21ras during acquisition of a transformed phenotype by rat adrenal cortex cells infected with Kirsten murine sarcoma virus

Rat adrenal cortex cells infected with Kirsten murine sarcoma virus acquire a transformed phenotype in a progressive fashion. The expression of the viral p21ras does not appear to correlate with the degree of transformation of the adrenocortical cells but rather is produced at similar levels as the culture becomes transformed. This indicates that the expression of an oncogenic form of p21ras is not of itself sufficient to completely transform rat adrenal cortex cells.

[1]  S. Aaronson,et al.  Myeloid cell transformation by ras-containing murine sarcoma viruses , 1985, Molecular and cellular biology.

[2]  S. Yuspa,et al.  Keratinocytes blocked in phorbol ester-responsive early stage of terminal differentiation by sarcoma viruses , 1985, Nature.

[3]  J. Willey,et al.  Transformation of human bronchial epithelial cells transfected by Harvey ras oncogene. , 1985, Science.

[4]  K K Sanford,et al.  Neoplastic transformation of human epidermal keratinocytes by AD12-SV40 and Kirsten sarcoma viruses. , 1985, Science.

[5]  D. Boettiger,et al.  myc and src oncogenes have complementary effects on cell proliferation and expression of specific extracellular matrix components in definitive chondroblasts , 1985, Molecular and cellular biology.

[6]  M. Wigler,et al.  In yeast, RAS proteins are controlling elements of adenylate cyclase , 1985, Cell.

[7]  T. Graf,et al.  Autocrine growth induced by src-related oncogenes in transformed chicken myeloid cells , 1984, Cell.

[8]  T. Graf,et al.  src- and fps-containing avian sarcoma viruses transform chicken erythroid cells. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[9]  H. Kung,et al.  Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein , 1984, Nature.

[10]  D. Spandidos,et al.  Malignant transformation of early passage rodent cells by a single mutated human oncogene , 1984, Nature.

[11]  J. Feramisco,et al.  Microinjection of the oncogene form of the human H-ras (t-24) protein results in rapid proliferation of quiescent cells , 1984, Cell.

[12]  D. Boettiger,et al.  Continuous in vitro generation of multipotential stem cell clones from src-infected cultures , 1984, Nature.

[13]  G. Evan,et al.  Subcellular localization of proteins encoded by oncogenes of avian myeloblastosis virus and avian leukemia virus E26 and by the chicken c-myb gene , 1984, Cell.

[14]  N. Auersperg,et al.  Development of serum independence in Kirsten murine sarcoma virus-infected rat adrenal cells. , 1984, Carcinogenesis.

[15]  H. Ruley.  Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture , 1983, Nature.

[16]  Robert A. Weinberg,et al.  Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes , 1983, Nature.

[17]  H. Varmus,et al.  A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells , 1983, Nature.

[18]  S. Ziegler,et al.  Progression of the transformed phenotype in clonal lines of Abelson virus-infected lymphocytes , 1983, Molecular and cellular biology.

[19]  J. Bishop.  Cellular oncogenes and retroviruses. , 1983, Annual review of biochemistry.

[20]  Kenji Shimizu,et al.  Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change , 1982, Nature.

[21]  M. Barbacid,et al.  Oncogenes in solid human tumours , 1982, Nature.

[22]  Cori Bargmann,et al.  Mechanism of activation of a human oncogene , 1982, Nature.

[23]  D. Lowy,et al.  Comparative biochemical properties of p21 ras molecules coded for by viral and cellular ras genes , 1982, Journal of virology.

[24]  E. Scolnick,et al.  Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family , 1982, Journal of virology.

[25]  E. Scolnick,et al.  Identification of a precursor in the biosynthesis of the p21 transforming protein of harvey murine sarcoma virus , 1982, Journal of virology.

[26]  G. Sherbet.  The biology of tumour malignancy , 1982 .

[27]  O. Witte,et al.  Abelson virus-infected cells can exhibit restricted in vitro growth and low oncogenic potential , 1981, Journal of virology.

[28]  N. Auersperg,et al.  Epidermal growth factors enhances viral transformation of granulosa cells. , 1981, Science.

[29]  N. Auersperg,et al.  Morphological and functional differentiation of Kirsten murine sarcoma virus-transformed rat adrenocortical cell lines. , 1981, Cancer research.

[30]  B. Schimmer.  Cyclic nucleotides in hormonal regulation of adrenocortical function. , 1980, Advances in cyclic nucleotide research.

[31]  N. Auersperg,et al.  Transformation of cultured rat adrenocortical cells by kirsten murine sarcoma virus (ki‐msv) , 1977, International journal of cancer.

[32]  N. Auersperg,et al.  Steroidogenic pathways and trophic response to adrenocorticotrophin of cultured adrenocortical cells in different states of differentiation. , 1976, The Journal of endocrinology.