Multimodal MRI as a diagnostic biomarker for amyotrophic lateral sclerosis

Reliable biomarkers for amyotrophic lateral sclerosis (ALS) are needed, given the clinical heterogeneity of the disease. Here, we provide proof‐of‐concept for using multimodal magnetic resonance imaging (MRI) as a diagnostic biomarker for ALS. Specifically, we evaluated the added diagnostic utility of proton magnetic resonance spectroscopy (MRS) to diffusion tensor imaging (DTI).

[1]  O. Ciccarelli,et al.  Diagnostic accuracy of diffusion tensor imaging in amyotrophic lateral sclerosis: a systematic review and individual patient data meta-analysis. , 2013, Academic radiology.

[2]  Martin G Pomper,et al.  An imbalance between excitatory and inhibitory neurotransmitters in amyotrophic lateral sclerosis revealed by use of 3-T proton magnetic resonance spectroscopy. , 2013, JAMA neurology.

[3]  M. Pomper,et al.  Diagnostic accuracy using diffusion tensor imaging in the diagnosis of ALS: a meta-analysis. , 2012, Academic radiology.

[4]  F. Agosta,et al.  Neuroimaging in amyotrophic lateral sclerosis. , 2012, Biomarkers in medicine.

[5]  T L Chenevert,et al.  Decreased motor cortex γ-aminobutyric acid in amyotrophic lateral sclerosis , 2012, Neurology.

[6]  M. Turner,et al.  Does interneuronal dysfunction contribute to neurodegeneration in amyotrophic lateral sclerosis? , 2012, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

[7]  Steven Knight,et al.  Integration of structural and functional magnetic resonance imaging in amyotrophic lateral sclerosis. , 2011, Brain : a journal of neurology.

[8]  Andrew Simmons,et al.  Magnetic resonance imaging and magnetic resonance spectroscopy for detection of early Alzheimer's disease. , 2011, Journal of Alzheimer's disease : JAD.

[9]  Martin R. Turner,et al.  Biomarkers in amyotrophic lateral sclerosis: opportunities and limitations , 2011, Nature Reviews Neurology.

[10]  M. Inghilleri,et al.  Clinical neurophysiology in ALS. , 2011, Archives italiennes de biologie.

[11]  M. Lauritzen,et al.  Reduced GABAergic inhibition explains cortical hyperexcitability in the wobbler mouse model of ALS. , 2011, Cerebral cortex.

[12]  N Filippini,et al.  Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis , 2010, Neurology.

[13]  A. Zwinderman,et al.  MR Spectroscopy Findings in Early Stages of Motor Neuron Disease , 2010, American Journal of Neuroradiology.

[14]  M. Filippi,et al.  The Present and the Future of Neuroimaging in Amyotrophic Lateral Sclerosis , 2010, American Journal of Neuroradiology.

[15]  P. Berlit,et al.  Diagnostic problems and delay of diagnosis in amyotrophic lateral sclerosis , 2010, Clinical Neurology and Neurosurgery.

[16]  L. Concha,et al.  Combined structural and neurochemical evaluation of the corticospinal tract in amyotrophic lateral sclerosis , 2010, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

[17]  D. Montanaro,et al.  Diffusion tensor MRI and MR spectroscopy in long lasting upper motor neuron involvement in amyotrophic lateral sclerosis. , 2009, Archives italiennes de biologie.

[18]  P. Matthews,et al.  Polarity-Sensitive Modulation of Cortical Neurotransmitters by Transcranial Stimulation , 2009, The Journal of Neuroscience.

[19]  Michel Dib,et al.  Biomarkers in Amyotrophic Lateral Sclerosis , 2009, Molecular Diagnosis & Therapy.

[20]  H. Urbach,et al.  Combined 3T Diffusion Tensor Tractography and 1H-MR Spectroscopy in Motor Neuron Disease , 2008, American Journal of Neuroradiology.

[21]  S L Pullman,et al.  Quantitative objective markers for upper and lower motor neuron dysfunction in ALS , 2007, Neurology.

[22]  E. Beghi,et al.  Predictors of delay in the diagnosis and clinical trial entry of amyotrophic lateral sclerosis patients: A population-based study , 2006, Journal of the Neurological Sciences.

[23]  M. Kiernan,et al.  Novel threshold tracking techniques suggest that cortical hyperexcitability is an early feature of motor neuron disease. , 2006, Brain : a journal of neurology.

[24]  C. Hanstock,et al.  Detection of cerebral degeneration in amyotrophic lateral sclerosis using high-field magnetic resonance spectroscopy. , 2006, Archives of neurology.

[25]  Elias R Melhem,et al.  Amyotrophic lateral sclerosis: diffusion-tensor and chemical shift MR imaging at 3.0 T. , 2006, Radiology.

[26]  N. Perkins,et al.  The inconsistency of "optimal" cutpoints obtained using two criteria based on the receiver operating characteristic curve. , 2006, American journal of epidemiology.

[27]  P. Szeszko,et al.  MRI atlas of human white matter , 2006 .

[28]  A Al-Chalabi,et al.  Abnormal cortical excitability in sporadic but not homozygous D90A SOD1 ALS , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[29]  Christian Gluud,et al.  Evidence based diagnostics , 2005, BMJ : British Medical Journal.

[30]  F. Turkheimer,et al.  Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study , 2004, Neurobiology of Disease.

[31]  Derek K. Jones,et al.  The effect of gradient sampling schemes on measures derived from diffusion tensor MRI: A Monte Carlo study † , 2004, Magnetic resonance in medicine.

[32]  S. Petri,et al.  Distribution of GABAA Receptor mRNA in the Motor Cortex of ALS Patients , 2003, Journal of neuropathology and experimental neurology.

[33]  D. Sackett,et al.  The architecture of diagnostic research , 2002, BMJ : British Medical Journal.

[34]  M. Swash,et al.  Diagnostic delay in amyotrophic lateral sclerosis: what scope for improvement? , 2000, Journal of the Neurological Sciences.

[35]  P M Pattany,et al.  MR imaging and localized proton spectroscopy of the precentral gyrus in amyotrophic lateral sclerosis. , 2000, AJNR. American journal of neuroradiology.

[36]  M. Swash,et al.  El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis , 2000, Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases.

[37]  L. Leocani,et al.  Neuroimaging in amyotrophic lateral sclerosis , 1999, European journal of neurology.

[38]  M A Horsfield,et al.  Diffusion tensor MRI assesses corticospinal tract damage in ALS , 1999, Neurology.

[39]  M. Garwood,et al.  Simultaneous in vivo spectral editing and water suppression , 1998, NMR in biomedicine.

[40]  F Träber,et al.  Proton magnetic resonance spectroscopy of the primary motor cortex in patients with motor neuron disease: subgroup analysis and follow-up measurements. , 1998, Archives of neurology.

[41]  M. Warmuth-Metz,et al.  The corticospinal tract in amyotrophic lateral sclerosis: An MRI study , 1998, Neuroradiology.

[42]  M. Bromberg,et al.  A self report measure of affective lability , 1997, Journal of neurology, neurosurgery, and psychiatry.

[43]  S. Provencher.  Estimation of metabolite concentrations from localized in vivo proton NMR spectra , 1993, Magnetic resonance in medicine.

[44]  A. Eisen,et al.  Duration of amyotrophic lateral sclerosis is age dependent , 1993, Muscle & nerve.

[45]  Richard W. Bohannon,et al.  Interrater reliability of a modified Ashworth scale of muscle spasticity. , 1987, Physical therapy.

[46]  H. Alkadhi,et al.  Localization of the motor hand area to a knob on the precentral gyrus. A new landmark. , 1997, Brain : a journal of neurology.

[47]  M. Gaweł,et al.  Amyotrophic lateral sclerosis: correlation of clinical and MR imaging findings. , 1995, Radiology.

[48]  J. Stears,et al.  Familial hypoplasia of both internal carotid arteries. , 1971, Archives of neurology.