Resting‐state functional MRI as a tool for evaluating brain hemodynamic responsiveness to external stimuli in rats

Anesthesia is a major confounding factor in functional MRI (fMRI) experiments attributed to its effects on brain function. Recent evidence suggests that parameters obtained with resting‐state fMRI (rs‐fMRI) are coupled with anesthetic depth. Therefore, we investigated whether parameters obtained with rs‐fMRI, such as functional connectivity (FC), are also directly related to blood‐oxygen‐level–dependent (BOLD) responses.

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