Determination of the Optimum temperature for regional renal hypothermia during temporary renal ischaemia.

To determine the optimum temperature at which the in situ kidney should be maintained while it is ischaemic, 47 mongrel dogs were studied. 35 of these underwent 90 minutes of left renal ischaemia with the kidney temperature maintained at 37 degree, 30 degree, 22 degree, 15 degree and 0 degree C respectively. The effect on renal function was determined by measurements of G.F.R. before and at regular 15-minute intervals after the inschaemic period. Computer statistical analysis exposed the optimum temperature to be 15 degree C. Renal artery blood flow, renal histology, 15-Cr labelled platelets and renal arteriography were used to determine the mechanism of ischaemic injury. Quantitation of renal cell injury confirmed that no additional protection to ischaemia could be gained by colling below 15 degree C. 15 degree C is recommended as the optimum temperature for use in clinical renal hypothermia.

[1]  J. Krog,et al.  Renal circulatory occlusion and local cooling. , 1959, Journal of applied physiology.

[2]  J. Wickham,et al.  Hypothermia in the conservative surgery of renal disease. , 2008, British journal of urology.

[3]  F. Belzer,et al.  Etiology of Rising Perfusion Pressure in Isolated Organ Perfusion , 1968, Annals of surgery.

[4]  J. Wickham,et al.  Regional renal hypothermia. , 1967, London Clinic medical journal.

[5]  J. Connolly,et al.  AN EXPERIMENTAL STUDY OF SELECTIVE RENAL HYPOTHERMIA. , 1963, American journal of surgery.

[6]  J. Wickham,et al.  Renal hypothermia in complicated nephrolithotomy. , 1968, The Journal of urology.

[7]  J. Coe,et al.  Canine renal autografts. Studies of reversible histopathologic changes following prolonged extracorporeal refrigeration. , 1961, Archives of surgery.

[8]  Bogardus Gm,et al.  The influence of temperature upon ischemic renal damage. , 1956 .

[9]  C. F. Anderson,et al.  Iothalamate sodium I 125 vs cyanocobalamin Co 57 as a measure of glomerular filtration rate in man. , 1968, JAMA.

[10]  D. Albert,et al.  REGIONAL HYPOTHERMIA IN ACUTE RENAL ISCHAEMIA: A RE‐EVALUATION OF THE OPTIMAL RENAL TEMPERATURE , 1970 .

[11]  G. Szász A Kinetic Photometric Method for Serum γ-Glutamyl Transpeptidase , 1969 .

[12]  C. Smythe,et al.  Renal Hypothermia**Supported by the University of Toronto Kidney Research Fund. , 1960 .

[13]  Cockett At,et al.  The kidney and regional hypothermia. , 1961 .

[14]  G. Glenner,et al.  HISTOCHEMICAL DEMONSTRATION OF A GAMMA-GLUTAMYL TRANSPEPTIDASE-LIKE ACTIVITY , 1962 .

[15]  M. Metzner Simplified renal hypothermia as adjunct to conservative renal surgery. , 1972, British journal of urology.

[16]  R. M. Mitchell Renal cooling and ischemia , 1959, The British journal of surgery.

[17]  F. T. Graves Renal hypothermia: An aid to partial nephrectomy , 1963 .

[18]  G. S. Wilson Clinical experience in renal hypothermia. , 1963, The Journal of urology.

[19]  H. H. Stewart THE SURGERY OF THE KIDNEY IN THE TREATMENT OF RENAL STONE1 , 1960 .