Development and Characterization of Drug Loaded PVA/PCL Fibres for Wound Dressing Applications

Nowadays, synthetic polymers are used in medical applications due to their special biodegradable, biocompatible, hydrophilic, and non-toxic properties. The materials, which can be used for wound dressing fabrication with controlled drug release profile, are the need of the time. The main aim of this study was to develop and characterize polyvinyl alcohol/polycaprolactone (PVA/PCL) fibres containing a model drug. A dope solution comprising PVA/PCL with the drug was extruded into a coagulation bath and became solidified. The developed PVA/PCL fibres were then rinsed and dried. These fibres were tested for Fourier transform infrared spectroscopy, linear density, topographic analysis, tensile properties, liquid absorption, swelling behaviour, degradation, antimicrobial activity, and drug release profile for improved and better healing of the wound. From the results, it was concluded that PVA/PCL fibres containing a model drug can be produced by using the wet spinning technique and have respectable tensile properties; adequate liquid absorption, swelling %, and degradation %; and good antimicrobial activity with the controlled drug release profile of the model drug for wound dressing applications.

[1]  A. Nazir,et al.  Development of Sustainable Hydrophilic Azadirachta indica Loaded PVA Nanomembranes for Cosmetic Facemask Applications , 2023, Membranes.

[2]  Yong Guo,et al.  Membrane-Targeting Neolignan-Antimicrobial Peptide Mimic Conjugates to Combat Methicillin-Resistant Staphylococcus aureus (MRSA) Infections. , 2022, Journal of medicinal chemistry.

[3]  M. Jalalah,et al.  Ginger Loaded Polyethylene Oxide Electrospun Nanomembrane: Rheological and Antimicrobial Attributes , 2022, Membranes.

[4]  Juan Ye,et al.  FIVES: A Fundus Image Dataset for Artificial Intelligence based Vessel Segmentation , 2022, Scientific Data.

[5]  Hao-Jie Zhong,et al.  Beneficial Effects of Repeated Washed Microbiota Transplantation in Children With Autism , 2022, Frontiers in Pediatrics.

[6]  Xiaowei Yu,et al.  Osteoblastic differentiation and bactericidal activity are enhanced by erythromycin released from PCL/PLGA-PVA coaxial nanofibers , 2022, Journal of biomaterials applications.

[7]  Jinming Zhang,et al.  Oral colon-targeted mucoadhesive micelles with enzyme-responsive controlled release of curcumin for ulcerative colitis therapy , 2022, Chinese Chemical Letters.

[8]  Jiawei Lu,et al.  Synthesis and properties of Poly(vinyl alcohol) hydrogels with high strength and toughness , 2022, Polymer Testing.

[9]  Muhammad Irfan,et al.  Dressings for burn wound: a review , 2022, Journal of Materials Science.

[10]  Xiaokun Fan,et al.  A 4arm-PEG macromolecule crosslinked chitosan hydrogels as antibacterial wound dressing. , 2021, Carbohydrate polymers.

[11]  M. Muhammed,et al.  Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers. , 2021, Carbohydrate polymers.

[12]  M. Qadir,et al.  Development and characterization of biodegradable composite film , 2021, Environmental Technology & Innovation.

[13]  Han Wang,et al.  Coaxial electrospun PVA/PCL nanofibers with dual release of tea polyphenols and ε-poly (L-lysine) as antioxidant and antibacterial wound dressing materials. , 2021, International journal of pharmaceutics.

[14]  A. Shahzad,et al.  Development and characterization of biodegradable starch-based fibre by wet extrusion , 2021, Cellulose.

[15]  C. Garrido,et al.  Small molecule DNA-PK inhibitors as potential cancer therapy: a patent review (2010–present) , 2020, Expert opinion on therapeutic patents.

[16]  I. Kim,et al.  An Experimental Study on Modelling the Physical Properties of Composite Psyllium, Alginate and Chitosan Fibers Using Box-Behnken Technique , 2020, Fibers and Polymers.

[17]  Büşra Aksoy,et al.  Preparation of hybrid PU/PCL fibers from steviol glycosides via electrospinning as a potential wound dressing materials , 2020 .

[18]  C. Garrido,et al.  Dual inhibitors of Histone Deacetylases and Other Cancer-Related Targets: A Pharmacological Perspective. , 2020, Biochemical pharmacology.

[19]  Donghyun Lee,et al.  Preparation of PCL/(+)-catechin/gelatin film for wound healing using air-jet spinning , 2020 .

[20]  S. Zhuang,et al.  Terahertz spectroscopy in biomedical field: a review on signal-to-noise ratio improvement , 2020 .

[21]  P. Shende,et al.  Formulation and comparative characterization of nanoparticles of curcumin using natural, synthetic and semi-synthetic polymers for wound healing. , 2020, Life sciences.

[22]  J. Chvojka,et al.  Novel double-layered planar scaffold combining electrospun PCL fibers and PVA hydrogels with high shape integrity and water stability , 2020 .

[23]  L. Applegate,et al.  Implications of chlorhexidine use in burn units for wound healing. , 2020, Burns : journal of the International Society for Burn Injuries.

[24]  T. A. Olusi,et al.  Epidemiology is … , 2019, Essential Epidemiology.

[25]  Xiaqing Zhou,et al.  Controlled released of drug from doubled-walled PVA hydrogel/PCL microspheres prepared by single needle electrospraying method. , 2019, Colloids and surfaces. B, Biointerfaces.

[26]  Shixuan Chen,et al.  A skin-inspired 3D bilayer scaffold enhances granulation tissue formation and anti-infection for diabetic wound healing , 2019, Journal of Materials Chemistry B.

[27]  M. Teodorescu,et al.  Biomaterials of PVA and PVP in medical and pharmaceutical applications: Perspectives and challenges. , 2019, Biotechnology advances.

[28]  E. Mirzaei,et al.  Incorporation of nanofibrillated chitosan into electrospun PCL nanofibers makes scaffolds with enhanced mechanical and biological properties. , 2018, Carbohydrate polymers.

[29]  R. Riaz,et al.  Development of tri-component antibacterial hybrid fibres for potential use in wound care. , 2018, Journal of wound care.

[30]  B. Ramírez-Wong,et al.  Preparation and Properties of Chitosan–PVA Fibers Produced by Wet Spinning , 2018, Journal of Polymers and the Environment.

[31]  D. Puppi,et al.  Wet‐spinning of biomedical polymers: from single‐fibre production to additive manufacturing of three‐dimensional scaffolds , 2017 .

[32]  I. Davies,et al.  PVA, PVA Blends, and Their Nanocomposites for Biodegradable Packaging Application , 2017 .

[33]  T. Hussain,et al.  Development and characterization of alginate-chitosan-hyaluronic acid (ACH) composite fibers for medical applications , 2016, Fibers and Polymers.

[34]  V. V. Padma,et al.  Wound dressings – a review , 2015, BioMedicine.

[35]  T. Hussain,et al.  Development of slow release silver-containing biomaterial for wound care applications , 2015 .

[36]  M. Miraftab,et al.  Novel materials for moist wound management: alginate-psyllium hybrid fibres. , 2014, Journal of wound care.

[37]  Mark W. Carlson,et al.  The importance of both fibroblasts and keratinocytes in a bilayered living cellular construct used in wound healing , 2014, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[38]  M. Miraftab,et al.  Absorbent alginate fibres modified with hydrolysed chitosan for wound care dressings--II. Pilot scale development. , 2014, Carbohydrate polymers.

[39]  N. Ibrahim,et al.  Impact Toughness and Ductility Enhancement of Biodegradable Poly(lactic acid)/Poly(ε-caprolactone) Blends via Addition of Glycidyl Methacrylate , 2013 .

[40]  Zhipeng Gu,et al.  In vitro enzymatic degradation of a biological tissue fixed by alginate dialdehyde. , 2013, Carbohydrate polymers.

[41]  M. Peck.  Epidemiology of burns throughout the world. Part I: Distribution and risk factors. , 2011, Burns : journal of the International Society for Burn Injuries.

[42]  L. Ambrosio,et al.  Natural/synthetic porous scaffold designs and properties for fibro-cartilaginous tissue engineering , 2011 .

[43]  Y. Zhai,et al.  Study on Medical Polyvinyl Alcohol (PVA) / Polyvinyl Pyrrolidone (PVP) Hydrogel Wound Dressing , 2011 .

[44]  Dietmar W. Hutmacher,et al.  Design, fabrication and characterization of PCL electrospun scaffolds—a review , 2011 .

[45]  J. Kennedy,et al.  Antimicrobial Properties of Alginate-Chitosan (Alchite) Fibers Developed for Wound Care Applications , 2011 .

[46]  R. Reis,et al.  Optimized electro‐ and wet‐spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatite , 2011, Journal of tissue engineering and regenerative medicine.

[47]  H. Baltzer,et al.  Collagen fibres by thermoplastic and wet spinning , 2010 .

[48]  T. K. Hunt,et al.  Human skin wounds: A major and snowballing threat to public health and the economy , 2009, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[49]  Shuai Zhang,et al.  PREPARATION OF CELLULOSE/CHITIN BLEND BIO-FIBERS VIA DIRECT DISSOLUTION , 2009 .

[50]  H. Vogel,et al.  Structural biology of bacterial iron uptake. , 2008, Biochimica et biophysica acta.

[51]  René Ranzinger,et al.  Statistical analysis of the Bacterial Carbohydrate Structure Data Base (BCSDB): Characteristics and diversity of bacterial carbohydrates in comparison with mammalian glycans , 2008, BMC Structural Biology.

[52]  Xiaoying Cao,et al.  Fibrous poly(chitosan-g-DL-lactic acid) scaffolds prepared via electro-wet-spinning. , 2008, Acta biomaterialia.

[53]  Geoffrey M. Spinks,et al.  Production of polypyrrole fibres by wet spinning , 2008 .

[54]  Laura A. Poole-Warren,et al.  A photo-crosslinked poly(vinyl alcohol) hydrogel growth factor release vehicle for wound healing applications , 2003, AAPS PharmSci.

[55]  Jöns Hilborn,et al.  Poly(lactic acid) fiber : An overview , 2007 .

[56]  Kee Woei Ng,et al.  In vivo evaluation of an ultra-thin polycaprolactone film as a wound dressing , 2007, Journal of biomaterials science. Polymer edition.

[57]  L. Ambrosio,et al.  A tissue engineering approach to meniscus regeneration in a sheep model. , 2006, Osteoarthritis and cartilage.

[58]  Kyongbum Lee,et al.  Tissue Engineering I , 2006 .

[59]  Cato T Laurencin,et al.  Polymers as biomaterials for tissue engineering and controlled drug delivery. , 2006, Advances in biochemical engineering/biotechnology.

[60]  M. Ahmed,et al.  Characterization of polymeric poly(epsilon-caprolactone) injectable implant delivery system for the controlled delivery of contraceptive steroids. , 2006, Journal of biomedical materials research. Part A.

[61]  David S. Jones,et al.  Physicochemical characterisation and biological evaluation of hydrogel-poly(epsilon-caprolactone) interpenetrating polymer networks as novel urinary biomaterials. , 2005, Biomaterials.

[62]  R. Kaushik,et al.  Poly-ϵ-caprolactone microspheres and nanospheres: an overview , 2004 .

[63]  L. Dao,et al.  A novel electrically conductive and biodegradable composite made of polypyrrole nanoparticles and polylactide. , 2004, Biomaterials.

[64]  I. Um,et al.  Wet spinning of silk polymer. I. Effect of coagulation conditions on the morphological feature of filament. , 2004, International journal of biological macromolecules.

[65]  R. Kaushik,et al.  Poly-epsilon-caprolactone microspheres and nanospheres: an overview. , 2004, International journal of pharmaceutics.

[66]  Ze Zhang,et al.  A biodegradable electrical bioconductor made of polypyrrole nanoparticle/poly(D,L-lactide) composite: A preliminary in vitro biostability study. , 2003, Journal of biomedical materials research. Part A.

[67]  C. Demerlis,et al.  Review of the oral toxicity of polyvinyl alcohol (PVA). , 2003, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[68]  Hua Zheng,et al.  Preparation and characterization of chitosan/poly(vinyl alcohol) blend fibers , 2001 .

[69]  S. Hirano,et al.  Wet spun chitosan-collagen fibers, their chemical N-modifications, and blood compatibility. , 2000, Biomaterials.