Efficacy of intrathecal neostigmine for the relief of postinguinal herniorrhaphy pain

Background: Intrathecal administration of various doses of neostigmine has been reported to produce analgesia without neurotoxicity in both animal and human studies. The present study was undertaken to evaluate the efficacy and safety of intrathecal neostigmine for the relief of pain for patients having undergone inguinal herniorrhaphy surgery.

[1]  S. Liu,et al.  Dose-response effects of spinal neostigmine added to bupivacaine spinal anesthesia in volunteers. , 1999, Anesthesiology.

[2]  H. Park,et al.  The efficacy of intrathecal neostigmine, intrathecal morphine, and their combination for post-cesarean section analgesia. , 1998, Anesthesia and analgesia.

[3]  G. Lauretti,et al.  Intrathecal neostigmine for postoperative analgesia after orthopedic surgery. , 1997, Journal of clinical anesthesia.

[4]  J. Eisenach,et al.  Studies on the Safety of Glucose and Paraben-Containing Neostigmine for Intrathecal Administration , 1997, Anesthesia and analgesia.

[5]  J. Eisenach,et al.  Intrathecal neostigmine for post-cesarean section analgesia: dose response. , 1997, Anesthesia and analgesia.

[6]  G. Lauretti,et al.  Dose-Response Study of Intrathecal Morphine Versus Intrathecal Neostigmine, Their Combination, or Placebo for Postoperative Analgesia in Patients Undergoing Anterior and Posterior Vaginoplasty , 1996, Anesthesia and analgesia.

[7]  J. Eisenach,et al.  Cerebrospinal Fluid Norepinephrine and Acetylcholine Concentrations During Acute Pain , 1996, Anesthesia and analgesia.

[8]  G. Lauretti,et al.  Intrathecal Neostigmine for Postoperative Analgesia: dose Response , 1996, Regional Anesthesia & Pain Medicine.

[9]  S. Laurent,et al.  The use of the McCoy laryngoscope in patients with simulated cervical spine injuries , 1996, Anaesthesia.

[10]  J. Eisenach,et al.  Postoperative Analgesia from Intrathecal Neostigmine in Sheep , 1995, Anesthesia and analgesia.

[11]  J. Eisenach,et al.  Phase I Safety Assessment of Intrathecal Neostigmine Methylsulfate in Humans , 1995, Anesthesiology.

[12]  M. Grafe,et al.  Studies on the Safety of Chronically Administered Intrathecal Neostigmine Methylsulfate in Rats and Dogs , 1995, Anesthesiology.

[13]  T. Yaksh,et al.  Cardiorespiratory and Spinal Cord Blood Flow Effects of Intrathecal Neostigmine Methylsulfate, Clonidine, and Their Combination in Sheep , 1995, Anesthesiology.

[14]  T. Yaksh,et al.  Antinociceptive Effects of Spinal Cholinesterase Inhibition and Isobolographic Analysis of the Interaction with μ and α2 Receptor Systems , 1994 .

[15]  M. Zhuo,et al.  Tonic cholinergic inhibition of spinal mechanical transmission , 1991, Pain.

[16]  Z. Henderson,et al.  Further evidence for the absence of a descending cholinergic projection from the brainstem to the spinal cord in the rat , 1991, Neuroscience Letters.

[17]  A. Ribeiro-da-Silva,et al.  Choline acetyltransferase‐immunoreactive profiles are presynaptic to primary sensory fibers in the rat superficial dorsal horn , 1990, The Journal of comparative neurology.

[18]  S. Iversen,et al.  Topography of choline acetyltransferase Immunoreactive Neurons and fibers in the rat spinal cord , 1986, Brain Research.

[19]  R. Dirksen,et al.  Antinociceptive effects of intrathecally injected cholinomimetic drugs in the rat and cat. , 1985, European journal of pharmacology.

[20]  J. E. Vaughn,et al.  The morphology and distribution of neurons containing choline acetyltransferase in the adult rat spinal cord: An immunocytochemical study , 1984, The Journal of comparative neurology.

[21]  R. Elde,et al.  Receptor autoradiography in thoracic spinal cord: correlation of neurotransmitter binding sites with sympathoadrenal neurons , 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[22]  W. Young,et al.  Autoradiographic localization of muscarinic cholinergic receptors in rat brainstem , 1981, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[23]  T. Yaksh,et al.  Antinociceptive effects of spinal cholinesterase inhibition and isobolographic analysis of the interaction with mu and alpha 2 receptor systems. , 1994, Anesthesiology.