The control of fed-batch fermentation processes - A survey

Abstract A survey of the control of fermentation processes operated in fed-batch mode is presented. Truely optimal conditions can only be found by minimizing (or maximizing) a cost criterion subject to the constraints imposed by a mathematical model of the process. This approach leads to the design of a tracking controller, or servomechanism as it is also called. A different approach uses a physiological model of the process to determine a control strategy, which results in keeping a measured or estimated variable at its set-point by means of a regulator.

[1]  Suteaki Shioya,et al.  Measurement of State Variables and Controlling Biochemical Reaction Processes , 1983 .

[2]  Dane W. Zabriskie.  REAL‐TIME APPLICATIONS OF COMPUTERS IN FERMENTATION PROCESSES , 1979 .

[3]  J Stanissis,et al.  An adaptive control algorithm for fed‐batch culture , 1984, Biotechnology and bioengineering.

[4]  Per Hagander,et al.  Computer Control of Sucrose Concentration in a Fermentor with Continuos Flow , 1982 .

[5]  C L Cooney,et al.  Computer‐aided material balancing for prediction of fermentation parameters , 1977, Biotechnology and bioengineering.

[6]  K C Chen,et al.  On‐line optimal control for fed‐batch culture of baker's yeast production , 1985, Biotechnology and bioengineering.

[7]  T. Nakamura,et al.  Fuzzy Control Application to Glutamic Acid Fermentation , 1985 .

[8]  Charles L. Cooney,et al.  Computer control of bakers' yeast production , 1979 .

[9]  Marie-Noëlle Pons,et al.  A MICRO-MINI COMPUTER HIERARCHICAL CONTROL SYSTEM FOR A LABORATORY SCALE FERMENTOR , 1983 .

[10]  S Shioya,et al.  Optimal quality control of bakers' yeast fed‐batch culture using population dynamics , 1982, Biotechnology and bioengineering.

[11]  D. S. Flynn.  Instrumentation for Fermentation Processes , 1983 .

[12]  Peter D. Roberts,et al.  On an algorithm for combined system optimisation and parameter estimation , 1981, Autom..

[13]  Suteaki Shioya,et al.  Experimental Study of Time-Optimal Control in Fed-Batch Culture of Bakers' Yeast , 1982 .

[14]  M. Voetter,et al.  Adaptive Control of a Fed-batch Baker's Yeast Fermentation , 1985 .

[15]  W Y Svrcek,et al.  The extended Kalman filter applied to a continuous culture model , 1974, Biotechnology and bioengineering.

[16]  Lilia Alberghina,et al.  ANALYSIS OF PROTEIN DISTRIBUTION IN POPULATIONS OF BUDDING YEAST BASED ON A STRUCTURED MODEL OF CELL GROWTH , 1983 .

[17]  Ichiro Inoue,et al.  OPTIMAL OPERATION FOR THE SEED CULTURE PROCESS , 1982 .

[18]  Suteaki Shioya,et al.  An advanced micro-computer coupled control system in a baker's yeast fed-batch culture using a tubing method , 1983 .

[19]  Gregory Stephanopoulos,et al.  STATE ESTIMATION FOR COMPUTER CONTROL OF BIOCHEMICAL REACTORS , 1981 .

[20]  Fishman Vm,et al.  Kinetic model of secondary metabolite production and its use in computation of optimal conditions. , 1974 .

[21]  R. M. Dekkers.  Optimal control of a fed-batch fermentation , 1984 .

[22]  R. M. Dekkers.  State Estimation of a Fed-Batch Baker's Yeast Fermentation , 1983 .

[23]  S Nagai,et al.  Fed batch culture of Saccharomyces cerevisiae: A perspective of computer control to enhance the productivity in baker's yeast cultivation , 1976, Biotechnology and bioengineering.

[24]  C L Cooney,et al.  Growth monitoring and control through computer‐aided on‐line mass balancing in a fed‐batch penicillin fermentation , 1983, Biotechnology and bioengineering.

[25]  P Peringer,et al.  Modeling and optimal control of bakers yeast production in repeated fed batch culture , 1980 .

[26]  R. E. Kalman,et al.  Contributions to the Theory of Optimal Control , 1960 .

[27]  Michimasa Kishimoto,et al.  Optimization of a Fed-batch Culture by Statistical Data Analysis , 1983 .

[28]  Denis Dochain,et al.  Adaptive identification and control algorithms for nonlinear bacterial growth systems , 1984, Autom..

[29]  P. R. Kumar,et al.  Optimal Adaptive Control of Linear-Quadratic-Gaussian Systems , 1983 .

[30]  J. L. Calvet,et al.  Static Optimization of the Ethanol Production in a Cascade Reactor , 1983 .

[31]  Panu Harmo,et al.  Real-Time Growth Estimation in Batch Fermentation , 1984 .

[32]  Cha Yong Choi,et al.  Control of sugar feeding for glutamic acid fermentation , 1984 .

[33]  A. Halme,et al.  Application of Control Engineering to Fermentation Processes , 1978 .

[34]  D I Wang,et al.  Computer control of the penicillin fermentation using the filtration probe in conjunction with a structured process model , 1983, Biotechnology and bioengineering.

[35]  Jukka Ranta,et al.  Procedures for parameter and state estimation of microbial growth process models , 1982, Autom..

[36]  C. L. Cooney,et al.  APPLICATION OF COMPUTER CONTROL TO YEAST FERMENTATION , 1983 .

[37]  M. B. Beck,et al.  Fuzzy control of the activated sludge wastewater treatment process , 1980, Autom..

[38]  T. Takamatsu,et al.  Optimal control of a semibatch fermentation , 1976, Biotechnology and bioengineering.