Advances in revealing the molecular targets downstream of oxidative stress-induced proapoptotic kinase signaling in diabetic embryopathy.

[1]  S. Fang,et al.  Ask1 Gene Deletion Blocks Maternal Diabetes–Induced Endoplasmic Reticulum Stress in the Developing Embryo by Disrupting the Unfolded Protein Response Signalosome , 2014, Diabetes.

[2]  D. Wishart,et al.  Metabolomic prediction of fetal congenital heart defect in the first trimester. , 2014, American journal of obstetrics and gynecology.

[3]  D. Graves,et al.  FOXO Transcription Factors: Their Clinical Significance and Regulation , 2014, BioMed research international.

[4]  F. Wang,et al.  Superoxide dismutase 1 overexpression in mice abolishes maternal diabetes-induced endoplasmic reticulum stress in diabetic embryopathy. , 2013, American journal of obstetrics and gynecology.

[5]  G. MacLennan,et al.  Deregulation of FoxO3a accelerates prostate cancer progression in TRAMP mice , 2013, The Prostate.

[6]  F. Wang,et al.  Trehalose prevents neural tube defects by correcting maternal diabetes-suppressed autophagy and neurogenesis. , 2013, American journal of physiology. Endocrinology and metabolism.

[7]  M. Werler,et al.  The impact of folic acid intake on the association among diabetes mellitus, obesity, and spina bifida. , 2013, American journal of obstetrics and gynecology.

[8]  H. R. Zielke,et al.  Maternal Hyperglycemia Activates an ASK1–FoxO3a–Caspase 8 Pathway That Leads to Embryonic Neural Tube Defects , 2013, Science Signaling.

[9]  D. Wishart,et al.  Metabolomic analysis for first-trimester trisomy 18 detection. , 2013, American journal of obstetrics and gynecology.

[10]  D. Wishart,et al.  Metabolomic analysis for first-trimester Down syndrome prediction. , 2013, American journal of obstetrics and gynecology.

[11]  Jan Koster,et al.  FOXO3a is a major target of inactivation by PI3K/AKT signaling in aggressive neuroblastoma. , 2013, Cancer research.

[12]  Peixin Yang,et al.  c-Jun NH2-Terminal Kinase 1/2 and Endoplasmic Reticulum Stress as Interdependent and Reciprocal Causation in Diabetic Embryopathy , 2013, Diabetes.

[13]  E. A. Reece,et al.  Oxidative Stress–Induced JNK1/2 Activation Triggers Proapoptotic Signaling and Apoptosis That Leads to Diabetic Embryopathy , 2012, Diabetes.

[14]  Xue Zhou,et al.  A novel bridge between oxidative stress and immunity: the interaction between hydrogen peroxide and human leukocyte antigen G in placental trophoblasts during preeclampsia. , 2012, American journal of obstetrics and gynecology.

[15]  E. A. Reece,et al.  SOD1 suppresses maternal hyperglycemia-increased iNOS expression and consequent nitrosative stress in diabetic embryopathy. , 2012, American journal of obstetrics and gynecology.

[16]  G. Oakley.  Failing to prevent birth defects caused by maternal diabetes mellitus. , 2012, American journal of obstetrics and gynecology.

[17]  Lorenzo D Botto,et al.  Lack of periconceptional vitamins or supplements that contain folic acid and diabetes mellitus-associated birth defects. , 2012, American journal of obstetrics and gynecology.

[18]  E. A. Reece,et al.  SOD1 overexpression in vivo blocks hyperglycemia-induced specific PKC isoforms: substrate activation and consequent lipid peroxidation in diabetic embryopathy. , 2011, American journal of obstetrics and gynecology.

[19]  E. A. Reece,et al.  Role of HIF-1α in maternal hyperglycemia-induced embryonic vasculopathy. , 2011, American journal of obstetrics and gynecology.

[20]  Peixin Yang,et al.  Hyperglycemia induces inducible nitric oxide synthase gene expression and consequent nitrosative stress via c-Jun N-terminal kinase activation. , 2010, American journal of obstetrics and gynecology.

[21]  Peixin Yang,et al.  Epigallocatechin-3-gallate ameliorates hyperglycemia-induced embryonic vasculopathy and malformation by inhibition of Foxo3a activation. , 2010, American journal of obstetrics and gynecology.

[22]  Katsuhiko Yano,et al.  FOXO3A genotype is strongly associated with human longevity , 2008, Proceedings of the National Academy of Sciences.

[23]  E. A. Reece,et al.  Demonstration of the Essential Role of Protein Kinase C Isoforms in Hyperglycemia-Induced Embryonic Malformations , 2008, Reproductive Sciences.

[24]  E. A. Reece,et al.  Involvement of c-Jun N-terminal kinases activation in diabetic embryopathy. , 2007, Biochemical and biophysical research communications.

[25]  E. Lam,et al.  FOXO transcription factors: key regulators of cell fate. , 2006, Biochemical Society transactions.

[26]  E. Lam,et al.  Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization. , 2006, Molecular endocrinology.

[27]  Toshio Ogihara,et al.  Apoptosis Signal-Regulating Kinase 1 Mediates Cellular Senescence Induced by High Glucose in Endothelial Cells , 2006, Diabetes.

[28]  Zheng‐gang Liu,et al.  JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. , 2006, Free radical biology & medicine.

[29]  E. Reece,et al.  Dietary vitamin and lipid therapy rescues aberrant signaling and apoptosis and prevents hyperglycemia-induced diabetic embryopathy in rats. , 2006, American journal of obstetrics and gynecology.

[30]  E. Greer,et al.  FOXO transcription factors at the interface between longevity and tumor suppression , 2005, Oncogene.

[31]  A. Jawerbaum,et al.  Peroxynitrites and impaired modulation of nitric oxide concentrations in embryos from diabetic rats during early organogenesis. , 2005, Reproduction.

[32]  W. Aird,et al.  Forkhead Transcription Factors Inhibit Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia*[boxs] , 2005, Journal of Biological Chemistry.

[33]  M. Hori,et al.  Apoptosis signal-regulating kinase 1 is involved not only in apoptosis but also in non-apoptotic cardiomyocyte death. , 2005, Biochemical and biophysical research communications.

[34]  Fuminori Tsuruta,et al.  JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3 , 2005, The Journal of cell biology.

[35]  M. Loeken,et al.  Hypoxic stress in diabetic pregnancy contributes to impaired embryo gene expression and defective development by inducing oxidative stress. , 2005, American journal of physiology. Endocrinology and metabolism.

[36]  H. Jasper,et al.  JNK Extends Life Span and Limits Growth by Antagonizing Cellular and Organism-Wide Responses to Insulin Signaling , 2005, Cell.

[37]  A. Jawerbaum,et al.  The role of alterations in arachidonic acid metabolism and nitric oxide homeostasis in rat models of diabetes during early pregnancy. , 2005, Current pharmaceutical design.

[38]  E. Reece,et al.  Aberrant patterns of cellular communication in diabetes-induced embryopathy in rats: II, apoptotic pathways. , 2005, American journal of obstetrics and gynecology.

[39]  K. Eguchi,et al.  Apoptosis and its pathway in early post-implantation embryos of diabetic rats. , 2005, Diabetes research and clinical practice.

[40]  K. Maiese,et al.  Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease , 2005, Progress in Neurobiology.

[41]  J. Bos,et al.  FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK , 2004, The EMBO journal.

[42]  L. Glimcher,et al.  Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes , 2004, Science.

[43]  M. Loeken,et al.  Activation of the hexosamine pathway causes oxidative stress and abnormal embryo gene expression: involvement in diabetic teratogenesis. , 2004, Birth defects research. Part A, Clinical and molecular teratology.

[44]  D. Jhon,et al.  Involvement of ROS and JNK1 in selenite-induced a poptosisin Chang liver cells , 2004, Experimental & Molecular Medicine.

[45]  Teiji Wada,et al.  Mitogen-activated protein kinases in apoptosis regulation , 2004, Oncogene.

[46]  Steven P. Gygi,et al.  Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase , 2004, Science.

[47]  Jau-Song Yu,et al.  Curcumin inhibits UV irradiation‐induced oxidative stress and apoptotic biochemical changes in human epidermoid carcinoma A431 cells , 2003, Journal of cellular biochemistry.

[48]  P. Coffer,et al.  FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons , 2003, The Journal of cell biology.

[49]  M. Weil,et al.  Nitric oxide is involved in establishing the balance between cell cycle progression and cell death in the developing neural tube. , 2003, Experimental cell research.

[50]  Y. Arita,et al.  Inhibition of c-Jun N-terminal kinase pathway improves cell viability in response to oxidant injury. , 2003, American journal of respiratory cell and molecular biology.

[51]  C. Szabó.  Multiple pathways of peroxynitrite cytotoxicity. , 2003, Toxicology letters.

[52]  M. Loeken,et al.  Oxidant regulation of gene expression and neural tube development: Insights gained from diabetic pregnancy on molecular causes of neural tube defects , 2003, Diabetologia.

[53]  A. Kessler,et al.  High glucose promotes mesangial cell apoptosis by oxidant-dependent mechanism. , 2003, American journal of physiology. Renal physiology.

[54]  M. Haneda,et al.  Progression of diabetic nephropathy. , 2003, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[55]  Quan-guang Zhang,et al.  Biphasic activation of apoptosis signal-regulating kinase 1-stress-activated protein kinase 1-c-Jun N-terminal protein kinase pathway is selectively mediated by Ca2+-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors involving oxidative stress following brain ischemia in rat hi , 2003, Neuroscience Letters.

[56]  A. Lin.  Activation of the JNK signaling pathway: Breaking the brake on apoptosis , 2003, BioEssays : news and reviews in molecular, cellular and developmental biology.

[57]  Rakesh Nagarajan,et al.  FOXO Proteins Regulate Tumor Necrosis Factor-related Apoptosis Inducing Ligand Expression , 2002, The Journal of Biological Chemistry.

[58]  Yusuke Nakamura,et al.  Involvement of FKHR-Dependent TRADD Expression in Chemotherapeutic Drug-Induced Apoptosis , 2002, Molecular and Cellular Biology.

[59]  A. Lin,et al.  The true face of JNK activation in apoptosis , 2002, Aging cell.

[60]  G. Soltész,et al.  Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children. , 2002, Prostaglandins, leukotrienes, and essential fatty acids.

[61]  Geert J. P. L. Kops,et al.  Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress , 2002, Nature.

[62]  M. Loeken,et al.  Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy. , 2002, Diabetes.

[63]  Sang-Oh Yoon,et al.  Sustained Production of H2O2Activates Pro-matrix Metalloproteinase-2 through Receptor Tyrosine Kinases/Phosphatidylinositol 3-Kinase/NF-κB Pathway* , 2002, The Journal of Biological Chemistry.

[64]  T. Peng,et al.  Development of Heart Failure and Congenital Septal Defects in Mice Lacking Endothelial Nitric Oxide Synthase , 2002, Circulation.

[65]  Y. Fujita,et al.  Ebselen attenuates oxidative stress‐induced apoptosis via the inhibition of the c‐Jun N‐terminal kinase and activator protein‐1 signalling pathway in PC12 cells , 2002, British journal of pharmacology.

[66]  M. Ueno,et al.  Redox control of cell death. , 2002, Antioxidants & redox signaling.

[67]  D. Feig,et al.  Type 2 diabetes in pregnancy: a growing concern , 2002, The Lancet.

[68]  Xianglin Shi,et al.  Differential role of hydrogen peroxide in UV-induced signal transduction , 2002, Molecular and Cellular Biochemistry.

[69]  S. R. Datta,et al.  DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein , 2002, Science.

[70]  H. Ichijo,et al.  Activation of apoptosis signal‐regulating kinase 1 by the stress‐induced activating phosphorylation of pre‐formed oligomer , 2002, Journal of cellular physiology.

[71]  A. Bode,et al.  Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate. , 2002, Cancer research.

[72]  L. Kirshenbaum,et al.  Suppression of Akt Signaling Induces Fas Ligand Expression: Involvement of Caspase and Jun Kinase Activation in Akt-Mediated Fas Ligand Regulation , 2002, Molecular and Cellular Biology.

[73]  E. Reece,et al.  Aberrant patterns of cellular communication in diabetes-induced embryopathy I. Membrane signalling , 2002, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[74]  A. Ornoy,et al.  Vitamins C and E improve rat embryonic antioxidant defense mechanism in diabetic culture medium. , 2001, Teratology.

[75]  F. McCormick,et al.  Transcriptional activation of TRADD mediates p53-independent radiation-induced apoptosis of glioma cells , 2001, Oncogene.

[76]  M. Jung,et al.  Role of ATM in Oxidative Stress-mediated c-Jun Phosphorylation in Response to Ionizing Radiation and CdCl2 * , 2001, The Journal of Biological Chemistry.

[77]  J. Avruch,et al.  Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. , 2001, Physiological reviews.

[78]  T Takahashi,et al.  ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis , 2001, EMBO reports.

[79]  K. Moley.  Hyperglycemia and apoptosis: mechanisms for congenital malformations and pregnancy loss in diabetic women , 2001, Trends in Endocrinology & Metabolism.

[80]  A. Jawerbaum,et al.  Modulation of PGE2 generation in the diabetic embryo: effect of nitric oxide and superoxide dismutase. , 2001, Prostaglandins, leukotrienes, and essential fatty acids.

[81]  James E. Ferrell,et al.  c-Jun N-terminal Kinase Activation in Xenopus laevis Eggs and Embryos , 2001, The Journal of Biological Chemistry.

[82]  R. Davis,et al.  Signal Transduction by the JNK Group of MAP Kinases , 2000, Cell.

[83]  P A Insel,et al.  Protein kinase C isozymes and the regulation of diverse cell responses. , 2000, American journal of physiology. Lung cellular and molecular physiology.

[84]  T. Finkel.  Redox‐dependent signal transduction , 2000, FEBS letters.

[85]  R. Flavell,et al.  JNK is required for effector T-cell function but not for T-cell activation , 2000, Nature.

[86]  F. Urano,et al.  Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. , 2000, Science.

[87]  U. Eriksson,et al.  Pathogenesis of Diabetes-Induced Congenital Malformations , 2000, Upsala journal of medical sciences.

[88]  M. Loeken,et al.  Evidence that elevated glucose causes altered gene expression, apoptosis, and neural tube defects in a mouse model of diabetic pregnancy. , 1999, Diabetes.

[89]  R. Kohen,et al.  Role of reactive oxygen species (ROS) in the diabetes-induced anomalies in rat embryos in vitro: reduction in antioxidant enzymes and low-molecular-weight antioxidants (LMWA) may be the causative factor for increased anomalies. , 1999, Teratology.

[90]  S. Nagataki,et al.  Significance of glutathione-dependent antioxidant system in diabetes-induced embryonic malformations. , 1999, Diabetes.

[91]  P. Rakic,et al.  The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development , 1999, Neuron.

[92]  N. Welsh,et al.  Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment. , 1999, Diabetes.

[93]  M. Greenberg,et al.  Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor , 1999, Cell.

[94]  Paul J Thornalley,et al.  Teratogenicity of 3-deoxyglucosone and diabetic embryopathy. , 1998, Diabetes.

[95]  K. Miyazono,et al.  ASK1 is essential for JNK/SAPK activation by TRAF2. , 1998, Molecular cell.

[96]  N. Welsh,et al.  Apoptosis in embryos of diabetic rats. , 1998, Pharmacology & toxicology.

[97]  Kohei Miyazono,et al.  Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1 , 1998, The EMBO journal.

[98]  G. Wolf,et al.  Distribution of the endothelial constitutive nitric oxide synthase in the developing rat brain: an immunohistochemical study , 1998, Brain Research.

[99]  W. Cavenee,et al.  Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. , 1998, Genomics.

[100]  U. Eriksson,et al.  Decreased catalase activity in malformation-prone embryos of diabetic rats. , 1997, Teratology.

[101]  M. Loeken,et al.  Neural Tube Defects in Embryos of Diabetic Mice: Role of the Pax-3 Gene and Apoptosis , 1997, Diabetes.

[102]  E. Reece,et al.  Prevention of diabetic embryopathy in offspring of diabetic rats with use of a cocktail of deficient substrates and an antioxidant. , 1997, American journal of obstetrics and gynecology.

[103]  E. Reece,et al.  Dietary polyunsaturated fatty acid prevents malformations in offspring of diabetic rats. , 1996, American journal of obstetrics and gynecology.

[104]  A. Chinnaiyan,et al.  FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis (*) , 1996, The Journal of Biological Chemistry.

[105]  Hong-Bing Shu,et al.  TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways , 1996, Cell.

[106]  E. Reece,et al.  Prevention of diabetes-associated embryopathy by overexpression of the free radical scavenger copper zinc superoxide dismutase in transgenic mouse embryos. , 1995, American journal of obstetrics and gynecology.

[107]  S. Nagataki,et al.  Significance of Glutathione Depletion and Oxidative Stress in Early Embryogenesis in Glucose-Induced Rat Embryo Culture , 1995, Diabetes.

[108]  D. Betteridge,et al.  Plasma 8‐epi‐PGF2α levels are elevated in individuals with non‐insulin dependent diabetes mellitus , 1995, FEBS letters.

[109]  D. Goeddel,et al.  The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation , 1995, Cell.

[110]  J. Camonis,et al.  A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain (*) , 1995, The Journal of Biological Chemistry.

[111]  M. Juchau,et al.  Dysmorphogenic effects of nitric oxide (NO) and NO-synthase inhibition: studies with intra-amniotic injections of sodium nitroprusside and NG-monomethyl-L-arginine. , 1994, Teratology.

[112]  S. Moncada,et al.  Nitric oxide: physiology, pathophysiology, and pharmacology. , 1991, Pharmacological reviews.

[113]  J. Morrow,et al.  A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[114]  E. A. Reece,et al.  45: Role of HIF-1alpha in maternal hyperglycemia-induced embryonic vasculopathy , 2011 .

[115]  F. Urano,et al.  Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation , 2005, Cell Death and Differentiation.

[116]  S. Kyosseva.  Mitogen-activated protein kinase signaling. , 2004, International review of neurobiology.

[117]  H. Forman,et al.  Redox signaling and the MAP kinase pathways , 2003, BioFactors.

[118]  M. Torres.  Mitogen-activated protein kinase pathways in redox signaling. , 2003, Frontiers in bioscience : a journal and virtual library.

[119]  C. McMaster,et al.  Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis. , 2002, Biological research.

[120]  A. Srivastava.  High glucose-induced activation of protein kinase signaling pathways in vascular smooth muscle cells: a potential role in the pathogenesis of vascular dysfunction in diabetes (review). , 2002, International journal of molecular medicine.

[121]  C. Widmann,et al.  Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. , 1999, Physiological reviews.

[122]  A. Jawerbaum,et al.  Increased prostaglandin E generation and enhanced nitric oxide synthase activity in the non-insulin-dependent diabetic embryo during organogenesis. , 1998, Reproduction, fertility, and development.

[123]  D. Häussinger,et al.  Menadione induces both necrosis and apoptosis in rat pancreatic acinar AR4-2J cells. , 1997, Free radical biology & medicine.

[124]  S. Gangolli,et al.  Malformations induced in cultured rat embryos by enzymically generated active oxygen species. , 1986, Teratogenesis, carcinogenesis, and mutagenesis.