Dapsone-Induced Hemolytic Anemia in a Patient with Relapsing Polychondritis

A 53-year-old woman presented with bilateral auricular chondritis which was responsive to high doses of prednisone. After a diagnosis of relapsing polychondritis was confirmed, she was treated with dapsone. Her disease responded well to dapsone 200 mg daily. While on this regimen, she developed a dapsone-induced hemolytic anemia which was successfully managed by a reduction in dosage. The use of dapsone for relapsing polychondritis and dapsone-induced hemolytic anemia are reviewed.

[1]  H. Levine,et al.  Relapsing polychondritis — REPORT OF TEN CASES , 1979, The Laryngoscope.

[2]  P. Hansotia,et al.  Relapsing polychondritis: unusual neurological findings and therapeutic efficacy of dapsone. , 1979, Archives of dermatology.

[3]  P. Deschamps,et al.  [The treatment of relapsing polychondritis using sulfones. One case (author's transl)]. , 1978, La Nouvelle presse medicale.

[4]  W. Bergfeld.  Relapsing polychondritis with positive direct immunofluorescence. , 1978, Archives of Dermatology.

[5]  H. Solomon,et al.  Treatment of relapsing polychondritis with dapsone. , 1976, Archives of dermatology.

[6]  H. Roenigk,et al.  Relapsing polychondritis treated with dapsone. , 1976, Archives of dermatology.

[7]  David Bruce Lewis,et al.  Anti‐inflammatory actions of dapsone and its related biochemistry , 1976, The Journal of pharmacy and pharmacology.

[8]  A. Masi,et al.  Relapsing polychondritis: review of current status and case report,. , 1975, Seminars in arthritis and rheumatism.

[9]  V. P. Barranco.  Inhibition of lysosomal enzymes by dapsone. , 1974, Archives of dermatology.

[10]  G. Scott,et al.  The Haemolytic Action of Dapsone: The Effect on Red‐Cell Glycolysis , 1973, British journal of haematology.

[11]  G. Scott,et al.  The Haemolytic Action of Dapsone: Changes in the Red‐Cell Membrane , 1973, British journal of haematology.

[12]  J. Cream,et al.  ANAEMIA IN DERMATITIS HERPETIFORMIS , 1970, The British journal of dermatology.

[13]  R. Degowin,et al.  The haemolytic effects of diaphenylsulfone (DDS) in normal subjects and in those with glucose-6-phosphate-dehydrogenase deficiency. , 1966, Bulletin of the World Health Organization.