Training FCNs model with lesion-size-unified dermoscopy images for lesion segmentation

Dermoscopy is an important noninvasive diagnostic technique for early detection of melanoma that is the deadliest form of skin cancer. Lesion segmentation is a critical step in analyzing dermoscopy images. An obvious characteristic of the lesions in dermoscopy images is appearing in multi-size, and it becomes a serious barrier to improve the lesion segmentation while using fully convolutional neural networks (FCNs) model, which is a popular tool to carry off this challenging task. In this paper, we propose a method to unify the lesion sizes among various dermoscopy images and use the unified images to train the FCNs model. The method was tested on PH2 and ISIC2017 dataset, and the results of experiments show that using the lesion-size-unified dermoscopy images can greatly improve the segmentation performance. This work is of value on assisting artificial delineation, revealing the relations between performance and various lesion sizes, and guiding significance for preprocessing of input dermoscopy images while using FCNs model.

[1]  Sergey Ioffe,et al.  Batch Normalization: Accelerating Deep Network Training by Reducing Internal Covariate Shift , 2015, ICML.

[2]  K Wolff,et al.  In vivo epiluminescence microscopy: improvement of early diagnosis of melanoma. , 1993, The Journal of investigative dermatology.

[3]  A. Jemal,et al.  Cancer statistics in China, 2015 , 2016, CA: a cancer journal for clinicians.

[4]  N. Otsu A threshold selection method from gray level histograms , 1979 .

[5]  Rita Cucchiara,et al.  Comparison of color clustering algorithms for segmentation of dermatological images , 2006, SPIE Medical Imaging.

[6]  Rita Cucchiara,et al.  A new algorithm for border description of polarized light surface microscopic images of pigmented skin lesions , 2003, IEEE Transactions on Medical Imaging.

[7]  W. Stoecker,et al.  Unsupervised border detection in dermoscopy images , 2007, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[8]  A. Jemal,et al.  Cancer statistics, 2018 , 2018, CA: a cancer journal for clinicians.

[9]  Huiyu Zhou,et al.  A State-of-the-Art Survey on Lesion Border Detection in Dermoscopy Images , 2015 .

[10]  Andrew Zisserman,et al.  Very Deep Convolutional Networks for Large-Scale Image Recognition , 2014, ICLR.

[11]  Pedro M. Ferreira,et al.  PH2 - A dermoscopic image database for research and benchmarking , 2013, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[12]  Thomas Brox,et al.  U-Net: Convolutional Networks for Biomedical Image Segmentation , 2015, MICCAI.

[13]  Yi Yang,et al.  Attention to Scale: Scale-Aware Semantic Image Segmentation , 2015, 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[14]  Roberto Cipolla,et al.  SegNet: A Deep Convolutional Encoder-Decoder Architecture for Image Segmentation , 2015, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[15]  David Dagan Feng,et al.  Automatic Skin Lesion Analysis using Large-scale Dermoscopy Images and Deep Residual Networks , 2017, ArXiv.

[16]  Ali Gooya,et al.  Segmentation of Lesions in Dermoscopy Images Using Saliency Map And Contour Propagation , 2017, ArXiv.

[17]  Su Buqing,et al.  Affine differential geometry , 1983 .

[18]  B. Thiers,et al.  Dermoscopy compared with naked eye examination for the diagnosis of primary melanoma: a meta-analysis of studies performed in a clinical setting , 2009 .

[19]  M. G. Fleming,et al.  Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet. , 2003, Journal of the American Academy of Dermatology.

[20]  Noel C. F. Codella,et al.  Skin lesion analysis toward melanoma detection: A challenge at the 2017 International symposium on biomedical imaging (ISBI), hosted by the international skin imaging collaboration (ISIC) , 2016, 2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018).

[21]  Silvija Duma Dermoscopy of Pigmented Skin Lesions , 2015 .

[22]  H. Kittler,et al.  Diagnostic accuracy of dermoscopy. , 2002, The Lancet. Oncology.