Is there evidence to show that daily antibiotic treatment is best?

EDITOR,—The recent guidelines on preventing and managing infection in patients with an absent or dysfunctional spleen recommend lifelong prophylaxis with oral antibiotics for all patients who have undergone splenectomy.1 People who receive this advice may ask about their baseline risk of dangerous sepsis, how this will be reduced by taking medicine every day, and other options for prevention. The risk of serious …