Dexamethasone suppression test in alcoholism

ABSTRACT– The hypothalamic‐pituitary‐adrenal function was investigated in alcoholic patients using the dexamethasone suppression test (DST). Seventy‐two patients were studied when they had been abstinent from alcohol for 3 to 6 weeks. Eight patients undergoing detoxification and 79 control subjects were investigated for comparison. Alcoholic patients after a 3‐ to 6‐week abstinence period showed significantly higher prevalence of abnormal DST results (28 %) than control subjects (11 %). Patients undergoing detoxification showed even a higher prevalence of abnormal DST results (62 %). Abnormal DST status was not associated with the presence of depression in these patients but was associated with abnormal liver function. It is supposed that abnormal DST responses in alcoholic patients are not diagnostic of depression but appear to be related to effects of alcohol either on liver metabolism or on the hypothalamic‐pituitary‐adrenal function or both.

[1]  A. Coppen,et al.  Dexamethasone Suppression Test in Depression and other Psychiatric Illness , 1983, British Journal of Psychiatry.

[2]  H. Kehlet,et al.  HYPOTHALAMIC–PITUITARY–ADRENOCORTICAL FUNCTION IN CHRONIC ALCOHOLISM , 1982, Clinical endocrinology.

[3]  V. James,et al.  RAPID COMMUNICATION: ABNORMAL SUPPRESSION OF PLASMA CORTISOL DURING THE INTRAVENOUS INFUSION OF DEXAMETHASONE TO ALCOHOLIC PATIENTS , 1981, Clinical endocrinology.

[4]  T Stockwell,et al.  The development of a questionnaire to measure severity of alcohol dependence. , 1979, The British journal of addiction to alcohol and other drugs.

[5]  G. Oxenkrug.  DEXAMETHASONE TEST IN ALCOHOLICS , 1978, The Lancet.

[6]  E. Robins,et al.  Research diagnostic criteria: rationale and reliability. , 1978, Archives of general psychiatry.

[7]  R. H. Wilkins.  The hidden alcoholic in general practice. , 1975, The British journal of addiction to alcohol and other drugs.

[8]  P. Stokes.  ADRENOCORTICAL ACTIVATION IN ALCOHOLICS DURING CHRONIC DRINKING * , 1973, Annals of the New York Academy of Sciences.

[9]  R. Cadoret,et al.  Depressive disease: a genetic study. , 1971, Archives of general psychiatry.

[10]  V. Marks,et al.  Plasma-hydrocortisone response to ethanol in chronic alcoholics. , 1969, Lancet.

[11]  J. Jenkins,et al.  Adrenocortical response to ethanol in man. , 1968, British medical journal.

[12]  E. Espiner.  Urinary cortisol excretion in stress situations and in patients with Cushing's syndrome. , 1966, The Journal of endocrinology.

[13]  A. Beck,et al.  An inventory for measuring depression. , 1961, Archives of general psychiatry.

[14]  B. Carroll,et al.  A specific laboratory test for the diagnosis of melancholia. Standardization, validation, and clinical utility. , 1981, Archives of general psychiatry.