Metastasis: from dissemination to organ-specific colonization

[1]  John Condeelis,et al.  Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis , 2006, Cell.

[2]  R. Weil,et al.  Breast cancer metastasis to the central nervous system. , 2005, The American journal of pathology.

[3]  Jean-Philippe Brunet,et al.  The melanocyte differentiation program predisposes to metastasis after neoplastic transformation , 2005, Nature Genetics.

[4]  R. Eils,et al.  Systemic spread is an early step in breast cancer. , 2008, Cancer cell.

[5]  C. Klein.  The systemic progression of human cancer: a focus on the individual disseminated cancer cell--the unit of selection. , 2003, Advances in cancer research.

[6]  J. Segall,et al.  Cell Motility and Cytoskeletal Regulation in Invasion and Metastasis , 2007, Journal of Mammary Gland Biology and Neoplasia.

[7]  J. Ptak,et al.  High Frequency of Mutations of the PIK3CA Gene in Human Cancers , 2004, Science.

[8]  C. Eng,et al.  Targeted therapy for uveal melanoma. , 2008, Cancer treatment reviews.

[9]  T. Dimpfl,et al.  Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. , 2000, The New England journal of medicine.

[10]  Ajit Varki,et al.  Molecular basis of metastasis. , 2009, The New England journal of medicine.

[11]  William Pao,et al.  MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib , 2007, Proceedings of the National Academy of Sciences.

[12]  R Wieser,et al.  TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. , 1999, The Journal of clinical investigation.

[13]  W. Gerald,et al.  Endogenous human microRNAs that suppress breast cancer metastasis , 2008, Nature.

[14]  Ruud H. Brakenhoff,et al.  Dissecting the metastatic cascade , 2004, Nature Reviews Cancer.

[15]  E. Feuer,et al.  SEER Cancer Statistics Review, 1975-2003 , 2006 .

[16]  J. Roth,et al.  Survival in early-stage non-small cell lung cancer. , 1995, The Annals of thoracic surgery.

[17]  R. Eils,et al.  Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer. , 2005, Cancer cell.

[18]  Masahiko Zuka,et al.  Platelet glycoprotein Ibα supports experimental lung metastasis , 2007, Proceedings of the National Academy of Sciences.

[19]  S. Rafii,et al.  The bone marrow vascular niche: home of HSC differentiation and mobilization. , 2005, Physiology.

[20]  Stephen Pulman,et al.  Building the Framework , 1996 .

[21]  Andy J. Minn,et al.  Genes that mediate breast cancer metastasis to lung , 2005, Nature.

[22]  T. Fleming,et al.  Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. , 2001, The New England journal of medicine.

[23]  R. Tibshirani,et al.  Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[24]  K. Luzzi,et al.  Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. , 1998, The American journal of pathology.

[25]  W. Muller,et al.  Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. , 2004, Cancer cell.

[26]  R. Weinberg,et al.  Tumour invasion and metastasis initiated by microRNA-10b in breast cancer , 2007, Nature.

[27]  Debashis Ghosh,et al.  EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[28]  Y. Nakamura,et al.  Genetic alterations during colorectal-tumor development. , 1988, The New England journal of medicine.

[29]  J. Nesland,et al.  Isolated Tumor Cells in Bone Marrow Three Years after Diagnosis in Disease-Free Breast Cancer Patients Predict Unfavorable Clinical Outcome1 , 2004, Clinical Cancer Research.

[30]  C. Bucana,et al.  The seed and soil hypothesis: vascularisation and brain metastases. , 2002, The Lancet. Oncology.

[31]  J. Erler,et al.  Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. , 2009, Cancer cell.

[32]  L. Rubinstein,et al.  Sites of recurrence in resected stage I non-small-cell lung cancer: a guide for future studies. , 1984, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[33]  H. Hansen,et al.  Lung cancer. , 1990, Cancer chemotherapy and biological response modifiers.

[34]  Z. Werb,et al.  GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. , 2008, Cancer cell.

[35]  Ross Tubo,et al.  Mesenchymal stem cells within tumour stroma promote breast cancer metastasis , 2007, Nature.

[36]  G. Christofori.  New signals from the invasive front , 2006, Nature.

[37]  T. Giordano,et al.  NF-κB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF , 2007, Nature Medicine.

[38]  J. Minna,et al.  A big step in the study of small cell lung cancer. , 2003, Cancer cell.

[39]  Wei Wei,et al.  Metastatic patterns in adenocarcinoma , 2006, Cancer.

[40]  R. Vessella,et al.  Cancer micrometastasis and tumour dormancy   , 2008, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[41]  E. Ruoslahti,et al.  Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. , 2004, Cancer cell.

[42]  Mitchell D Schnall,et al.  Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis. , 2002, Cancer cell.

[43]  L. Akslen,et al.  Role of Angiogenesis in Human Tumor Dormancy: Animal Models of the Angiogenic Switch , 2006, Cell cycle.

[44]  W. Gerald,et al.  Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. , 2005, The Journal of clinical investigation.

[45]  C. Cordon-Cardo,et al.  A multigenic program mediating breast cancer metastasis to bone. , 2003, Cancer cell.

[46]  Annuska M Glas,et al.  Gene expression profiles of primary breast tumors maintained in distant metastases , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[47]  Edi Brogi,et al.  ID genes mediate tumor reinitiation during breast cancer lung metastasis , 2007, Proceedings of the National Academy of Sciences.

[48]  M. Grossbard,et al.  Metastatic pancreatic cancer 2008: is the glass less empty? , 2008, The oncologist.

[49]  Jaime Pujadas Oláno,et al.  Natural history of early localized prostate cancer. , 2004, JAMA.

[50]  T. Fehm,et al.  A pooled analysis of bone marrow micrometastasis in breast cancer. , 2005, The New England journal of medicine.

[51]  Andrew J Ewald,et al.  Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis. , 2008, Developmental cell.

[52]  B. Vogelstein,et al.  A genetic model for colorectal tumorigenesis , 1990, Cell.

[53]  Eric S. Lander,et al.  Genomic analysis of metastasis reveals an essential role for RhoC , 2000, Nature.

[54]  D J Ferguson,et al.  Dormancy of mammary carcinoma after mastectomy. , 1999, Journal of the National Cancer Institute.

[55]  E. Lander,et al.  A molecular signature of metastasis in primary solid tumors , 2003, Nature Genetics.

[56]  S. Dhanasekaran,et al.  The polycomb group protein EZH2 is involved in progression of prostate cancer , 2002, Nature.

[57]  N. Stoecklein,et al.  Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer , 2002, The Lancet.

[58]  J. Aragon-Ching,et al.  CNS Metastasis: An Old Problem in a New Guise , 2007, Clinical Cancer Research.

[59]  R. Demicheli,et al.  Tumour dormancy: findings and hypotheses from clinical research on breast cancer. , 2001, Seminars in cancer biology.

[60]  F. Kelly.  Air pollution: an old problem in a new guise , 1996 .

[61]  J. Aguirre-Ghiso,et al.  ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK). , 2003, Cancer research.

[62]  I. Fidler,et al.  The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited , 2003, Nature Reviews Cancer.

[63]  S. Yagishita,et al.  An Ultrastructural Study , 1979 .

[64]  H. Ishwaran,et al.  Lung metastasis genes couple breast tumor size and metastatic spread , 2007, Proceedings of the National Academy of Sciences.

[65]  Michael Reiss,et al.  MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. , 2009, Cancer cell.

[66]  D. Hanahan,et al.  The Hallmarks of Cancer , 2000, Cell.

[67]  Lei Xu,et al.  GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[68]  D. Ledbetter,et al.  Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. , 1989, Science.

[69]  Brian Bierie,et al.  Tumour microenvironment: TGFβ: the molecular Jekyll and Hyde of cancer , 2006, Nature Reviews Cancer.

[70]  Eran Segal,et al.  Module map of stem cell genes guides creation of epithelial cancer stem cells. , 2008, Cell stem cell.

[71]  S. Curbishley,et al.  Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo. , 2006, World journal of gastroenterology.

[72]  O. Salazar,et al.  Breast Cancer: Metastatic Patterns and Their Prognosis , 1988, Southern medical journal.

[73]  P. Steeg.  Tumor metastasis: mechanistic insights and clinical challenges , 2006, Nature Medicine.

[74]  Joon-Oh Park,et al.  MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling , 2007, Science.

[75]  Yeu‐Tsu N. Lee,et al.  Patterns of metastasis and natural courses of breast carcinoma , 2004, Cancer and Metastasis Reviews.

[76]  Lars Holmgren,et al.  Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression , 1995, Nature Medicine.

[77]  D. Cheresh,et al.  Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis , 2004, The Journal of cell biology.

[78]  G. Goodall,et al.  The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 , 2008, Nature Cell Biology.

[79]  P. Jänne,et al.  Twenty‐five years of clinical research for patients with limited‐stage small cell lung carcinoma in North America , 2002, Cancer.

[80]  I. Macdonald,et al.  Metastasis: Dissemination and growth of cancer cells in metastatic sites , 2002, Nature Reviews Cancer.

[81]  Kedar S Vaidya,et al.  Requirement of KISS1 secretion for multiple organ metastasis suppression and maintenance of tumor dormancy. , 2007, Journal of the National Cancer Institute.

[82]  R. Raychowdhury,et al.  Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype. , 2009, Cancer research.

[83]  A novel mouse model of human breast cancer stem-like cells with high CD44+CD24-/lower phenotype metastasis to human bone. , 2009, Chinese medical journal.

[84]  J. Bishop,et al.  Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response , 2008, Proceedings of the National Academy of Sciences.

[85]  Martin A. Nowak,et al.  Comparative lesion sequencing provides insights into tumor evolution , 2008, Proceedings of the National Academy of Sciences.

[86]  L. Chung,et al.  Modulation of prostate cancer growth in bone microenvironments , 2004, Journal of cellular biochemistry.

[87]  J. Aguirre-Ghiso,et al.  ERKMAPK Activity as a Determinant of Tumor Growth and Dormancy; Regulation by p38SAPK , 2003 .

[88]  V. Quaranta,et al.  Tumor cell α3β1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis , 2004, The Journal of cell biology.

[89]  S. Varambally,et al.  Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer , 2008, Science.

[90]  H. Briele,et al.  Natural history of cutaneous malignant melanoma , 1979, World Journal of Surgery.

[91]  S Paget,et al.  THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST. , 1889 .

[92]  Kishore Guda,et al.  The noncoding RNA, miR‐126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3‐kinase signaling and is frequently lost in colon cancers , 2008, Genes, chromosomes & cancer.

[93]  Quynh-Thu Le,et al.  Lysyl oxidase is essential for hypoxia-induced metastasis , 2006, Nature.

[94]  J. Massagué,et al.  Cancer Metastasis: Building a Framework , 2006, Cell.

[95]  T. Fehm,et al.  Detection of cytokeratin-positive cells in the bone marrow of breast cancer patients undergoing adjuvant therapy , 2006, Breast Cancer Research and Treatment.

[96]  Paula D. Bos,et al.  Mediators of vascular remodelling co-opted for sequential steps in lung metastasis , 2007, Nature.

[97]  S. Karpatkin,et al.  Role of platelets in tumor cell metastases. , 1981, Annals of the New York Academy of Sciences.

[98]  James D Iglehart,et al.  Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. , 2007, Cancer cell.

[99]  B. Echtenacher,et al.  Lysis of tumor cells by natural killer cells in mice is impeded by platelets. , 1999, Cancer research.

[100]  R. Eils,et al.  From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer progression , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[101]  K. Miura,et al.  Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression , 2006, Nature Medicine.

[102]  Wenjun Guo,et al.  The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells , 2008, Cell.

[103]  Ruth J. Muschel,et al.  Coagulation Facilitates Tumor Cell Spreading in the Pulmonary Vasculature during Early Metastatic Colony Formation , 2004, Cancer Research.

[104]  P. Gassmann,et al.  Organ-specific metastatic tumor cell adhesion and extravasation of colon carcinoma cells with different metastatic potential. , 2006, The American journal of pathology.

[105]  B. Döme,et al.  Organ-specificity of the extravasation process: An ultrastructural study , 2004, Clinical & Experimental Metastasis.

[106]  W. Birchmeier,et al.  MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis , 2009, Nature Medicine.

[107]  A. Vortmeyer,et al.  Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization , 2008, Clinical & Experimental Metastasis.

[108]  Yi Zhang,et al.  Genes associated with breast cancer metastatic to bone. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[109]  K. Kinzler,et al.  Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. , 1995, Science.

[110]  George Poste,et al.  The "seed and soil" hypothesis revisited. , 2008, The Lancet. Oncology.

[111]  Harold Varmus,et al.  Seeding and Propagation of Untransformed Mouse Mammary Cells in the Lung , 2008, Science.

[112]  S. Rafii,et al.  VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche , 2005, Nature.

[113]  K. Kinzler,et al.  Lessons from Hereditary Colorectal Cancer , 1996, Cell.

[114]  Daniel A. Haber,et al.  Epidermal growth factor receptor mutations in lung cancer , 2007, Nature Reviews Cancer.

[115]  J. Aguirre-Ghiso,et al.  Green Fluorescent Protein Tagging of Extracellular Signal-Regulated Kinase and p38 Pathways Reveals Novel Dynamics of Pathway Activation during Primary and Metastatic Growth , 2004, Cancer Research.

[116]  G. Mundy.  Metastasis: Metastasis to bone: causes, consequences and therapeutic opportunities , 2002, Nature Reviews Cancer.

[117]  Hiroyuki Aburatani,et al.  The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase , 2008, Nature Cell Biology.

[118]  Robert A. Weinberg,et al.  Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. , 2008, Developmental cell.

[119]  T. Golub,et al.  Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma , 2005, Nature.

[120]  K. Pantel,et al.  Molecular mechanisms of metastasis , 2011, Journal of surgical oncology.

[121]  J. Massagué,et al.  Genetic determinants of cancer metastasis , 2007, Nature Reviews Genetics.

[122]  Roger R. Gomis,et al.  TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4 , 2008, Cell.

[123]  Wan-Wan Lin,et al.  Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis , 2009, Nature.

[124]  P. Pharoah,et al.  Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1 , 2005, Nature Genetics.