Creation of a fully digital pathology slide archive by high-volume tissue slide scanning.

Digital slide scanners for scanning glass slides are becoming increasingly popular because current scanners are fast enough and produce good enough images for diagnostic purposes, education, and research. Also, the price for storing vast amounts of data has decreased over the last years, and this trend is expected to continue. Where most laboratories use their scanners mainly for education and research with limited financial and technical implications, we decided to face the huge challenges of prospectively setting up a fully digital pathology slide archive, primarily aiming to optimize the preparation and running of clinicopathological conferences. In this article, we describe the setup of our digital archiving solution and discuss the technical challenges we had to overcome. To give insight in the performance of our digital archive, we provide some statistics as well. We also present our thoughts on future developments in the area of digital slide scanning.

[1]  William M. Gallagher,et al.  Creation of a digital slide and tissue microarray resource from a multi-institutional predictive toxicology study in the rat: an initial report from the PredTox group. , 2008, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

[2]  K. Kayser,et al.  Recent Developments and Present Status of Telepathology , 2000, Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology.

[3]  M. Langer,et al.  Integrating HIS–RIS–PACS: the Freiburg experience , 1998, European Radiology.

[4]  G.E. Moore,et al.  Cramming More Components Onto Integrated Circuits , 1998, Proceedings of the IEEE.

[5]  Peter Hufnagl,et al.  Integration and acceleration of virtual microscopy as the key to successful implementation into the routine diagnostic process , 2009, Diagnostic pathology.

[6]  Marcial García Rojo,et al.  Reading virtual slide using web viewers: results of subjective experience with three different solutions , 2008, Diagnostic pathology.

[7]  Peter Hufnagl,et al.  Image standards in Tissue-Based Diagnosis (Diagnostic Surgical Pathology) , 2008, Diagnostic pathology.

[8]  Jimmie Stewart,et al.  Virtual microscopy for cytology proficiency testing: Are we there yet? , 2007, Cancer.

[9]  Christel Daniel-Le Bozec,et al.  Refining DICOM for Pathology - Progress from the IHE and DICOM Pathology working groups , 2007, MedInfo.

[10]  M. Valkenburg,et al.  Traditionele versus virtuele microscopie bij het onderwijs in de histopathologie , 2009 .

[11]  J A Beliën,et al.  Counting mitoses by image processing in Feulgen stained breast cancer sections: the influence of resolution. , 1997, Cytometry.

[12]  Mark W. Braun,et al.  Improved learning efficiency and increased student collaboration through use of virtual microscopy in the teaching of human pathology , 2008, Anatomical sciences education.

[13]  Laoighse Mulrane,et al.  Automated image analysis in histopathology: a valuable tool in medical diagnostics , 2008, Expert review of molecular diagnostics.

[14]  Andriani Daskalaki,et al.  Handbook of Research on Systems Biology Applications in Medicine , 2008 .

[15]  R S Weinstein,et al.  Prospects for telepathology. , 1986, Human pathology.

[16]  Ross Foley,et al.  Automated Image Analysis Approaches in Histopathology , 2009 .

[17]  J. Woosley,et al.  Randomized comparison of virtual microscopy and traditional glass microscopy in diagnostic accuracy among dermatology and pathology residents. , 2009, Human pathology.

[18]  M Lundin,et al.  A digital atlas of breast histopathology: an application of web based virtual microscopy , 2004, Journal of Clinical Pathology.

[19]  Jorma Isola,et al.  The Application of JPEG2000 in Virtual Microscopy , 2009, Journal of Digital Imaging.

[20]  Sean SP Costello,et al.  Development and Evaluation of the Virtual Pathology Slide: A New Tool in Telepathology , 2003, Journal of medical Internet research.

[21]  G. A. Meijer,et al.  Experience with a Dynamic Inexpensive Video-Conferencing System for Frozen Section Telepathology , 2000, Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology.

[22]  Hans Beck,et al.  A European network for virtual microscopy—design, implementation and evaluation of performance , 2009, Virchows Archiv.

[23]  H. Tanke,et al.  Supervised automated microscopy increases sensitivity and efficiency of detection of sentinel node micrometastases in patients with breast cancer , 2004, Journal of Clinical Pathology.