Management of radiation-induced plantar hyperkeratosis with DuoDERM hydrocolloid occlusion and shaving : a randomized controlled trial

A randomized trial was conducted to determined whether hydrocolloid occlusion plus shaving was superior to shaving alone on healing and relief of symptoms of radiation-induced plantar hyperkeratosis. A total of 30 consecutive patients took part in the study. During 12 weeks, six shavings were performed every 14 days in both groups. The patients were randomized to receive shaving alone or shaving with DuoDERM occlusion in addition. Outcome measures were the size of the hyperkeratosis, a patient-performed discomfort score, and a patient-performed overall judgement of the trial. The results demonstrated benefit of occlusion on the reduction in the size of the hyperkeratosis (P = 0.02) and decreased discomfort (P = 0.005). Complete remission of the hyperkeratosis was shown in 86% and 47% of the patients in the occlusion group and conventional group, respectively (P = 0.07). In the occlusion group, 71% of the patients were without symptoms compared with 33% in the conventional group (P = 0.09). Overall trial j...

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