Pd/PC-Phos-Catalyzed Enantioselective Intermolecular Denitrogenative Cyclization of Benzotriazoles with Allenes or N-allenamides.

Herein we reported an asymmetric Pd/PC-Phos-catalyzed denitrogenative cyclization of benzotriazoles with allennes and N-allenamides, which represents the first example of enantioselective denitrogenative cyclization of benzotriazoles. A series of optically active 3-methyleneindolines were obtained in good yields with high ees. The use of inexpensive and readily available starting materials, high regio- and enantioselectivity, a broad substrate scope, mild reaction conditions, base free, as well as versatile functionalization of the 3-methyleneindoline make this approach quite attractive.

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