Fitting Problems: Evaluating Model Fit in Behavior Genetic Models

In behavior genetics, like many fields, researchers must decide whether their models adequately explain their data – whether their models “fit” at some satisfactory level. Well-fitting models are compelling, whereas poorly-fitting models are not (Rodgers & Rowe, 2002). Oftentimes, researchers evaluate model fit by employing “universal” rules of thumb (e.g., Hu and Bentler, 1999). However, these rules are not universal, and should be treated as model specific (Kang et al., 2016). Accordingly, we focused on developing fit criteria emulating Hu and Bentler (1999) for classic univariate models (ACE; CE; AE) by fitting simulated twin data with correctly- and incorrectly-specified models. Ideal criteria should consistently accept correct models and reject incorrect models. Classic ACE models were indistinguishable and virtually all fit indices were non-informative because (or especially when) they were obtained in saturated models. For non-ACE models, criteria were informative. Nevertheless, every fit metric employed, except TLI, differed markedly across models and/or conditions. Universal solutions remain elusive, but promising and valid approaches include nested model comparisons, increasing degrees of freedom, and ruthless skepticism.

[1]  R. Plomin,et al.  Publication Trends Over 55 Years of Behavioral Genetic Research , 2016, Behavior Genetics.

[2]  H. Whitehead,et al.  Cultural Hitchhiking in the Matrilineal Whales , 2017, Behavior genetics.

[3]  J. S. Long,et al.  Testing Structural Equation Models , 1993 .

[4]  Michael C. Frank,et al.  Estimating the reproducibility of psychological science , 2015, Science.

[5]  T. Mackay,et al.  Genetic and Genomic Response to Selection for Food Consumption in Drosophila melanogaster , 2016, Behavior Genetics.

[6]  Michael C. Neale,et al.  Methodology for Genetic Studies of Twins and Families , 1992 .

[7]  Gregory R. Hancock,et al.  The Reliability Paradox in Assessing Structural Relations Within Covariance Structure Models , 2011 .

[8]  Evan Mayo-Wilson,et al.  Journal article reporting standards for quantitative research in psychology: The APA Publications and Communications Board task force report. , 2018, The American psychologist.

[9]  N. Pedersen,et al.  Associations Between Fetal Growth and Self-Perceived Health Throughout Adulthood: A Co-twin Control Study , 2016, Behavior genetics.

[10]  J. Rodgers The epistemology of mathematical and statistical modeling: a quiet methodological revolution. , 2010, The American psychologist.

[11]  Jennifer R. Harris,et al.  Heritability of adult body height: a comparative study of twin cohorts in eight countries. , 2003, Twin research : the official journal of the International Society for Twin Studies.

[12]  J. Ioannidis Why Most Published Research Findings Are False , 2019, CHANCE.

[13]  Robert Plomin,et al.  Top 10 Replicated Findings From Behavioral Genetics , 2016, Perspectives on psychological science : a journal of the Association for Psychological Science.

[14]  E. Turkheimer,et al.  Nonshared environment: a theoretical, methodological, and quantitative review. , 2000, Psychological bulletin.

[15]  S. Ponsuksili,et al.  Adrenocortical Expression Profiling of Cattle with Distinct Juvenile Temperament Types , 2016, Behavior Genetics.

[16]  K. Clark,et al.  Forward Genetic Screening Using Behavioral Tests in Zebrafish: A Proof of Concept Analysis of Mutants , 2017, Behavior genetics.

[17]  H. Siemens Die Zwillingspathologie: Ihre Bedeutung · Ihre Methodik · Ihre Bisherigen Ergebnisse , 1924 .

[18]  H. Marsh,et al.  In Search of Golden Rules: Comment on Hypothesis-Testing Approaches to Setting Cutoff Values for Fit Indexes and Dangers in Overgeneralizing Hu and Bentler's (1999) Findings , 2004 .

[19]  Timothy R. Brick,et al.  OpenMx 2.0: Extended Structural Equation and Statistical Modeling , 2015, Psychometrika.