Quinolone antimicrobial agents

Introduction Structure-Activity relationships Mechanisms of quinolone action and bacterial killing Quinolone-DNA interaction Mechanisms of bacterial resistance to quinolones Clinical resistance in clinical practice: occurrence and importance Quinolones and eukaryotic topoisomerases Activity in vitro of the quinolones Pharmacokinetics and tissue concentrations in normal persons Pharmacokinetics of fluoroquinolones in selected populations Drug-drug interactions with fluoroquinolone antimicrobial agents Pharmacodynamics of the fluoroquinolones Treatment of urinry tract infections with quinolone antimicrobial agents Role of quinolones in treatment of chronic bacterial prostatitis Use of quinolones in sexually transmitted diseases Use of the quinolones for treatment and prophylaxis of bacterial gastrointestinal infections Treatment of respiratory tract infections with quinolone antimicrobial agents Treatment of infections of the ears, nose and throat, and nasal carriage Use of quinolones for treatment of osteomyelitis and septic arthritis Treatment of bacterial meningitis Treatment of experimental and human bacterial endocarditis with quinolone antimicrobial agents Treatment of skin and soft tissue infections with quinolone antimicrobial agents Treatment of eye infections Use of quinolone antimicrobial agents in immunocompromised patients Veterinary use of quinolones Adverse effects Effects of quinolones on the central nervous system Effetcs of quinolones on the immune system Conclusions and summary