Birefringence measurement of cornea and anterior segment by office-based polarization-sensitive optical coherence tomography.

We present a case series of cornea and anterior segment disorders investigated by an office-based polarization-sensitive optical coherence tomography (PS-OCT). Blebs of glaucoma patients treated by trabeculectomy, and corneas of keratoconus and keratoplasty patients were measured by PS-OCT. Birefringence formations in trabeculectomy bleb were measured in 1 control eye and 3 eyes of trabeculectomy model rabbits. Polarization insensitive scattering OCT and the depth-resolved birefringence were measured simultaneously by PS-OCT. Abnormal birefringence was observed in keratoconus cases with advanced thinning and with a rupture of Descemet’s membrane. The graft-host interface of the keratoplasty case showed abnormal birefringence. The appearance of abnormal birefringence in the cornea was likely to be an indication of cross-linking of collagen fibrils. The measurement of rabbit showed abnormal birefringence in the scarring eyes. Wide regions of strong birefringence were observed in the eyes of trabeculectomy patients who had high intraocular pressure. Visualization of scarring in bleb by PS-OCT may be useful for the planning of secondary surgery. PS-OCT showed promising for the study and diagnosis diseases related to abnormal fibrous tissues of the cornea and anterior eye segment.

[1]  F. Vargas-Martin,et al.  Measurements of the corneal birefringence with a liquid-crystal imaging polariscope. , 2002, Applied optics.

[2]  Félix Fanjul-Vélez,et al.  Polarimetric analysis of the human cornea measured by polarization-sensitive optical coherence tomography. , 2010, Journal of biomedical optics.

[3]  E A Swanson,et al.  Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography. , 1994, Archives of ophthalmology.

[4]  Y. Yasuno,et al.  Polarization-sensitive swept-source optical coherence tomography with continuous source polarization modulation. , 2008, Optics express.

[5]  Adrian Gh. Podoleanu,et al.  Combinations of techniques in imaging the retina with high resolution , 2008, Progress in Retinal and Eye Research.

[6]  Barry Cense,et al.  Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography. , 2004, Investigative ophthalmology & visual science.

[7]  A. Stanworth.  Polarized Light Studies of the Cornea , 1953 .

[8]  Shuichi Makita,et al.  Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography , 2010, BiOS.

[9]  U. Schmidt-Erfurth,et al.  Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography. , 2008, Optics express.

[10]  Shuichi Makita,et al.  Full-range polarization-sensitive swept-source optical coherence tomography by simultaneous transversal and spectral modulation. , 2010, Optics express.

[11]  U. Schmidt-Erfurth,et al.  Human macula investigated in vivo with polarization-sensitive optical coherence tomography. , 2006, Investigative ophthalmology & visual science.

[12]  Christian Ahlers,et al.  Performance of automated drusen detection by polarization-sensitive optical coherence tomography. , 2011, Investigative ophthalmology & visual science.

[13]  Michael Pircher,et al.  Imaging of birefringent properties of keratoconus corneas by polarization-sensitive optical coherence tomography. , 2007, Investigative ophthalmology & visual science.

[14]  Michael Pircher,et al.  Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography. , 2004, Journal of biomedical optics.

[15]  H. Kasprzak,et al.  Linear birefringence measurements of the in vitro human cornea , 2003, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[16]  Michael Pircher,et al.  Single camera based spectral domain polarization sensitive optical coherence tomography. , 2007, Optics express.

[17]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991 .

[18]  T. Milner,et al.  Review of polarization sensitive optical coherence tomography and Stokes vector determination. , 2002, Journal of biomedical optics.

[19]  G. V. van Blokland,et al.  Corneal polarization in the living human eye explained with a biaxial model. , 1987, Journal of the Optical Society of America. A, Optics and image science.

[20]  Yoshiaki Yasuno,et al.  Investigation of post-glaucoma-surgery structures by three-dimensional and polarization sensitive anterior eye segment optical coherence tomography. , 2009, Optics express.

[21]  Toyohiko Yatagai,et al.  Imaging polarimetry in age-related macular degeneration. , 2008, Investigative ophthalmology & visual science.

[22]  Yoshiaki Yasuno,et al.  Evaluation of trabeculectomy blebs using 3-dimensional cornea and anterior segment optical coherence tomography. , 2009, Ophthalmology.

[23]  A. Stanworth,et al.  Polarized Light Studies Of The Cornea: I. The Isolated Cornea , 1953 .

[24]  Qiang Wu,et al.  Evaluating subconjunctival bleb function after trabeculectomy using slit-lamp optical coherence tomography and ultrasound biomicroscopy. , 2008, Chinese medical journal.

[25]  Shuichi Makita,et al.  Generalized Jones matrix optical coherence tomography: performance and local birefringence imaging. , 2010, Optics express.

[26]  Toyohiko Yatagai,et al.  Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry. , 2008, Journal of biomedical optics.

[27]  C. Baudouin,et al.  In vivo confocal microscopy study of blebs after filtering surgery. , 2005, Ophthalmology.

[28]  Toyohiko Yatagai,et al.  Three-dimensional Anterior Segment Optical Coherence Tomography of Filtering Blebs After Trabeculectomy , 2008, Journal of glaucoma.

[29]  R. Bone,et al.  Optical anisotropy of the human cornea determined with a polarizing microscope. , 2007, Applied optics.

[30]  Tin Aung,et al.  Imaging of trabeculectomy blebs using anterior segment optical coherence tomography. , 2007, Ophthalmology.