High-field imaging of neurodegenerative diseases.

High-field magnetic resonance (MR) imaging is showing potential for imaging of neurodegenerative diseases. 7 T MR imaging is beginning to be used in a clinical research setting and the theoretical benefits of higher signal-to-noise ratio, sensitivity to iron, improved MR angiography, and increased spectral resolution in spectroscopy are being confirmed. Despite the limited number of studies to date, initial results in patients with multiple sclerosis, Alzheimer disease, and Huntington disease show promising additional features in contrast that may help the diagnosis of these disorders.

[1]  Yu-Chung N. Cheng,et al.  Susceptibility weighted imaging (SWI) , 2004, Zeitschrift fur medizinische Physik.

[2]  Andrew G. Webb,et al.  Origin and reduction of motion and f0 artifacts in high resolution T2*-weighted magnetic resonance imaging: Application in Alzheimer's disease patients , 2010, NeuroImage.

[3]  Jaco J. M. Zwanenburg,et al.  Fluid attenuated inversion recovery (FLAIR) MRI at 7.0 Tesla: comparison with 1.5 and 3.0 Tesla , 2009, European Radiology.

[4]  M. Ferrari,et al.  Lenticulostriate Arterial Lumina Are Normal in Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy: A High-Field In Vivo MRI Study , 2010, Stroke.

[5]  Andrew G. Webb,et al.  Parallel transmit and receive technology in high-field magnetic resonance neuroimaging , 2010 .

[6]  Peter Boesiger,et al.  Slice‐selective FID acquisition, localized by outer volume suppression (FIDLOVS) for 1H‐MRSI of the human brain at 7 T with minimal signal loss , 2009, NMR in biomedicine.

[7]  Stéphane Lehéricy,et al.  Hippocampal sclerosis in temporal lobe epilepsy: findings at 7 T¹. , 2011, Radiology.

[8]  M. Ladd,et al.  Imaging of patients with hippocampal sclerosis at 7 Tesla: initial results. , 2010, Academic radiology.

[9]  Mandy M. A. Conijn,et al.  Cerebral Microbleeds on MR Imaging: Comparison between 1.5 and 7T , 2011, American Journal of Neuroradiology.

[10]  J. Schenck,et al.  An efficient, highly homogeneous radiofrequency coil for whole-body NMR imaging at 1.5 T , 1985 .

[11]  Zang-Hee Cho,et al.  Imaging and analysis of lenticulostriate arteries using 7.0‐Tesla magnetic resonance angiography , 2009, Magnetic resonance in medicine.

[12]  M. van Buchem,et al.  Improvements in high‐field localized MRS of the medial temporal lobe in humans using new deformable high‐dielectric materials , 2011, NMR in biomedicine.

[13]  M. Fukunaga,et al.  Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast , 2010, Proceedings of the National Academy of Sciences.

[14]  Yulin Ge,et al.  Seven-Tesla magnetic resonance imaging: new vision of microvascular abnormalities in multiple sclerosis. , 2008, Archives of neurology.

[15]  M. P. van den Heuvel,et al.  No evidence of microbleeds in ALS patients at 7 Tesla MRI , 2010, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

[16]  Richard Bowtell,et al.  Whole-brain susceptibility mapping at high field: A comparison of multiple- and single-orientation methods , 2010, NeuroImage.

[17]  S. Nelson,et al.  Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to iron , 2008, Annals of neurology.

[18]  Mike P. Wattjes,et al.  Lesion detection at seven Tesla in multiple sclerosis using magnetisation prepared 3D-FLAIR and 3D-DIR , 2011, European Radiology.

[19]  Nikos Evangelou,et al.  A Comparison of 3T and 7T in the Detection of Small Parenchymal Veins Within MS Lesions , 2009, Investigative radiology.

[20]  M. Schlamann,et al.  First Clinical Study on Ultra-High-Field MR Imaging in Patients with Multiple Sclerosis: Comparison of 1.5T and 7T , 2009, American Journal of Neuroradiology.

[21]  R. S. Hinks,et al.  Real‐time shimming to compensate for respiration‐induced B0 fluctuations , 2007, Magnetic resonance in medicine.

[22]  G. Kerchner,et al.  Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7-T MRI , 2010, Neurology.

[23]  Jullie W Pan,et al.  High frequency volume coils for clinical NMR imaging and spectroscopy , 1994, Magnetic resonance in medicine.

[24]  Peter R Luijten,et al.  Visualization of cerebral microbleeds with dual‐echo T2*‐weighted magnetic resonance imaging at 7.0 T , 2010, Journal of magnetic resonance imaging : JMRI.

[25]  Peter R Luijten,et al.  High‐resolution magnetization‐prepared 3D‐FLAIR imaging at 7.0 Tesla , 2010, Magnetic resonance in medicine.

[26]  K. Uğurbil,et al.  An Assessment of Current Brain Targets for Deep Brain Stimulation Surgery With Susceptibility-Weighted Imaging at 7 Tesla , 2010, Neurosurgery.

[27]  P S Morgan,et al.  Ultra-high-field imaging distinguishes MS lesions from asymptomatic white matter lesions , 2011, Neurology.

[28]  Chunlei Liu.  Susceptibility tensor imaging , 2010, Magnetic resonance in medicine.

[29]  D. Le Bihan,et al.  Intracortical Infarcts in Small Vessel Disease: A Combined 7-T Postmortem MRI and Neuropathological Case Study in Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy , 2011, Stroke.

[30]  K. Pruessmann,et al.  Spatiotemporal magnetic field monitoring for MR , 2008, Magnetic resonance in medicine.

[31]  Yi Wang,et al.  Quantitative susceptibility map reconstruction from MR phase data using bayesian regularization: Validation and application to brain imaging , 2010, Magnetic resonance in medicine.

[32]  Jeff H. Duyn,et al.  Extensive heterogeneity in white matter intensity in high-resolution T2 *-weighted MRI of the human brain at 7.0 T , 2006, NeuroImage.

[33]  Zang-Hee Cho,et al.  Non‐invasive visualization of basilar artery perforators with 7T MR angiography , 2010, Journal of magnetic resonance imaging : JMRI.

[34]  Max A. Viergever,et al.  MR venography of the human brain using susceptibility weighted imaging at very high field strength , 2008, Magnetic Resonance Materials in Physics, Biology and Medicine.

[35]  A. Lozano,et al.  Direct visualization of deep brain stimulation targets in Parkinson disease with the use of 7-tesla magnetic resonance imaging. , 2010, Journal of neurosurgery.

[36]  Jeroen van der Grond,et al.  Exploratory 7-Tesla magnetic resonance spectroscopy in Huntington’s disease provides in vivo evidence for impaired energy metabolism , 2011, Journal of Neurology.

[37]  N B Smith,et al.  New high dielectric constant materials for tailoring the B1+ distribution at high magnetic fields. , 2010, Journal of magnetic resonance.

[38]  Jody C Culham,et al.  Evaluation of preprocessing steps to compensate for magnetic field distortions due to body movements in BOLD fMRI. , 2010, Magnetic resonance imaging.

[39]  Jeroen van der Grond,et al.  Cerebral amyloidosis: postmortem detection with human 7.0-T MR imaging system. , 2009, Radiology.

[40]  Daniel B. Vigneron,et al.  Development of a robust method for generating 7.0 T multichannel phase images of the brain with application to normal volunteers and patients with neurological diseases , 2008, NeuroImage.

[41]  K. Uğurbil,et al.  In vivo 1H NMR spectroscopy of the human brain at high magnetic fields: Metabolite quantification at 4T vs. 7T , 2009, Magnetic resonance in medicine.

[42]  Rolf Gruetter,et al.  MR spectroscopy of the human brain with enhanced signal intensity at ultrashort echo times on a clinical platform at 3T and 7T , 2009, Magnetic resonance in medicine.

[43]  Oliver Kraff,et al.  7 tesla MRI of microbleeds and white matter lesions as seen in vascular dementia , 2011, Journal of magnetic resonance imaging : JMRI.

[44]  Pratik Mukherjee,et al.  High‐Resolution Phased‐Array MRI of the Human Brain at 7 Tesla: Initial Experience in Multiple Sclerosis Patients , 2010, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[45]  Matteo Pavan,et al.  Higher order reconstruction for MRI in the presence of spatiotemporal field perturbations , 2011, Magnetic resonance in medicine.

[46]  M. Fukunaga,et al.  Sensitivity of MRI resonance frequency to the orientation of brain tissue microstructure , 2010, Proceedings of the National Academy of Sciences.

[47]  Caterina Mainero,et al.  In vivo imaging of cortical pathology in multiple sclerosis using ultra-high field MRI , 2009, Neurology.

[48]  Ferdinand Schweser,et al.  Quantitative imaging of intrinsic magnetic tissue properties using MRI signal phase: An approach to in vivo brain iron metabolism? , 2011, NeuroImage.

[49]  G. Glover,et al.  Respiration‐induced B0 fluctuations and their spatial distribution in the human brain at 7 Tesla , 2002, Magnetic resonance in medicine.

[50]  Jullie W Pan,et al.  DEMONSTRATING THE PERIVASCULAR DISTRIBUTION OF MS LESIONS IN VIVO WITH 7-TESLA MRI , 2008, Neurology.

[51]  Jeff H. Duyn,et al.  Susceptibility contrast in high field MRI of human brain as a function of tissue iron content , 2009, NeuroImage.

[52]  Yukihiko Fujii,et al.  In Vivo Visualization of Senile‐Plaque‐Like Pathology in Alzheimer's Disease Patients by MR Microscopy on a 7T System , 2008, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[53]  Jeff H. Duyn,et al.  High-field MRI of brain cortical substructure based on signal phase , 2007, Proceedings of the National Academy of Sciences.

[54]  A. Anderson,et al.  Composite RF pulses for B1+-insensitive volume excitation at 7 Tesla. , 2010, Journal of magnetic resonance (San Diego, Calif. 1997 : Print).

[55]  Jeroen Hendrikse,et al.  MR angiography of the cerebral perforating arteries with magnetization prepared anatomical reference at 7T: Comparison with time‐of‐flight , 2008, Journal of magnetic resonance imaging : JMRI.