The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death

[1]  Z. Mao,et al.  Phosphorylation of ATM by Cdk5 mediates DNA damage signaling and regulates neuronal death , 2009, Nature Cell Biology.

[2]  P. L. Peng,et al.  Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity , 2008, Neuron.

[3]  M. Kelley,et al.  Implications of apurinic/apyrimidinic endonuclease in reactive oxygen signaling response after cisplatin treatment of dorsal root ganglion neurons. , 2008, Cancer research.

[4]  K. Shah,et al.  Novel genetic tools reveal Cdk5's major role in Golgi fragmentation in Alzheimer's disease. , 2008, Molecular biology of the cell.

[5]  Avanti Kulkarni,et al.  The involvement of DNA-damage and -repair defects in neurological dysfunction. , 2008, American journal of human genetics.

[6]  David S. Park,et al.  Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP , 2008, Proceedings of the National Academy of Sciences.

[7]  David S. Park,et al.  Required Roles of Bax and JNKs in Central and Peripheral Nervous System Death of Retinoblastoma-deficient Mice* , 2008, Journal of Biological Chemistry.

[8]  Y. Seo,et al.  Base excision DNA repair defect in Gadd45a-deficient cells , 2007, Oncogene.

[9]  B. Demple,et al.  ATF4-Dependent Oxidative Induction of the DNA Repair Enzyme Ape1 Counteracts Arsenite Cytotoxicity and Suppresses Arsenite-Mediated Mutagenesis , 2007, Molecular and Cellular Biology.

[10]  David S. Park,et al.  Role of Cdk5-Mediated Phosphorylation of Prx2 in MPTP Toxicity and Parkinson's Disease , 2007, Neuron.

[11]  S. Humbert,et al.  Phosphorylation of Huntingtin by Cyclin-Dependent Kinase 5 Is Induced by DNA Damage and Regulates Wild-Type and Mutant Huntingtin Toxicity in Neurons , 2007, The Journal of Neuroscience.

[12]  Kyong-Tai Kim,et al.  Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death , 2007, Journal of Cell Science.

[13]  G. Tell,et al.  Altered intracellular redox status in Gaucher disease fibroblasts and impairment of adaptive response against oxidative stress , 2007, Journal of cellular physiology.

[14]  M. Kelley,et al.  The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target. , 2007, Molecular aspects of medicine.

[15]  K. S. Rao Mechanisms of Disease: DNA repair defects and neurological disease , 2007, Nature Clinical Practice Neurology.

[16]  J. Rudolph Inhibiting transient protein–protein interactions: lessons from the Cdc25 protein tyrosine phosphatases , 2007, Nature Reviews Cancer.

[17]  David S. Park,et al.  The Chk1/Cdc25A Pathway as Activators of the Cell Cycle in Neuronal Death Induced by Camptothecin , 2006, The Journal of Neuroscience.

[18]  David S. Park,et al.  Calpain-Regulated p35/cdk5 Plays a Central Role in Dopaminergic Neuron Death through Modulation of the Transcription Factor Myocyte Enhancer Factor 2 , 2006, The Journal of Neuroscience.

[19]  M. Sternberg,et al.  Isolation of a small molecule inhibitor of DNA base excision repair , 2005, Nucleic acids research.

[20]  David S. Park,et al.  Cyclin-Dependent Kinase 5 Mediates Neurotoxin-Induced Degradation of the Transcription Factor Myocyte Enhancer Factor 2 , 2005, The Journal of Neuroscience.

[21]  David S. Park,et al.  Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[22]  M. Kelley,et al.  The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress. , 2005, DNA repair.

[23]  G. Tell,et al.  The intracellular localization of APE1/Ref-1: more than a passive phenomenon? , 2005, Antioxidants & redox signaling.

[24]  B. Demple,et al.  A vital role for Ape1/Ref1 protein in repairing spontaneous DNA damage in human cells. , 2005, Molecular cell.

[25]  David S. Park,et al.  BAG5 Inhibits Parkin and Enhances Dopaminergic Neuron Degeneration , 2004, Neuron.

[26]  Li-Huei Tsai,et al.  Cdk5 deregulation in the pathogenesis of Alzheimer's disease. , 2004, Trends in molecular medicine.

[27]  Dustin J Maly,et al.  A mechanism-based cross-linker for the identification of kinase-substrate pairs. , 2004, Journal of the American Chemical Society.

[28]  David S. Park,et al.  Nuclear Factor-κB Modulates the p53 Response in Neurons Exposed to DNA Damage , 2004, The Journal of Neuroscience.

[29]  Li-Huei Tsai,et al.  Cdk5, a therapeutic target for Alzheimer's disease? , 2004, Biochimica et biophysica acta.

[30]  R. DePinho,et al.  Decreased Cyclin-Dependent Kinase 5 (cdk5) Activity Is Accompanied by Redistribution of cdk5 and Cytoskeletal Proteins and Increased Cytoskeletal Protein Phosphorylation in p35 Null Mice , 2003, The Journal of Neuroscience.

[31]  David S. Park,et al.  Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[32]  David S. Park,et al.  Calpains Mediate p53 Activation and Neuronal Death Evoked by DNA Damage* , 2003, Journal of Biological Chemistry.

[33]  David S. Park,et al.  Inhibition of Calpains Prevents Neuronal and Behavioral Deficits in an MPTP Mouse Model of Parkinson's Disease , 2003, The Journal of Neuroscience.

[34]  Junmin Peng,et al.  Cdk5-Mediated Inhibition of the Protective Effects of Transcription Factor MEF2 in Neurotoxicity-Induced Apoptosis , 2003, Neuron.

[35]  J. Lieberman,et al.  Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A , 2003, Nature Immunology.

[36]  S. Boiteux,et al.  Endogenous DNA abasic sites cause cell death in the absence of Apn1, Apn2 and Rad1/Rad10 in Saccharomyces cerevisiae , 2002, EMBO Journal.

[37]  Rong Li,et al.  The Protein SET Binds the Neuronal Cdk5 Activator p35 nck5a and Modulates Cdk5/p35 nck5a Activity* , 2002, The Journal of Biological Chemistry.

[38]  David S. Park,et al.  c-Jun mediates axotomy-induced dopamine neuron death in vivo , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[39]  David S. Park,et al.  APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death , 2001, The Journal of cell biology.

[40]  L. Tsai,et al.  Cdk5 on the brain. , 2001, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[41]  T. Ulbright,et al.  Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation. , 2001, Cancer research.

[42]  M. Kelley,et al.  Going APE over ref-1. , 2000, Mutation research.

[43]  L. Tsai,et al.  Neurotoxicity induces cleavage of p35 to p25 by calpain , 2000, Nature.

[44]  Samuel H. Wilson,et al.  Protection against Methylation-induced Cytotoxicity by DNA Polymerase β-Dependent Long Patch Base Excision Repair* , 2000, The Journal of Biological Chemistry.

[45]  L. Tsai,et al.  Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration , 1999, Nature.

[46]  L. Chimelli,et al.  Microwave-stimulated recovery of myosin-V immunoreactivity from formalin-fixed, paraffin-embedded human CNS , 1999, Journal of Neuroscience Methods.

[47]  P. Upton,et al.  Highly sensitive apurinic/apyrimidinic site assay can detect spontaneous and chemically induced depurination under physiological conditions. , 1998, Cancer research.

[48]  J. Kimura,et al.  p35nck5a and cyclin-dependent kinase 5 colocalize in Lewy bodies of brains with Parkinson’s disease , 1997, Acta Neuropathologica.

[49]  P. Schwartzkroin,et al.  Evidence for p53-Mediated Modulation of Neuronal Viability , 1996, The Journal of Neuroscience.

[50]  Richard J Smeyne,et al.  The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[51]  L. Tsai,et al.  A family of human cdc2‐related protein kinases. , 1992, The EMBO journal.

[52]  J. H. Wang,et al.  Purification and characterization of a novel proline-directed protein kinase from bovine brain. , 1992, The Journal of biological chemistry.

[53]  E. Koutsilieri,et al.  MPP+ selectively affects calcium homeostasis in mesencephalic cell cultures from embryonal C57/B16 mice , 2005, Journal of Neural Transmission / General Section JNT.

[54]  K. Kinzler,et al.  A simplified system for generating recombinant adenoviruses. , 1998, Proceedings of the National Academy of Sciences of the United States of America.