Environmental stress in primary depressive illness.

The occurrence of life-change events (as defined by the social readjustment rating questionnaire) prior to disease onset was measured in a group of 74 patients suffering from primary depressive disorders. The resultant frequency distribution histogram was unimodal. Patients with a positive family history for depression did not differ significantly, in these measurements, from those with a negative family history nor did patients with "endogenous" depression differ significantly from those with "reactive" depression. We were, therefore, unable to distinguish two populations within the depressed group using this parameter. We conclude that the terms "endogenous" and "reactive" are misleading for the majority of patients with depressive illness.

[1]  H. Hendrie,et al.  Stress, immunoglobulin levels and early polyarthritis. , 1971, Journal of psychosomatic research.

[2]  R. Kendell,et al.  The clinical distinction between psychotic and neurotic depressions. , 1970, The British journal of psychiatry : the journal of mental science.

[3]  H. Eysenck.  The Classification of Depressive Illnesses , 1970, British Journal of Psychiatry.

[4]  R. Kendell.  The Classification of Depressive Illnesses , 1970, British Journal of Psychiatry.

[5]  W. Bunney,et al.  Environmental factors preceding the onset of severe depressions. , 1970, Psychiatry.

[6]  G. Klerman,et al.  Life Events and Depression: A Controlled Study , 1969 .

[7]  J. Roy,et al.  Endogenous and Neurotic Syndromes of Depression: A Factor Analytic Study of 104 Cases. Clinical Features , 1969, British Journal of Psychiatry.

[8]  R. Rahe,et al.  Life-change patterns surrounding illness experience. , 1968, Journal of psychosomatic research.

[9]  T. H. Holmes,et al.  The Social Readjustment Rating Scale. , 1967, Journal of psychosomatic research.

[10]  B. Murphy,et al.  The Independence of Neurotic and Endogenous Depression , 1967, British Journal of Psychiatry.

[11]  M. G. Sandifer,et al.  The two-type thesis of depressive disorders. , 1966, The American journal of psychiatry.

[12]  G. Winokur,et al.  Family history studies. I. Two types of affective disorders separated according to genetic and clinical factors. , 1966, Recent advances in biological psychiatry.

[13]  L. Kiloh,et al.  The Independence of Neurotic Depression and Endogenous Depression , 1963, British Journal of Psychiatry.

[14]  J. T. Rose.  Reactive and Endogenous Depressions—Response to E.C.T. , 1963, British Journal of Psychiatry.

[15]  H. Geiger,et al.  The epidemiology of rheumatoid arthritis. A review with special attention to social factors. , 1962, Journal of chronic diseases.

[16]  M. Hamilton,et al.  Clinical syndromes in depressive states. , 1959, The Journal of mental science.