Replication—The Synthesis of DNA

In their famous, historic paper describing the double helix, Watson and Crick concluded: “It has not escaped our notice that the specific pairing we have postulated immediately suggests a copying mechanism for the genetic material.” In a subsequent paper, the authors elaborated on this statement by proposing that the copying mechanism may involve each DNA strand serving as a template for synthesis of a complementary strand.

[1]  D. Lilley,et al.  DNA replication, 2nd edn , 1992 .

[2]  Z. Kelman,et al.  DNA polymerase III holoenzyme: structure and function of a chromosomal replicating machine. , 1995, Annual review of biochemistry.

[3]  E. Friedberg.  Relationships between DNA repair and transcription. , 1996, Annual review of biochemistry.

[4]  I. Wilmut,et al.  "Viable Offspring Derived from Fetal and Adult Mammalian Cells" (1997), by Ian Wilmut et al. , 2014 .

[5]  R. Wood.  DNA repair in eukaryotes. , 1996, Annual review of biochemistry.

[6]  R. Knippers,et al.  Structure of replicating chromatin. , 1996, Progress in nucleic acid research and molecular biology.

[7]  T. Steitz,et al.  Function and structure relationships in DNA polymerases. , 1994, Annual review of biochemistry.

[8]  T. Lohman,et al.  Escherichia coli single-stranded DNA-binding protein: multiple DNA-binding modes and cooperativities. , 1994, Annual review of biochemistry.

[9]  R A Laskey,et al.  Regulation of eukaryotic DNA replication. , 1994, Annual review of biochemistry.

[10]  T. Okazaki,et al.  Discontinuous DNA replication. , 1980, Annual review of biochemistry.

[11]  P. Modrich,et al.  Mismatch repair in replication fidelity, genetic recombination, and cancer biology. , 1996, Annual review of biochemistry.

[12]  L. Pearl,et al.  The structural basis of specific base-excision repair by uracil–DNA glycosylase , 1996, Nature.

[13]  K. Bjornson,et al.  Mechanisms of helicase-catalyzed DNA unwinding. , 1996, Annual review of biochemistry.