Impact of Pregnancy‐Associated Plasma Protein‐A Deletion on the Adult Murine Skeleton

Introduction: The metalloproteinase, pregnancy‐associated plasma protein‐A (PAPP‐A) functions to enhance local insulin‐like growth factor (IGF)‐I bioavailability through cleavage of inhibitory IGF binding proteins. Because IGF‐I is an important regulator of skeletal growth and remodeling and PAPP‐A is highly expressed by osteoblastic cells, we hypothesized that, in the absence of PAPP‐A, bone physiology would be compromised because of a blunting of local IGF‐I action even in the presence of normal circulating IGF‐I levels.

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