Absorption distribution of an optical beam focused into a turbid medium.

The focusing of light into a turbid medium was studied with Monte Carlo simulations. Focusing was found to have a significant effect on the absorption distribution in turbid media when the depth of the focal point (the distance between the focal point and the surface of the turbid media) was less than or comparable with the transport mean free path. Focusing could significantly increase the peak absorption and narrow the absorption distribution. As the depth of the focal point increased, the peak absorption decreased, and the depth of peak absorption increased initially but quickly reached a plateau that was less than the transport mean free path. A refractive-index-mismatched boundary between the ambient medium and the turbid medium deteriorated the focusing effect, increased the absorption near the boundary, lowered the peak absorption, and broadened the absorption distribution.

[1]  B. Wilson,et al.  Monte Carlo modeling of light propagation in highly scattering tissues. I. Model predictions and comparison with diffusion theory , 1989, IEEE Transactions on Biomedical Engineering.

[2]  Amit Singh,et al.  Confocal microscopy: a powerful technique for biological research , 1998 .

[3]  S Andersson-Engels,et al.  Mathematical modelling of dynamic cooling and pre-heating, used to increase the depth of selective damage to blood vessels in laser treatment of port wine stains , 1996, Physics in medicine and biology.

[4]  S. A. Prahl,et al.  A Monte Carlo model of light propagation in tissue , 1989, Other Conferences.

[5]  M. Schweiger,et al.  Theoretical and experimental investigation of near-infrared light propagation in a model of the adult head. , 1997, Applied optics.

[6]  R. Alcouffe,et al.  Comparison of finite-difference transport and diffusion calculations for photon migration in homogeneous and heterogeneous tissues. , 1998, Physics in medicine and biology.

[7]  A Ismaelli,et al.  Monte carlo procedure for investigating light propagation and imaging of highly scattering media. , 1998, Applied optics.

[8]  B. Wilson,et al.  A Monte Carlo model for the absorption and flux distributions of light in tissue. , 1983, Medical physics.

[9]  S R Arridge,et al.  The finite-element method for the propagation of light in scattering media: frequency domain case. , 1997, Medical physics.

[10]  S L Jacques,et al.  CONV--convolution for responses to a finite diameter photon beam incident on multi-layered tissues. , 1997, Computer methods and programs in biomedicine.

[11]  Ashleyj . Welch,et al.  Optical-Thermal Response of Laser-Irradiated Tissue , 1995 .

[12]  L Wang,et al.  MCML--Monte Carlo modeling of light transport in multi-layered tissues. , 1995, Computer methods and programs in biomedicine.

[13]  Feld,et al.  Photon migration in turbid media using path integrals. , 1994, Physical review letters.

[14]  Weiss,et al.  Photon path-length distributions for transmission through optically turbid slabs. , 1993, Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics.

[15]  Lihong V. Wang,et al.  Monte Carlo Modeling of Light Transport in Tissues , 1995 .

[16]  I. Lux Monte Carlo Particle Transport Methods: Neutron and Photon Calculations , 1991 .

[17]  F. D. de Mul,et al.  Three-dimensional photoacoustic imaging of blood vessels in tissue. , 1998, Optics letters.