A Drosophila platform identifies a novel, personalized therapy for a patient with adenoid cystic carcinoma

[1]  M. McGurk,et al.  Major and minor salivary gland tumours. , 2020, Critical reviews in oncology/hematology.

[2]  A. Okamoto,et al.  FAT4 silencing promotes epithelial-to-mesenchymal transition and invasion via regulation of YAP and β-catenin activity in ovarian cancer , 2020, BMC Cancer.

[3]  L. Gudas,et al.  Mutations in long-lived epithelial stem cells and their clonal progeny in pre-malignant lesions and in oral squamous cell carcinoma. , 2020, Carcinogenesis.

[4]  Shenglin Huang,et al.  Genomic and Transcriptomic Characterization of Sporadic Medullary Thyroid Carcinoma. , 2020, Thyroid : official journal of the American Thyroid Association.

[5]  Yaoqing Li,et al.  Integrated characterisation of cancer genes identifies key molecular biomarkers in stomach adenocarcinoma , 2020, Journal of Clinical Pathology.

[6]  G. Purkalne,et al.  Deletions in metastatic colorectal cancer with chromothripsis. , 2019, Experimental oncology.

[7]  Y. Kong,et al.  Association of XPD Asp312Asn polymorphism and response to oxaliplatin-based first-line chemotherapy and survival in patients with metastatic colorectal cancer. , 2019, Advances in clinical and experimental medicine : official organ Wroclaw Medical University.

[8]  Siteng Chen,et al.  A novel gene signature combination improves the prediction of overall survival in urinary bladder cancer , 2019, Journal of Cancer.

[9]  P. A. Futreal,et al.  Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma. , 2019, The Journal of clinical investigation.

[10]  E. Schadt,et al.  A personalized platform identifies trametinib plus zoledronate for a patient with KRAS-mutant metastatic colorectal cancer , 2019, Science Advances.

[11]  X. Yi,et al.  Comprehensive genomic variation profiling of cervical intraepithelial neoplasia and cervical cancer identifies potential targets for cervical cancer early warning , 2018, Journal of Medical Genetics.

[12]  R. Perona,et al.  XPA, XPC, and XPD Modulate Sensitivity in Gastric Cisplatin Resistance Cancer Cells , 2018, Front. Pharmacol..

[13]  C. Cole,et al.  The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers , 2018, Nature Reviews Cancer.

[14]  Wen-Jie Guo,et al.  The effects of beta-blocker use on cancer prognosis: a meta-analysis based on 319,006 patients , 2018, OncoTargets and therapy.

[15]  Avner Schlessinger,et al.  A Whole Animal Platform to Advance A Clinical Kinase Inhibitor Into New Disease Space , 2017, Nature chemical biology.

[16]  Dong Zhao,et al.  Association Between the Asp312Asn, Lys751Gln, and Arg156Arg Polymorphisms in XPD and the Risk of Prostate Cancer , 2017, Technology in cancer research & treatment.

[17]  Wei Zhang,et al.  Genetic Polymorphisms and Platinum-based Chemotherapy Treatment Outcomes in Patients with Non-Small Cell Lung Cancer: A Genetic Epidemiology Study Based Meta-analysis , 2017, Scientific Reports.

[18]  E. Lenkiewicz,et al.  A phase 2 study of vorinostat in locally advanced, recurrent, or metastatic adenoid cystic carcinoma , 2017, Oncotarget.

[19]  Wei-fa Yang,et al.  Risk factors and prognosis for salivary gland adenoid cystic carcinoma in southern china , 2017, Medicine.

[20]  O. Sansom,et al.  Functional exploration of colorectal cancer genomes using Drosophila , 2016, Nature Communications.

[21]  Masashi Kato,et al.  Propranolol induces a favourable shift of anti-tumor immunity in a murine spontaneous model of melanoma , 2016, Oncotarget.

[22]  R. Cagan,et al.  Drosophila Cancer Models Identify Functional Differences between Ret Fusions. , 2016, Cell reports.

[23]  G. Stenman,et al.  The landscape of gene fusions and somatic mutations in salivary gland neoplasms - Implications for diagnosis and therapy. , 2016, Oral oncology.

[24]  Dung Nguyen Trung,et al.  Chronic stress increases experimental pancreatic cancer growth, reduces survival and can be antagonised by beta-adrenergic receptor blockade. , 2016, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

[25]  E. Boerwinkle,et al.  dbNSFP v3.0: A One‐Stop Database of Functional Predictions and Annotations for Human Nonsynonymous and Splice‐Site SNVs , 2016, Human mutation.

[26]  B. Levine,et al.  Drosophila Lung Cancer Models Identify Trametinib plus Statin as Candidate Therapeutic. , 2016, Cell reports.

[27]  L. Wood,et al.  Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma , 2016, Cancer Prevention Research.

[28]  P. A. Futreal,et al.  Novel MYBL1 Gene Rearrangements with Recurrent MYBL1–NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations , 2015, Clinical Cancer Research.

[29]  Matthew E. Berginski,et al.  β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion , 2015, Breast Cancer Research.

[30]  Zhongyang Zhang,et al.  SAAS-CNV: A Joint Segmentation Approach on Aggregated and Allele Specific Signals for the Identification of Somatic Copy Number Alterations with Next-Generation Sequencing Data , 2015, PLoS Comput. Biol..

[31]  J. Snowden,et al.  The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours , 2015, British Journal of Cancer.

[32]  P. Bradley,et al.  Adenoid cystic carcinoma of the head and neck--An update. , 2015, Oral oncology.

[33]  S. Artavanis-Tsakonas,et al.  The Notch-mediated hyperplasia circuitry in Drosophila reveals a Src-JNK signaling axis , 2015, eLife.

[34]  Jian Sun,et al.  Genetic landscape of esophageal squamous cell carcinoma , 2014, Nature Genetics.

[35]  G. Cao,et al.  Associations of Polymorphisms in DNA Repair Genes and MDR1 Gene with Chemotherapy Response and Survival of Non-Small Cell Lung Cancer , 2014, PloS one.

[36]  R. Cagan,et al.  A Jnk–Rho–Actin remodeling positive feedback network directs Src-driven invasion , 2014, Oncogene.

[37]  C. Antonescu,et al.  Phase II Study of Lenvatinib in Patients With Progressive, Recurrent or Metastatic Adenoid Cystic Carcinoma. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[38]  J. Shendure,et al.  A general framework for estimating the relative pathogenicity of human genetic variants , 2014, Nature Genetics.

[39]  P. Stephens,et al.  Comprehensive Genomic Profiling of Relapsed and Metastatic Adenoid Cystic Carcinomas by Next-generation Sequencing Reveals Potential New Routes to Targeted Therapies , 2014, The American journal of surgical pathology.

[40]  E. Boyce,et al.  Tofacitinib , 2013, Reactions Weekly.

[41]  M. Stratton,et al.  Whole exome sequencing of adenoid cystic carcinoma. , 2013, The Journal of clinical investigation.

[42]  Benjamin J. Raphael,et al.  The Mutational Landscape of Adenoid Cystic Carcinoma , 2013, Nature Genetics.

[43]  E. R. Andersson,et al.  Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ , 2012, Oncogene.

[44]  P. A. Futreal,et al.  Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma , 2012, Genes, chromosomes & cancer.

[45]  Kevan M. Shokat,et al.  Chemical genetic discovery of targets and anti-targets for cancer polypharmacology , 2012, Nature.

[46]  Norbert Perrimon,et al.  A genome-scale shRNA resource for transgenic RNAi in Drosophila , 2011, Nature Methods.

[47]  R. West,et al.  MYB Expression and Translocation in Adenoid Cystic Carcinomas and Other Salivary Gland Tumors With Clinicopathologic Correlation , 2011, The American journal of surgical pathology.

[48]  H. Horlings,et al.  Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck , 2009, Proceedings of the National Academy of Sciences.

[49]  R. Read,et al.  Differing Src signaling levels have distinct outcomes in Drosophila. , 2007, Cancer research.

[50]  R. Maeda,et al.  An optimized transgenesis system for Drosophila using germ-line-specific φC31 integrases , 2007, Proceedings of the National Academy of Sciences.

[51]  Jean-Philippe Vert,et al.  An accurate and interpretable model for siRNA efficacy prediction , 2006, BMC Bioinformatics.

[52]  E. Monsalve,et al.  Notch-1 Up-Regulation and Signaling following Macrophage Activation Modulates Gene Expression Patterns Known to Affect Antigen-Presenting Capacity and Cytotoxic Activity1 , 2006, The Journal of Immunology.

[53]  L. Herzenberg,et al.  Functional Evolution of the Vertebrate Myb Gene Family , 2005, Genetics.

[54]  J. O’Shea,et al.  Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor , 2003, Science.

[55]  G. Ramsay,et al.  Drosophila myb exerts opposing effects on S phase, promoting proliferation and suppressing endoreduplication. , 2002, Development.

[56]  H. Okano,et al.  Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling. , 2002, Development.

[57]  J. Lipsick,et al.  Functional evolution of the Myb oncogene family. , 2001, Blood cells, molecules & diseases.

[58]  V. Heinemann,et al.  Gemcitabine: metabolism, mechanisms of action, and self-potentiation. , 1995, Seminars in oncology.

[59]  N. Perrimon,et al.  Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. , 1993, Development.

[60]  J. Lipsick,et al.  Carboxy-terminal elements of c-Myb negatively regulate transcriptional activation in cis and in trans. , 1992, Genes & development.

[61]  T. Nagase,et al.  Delineation of three functional domains of the transcriptional activator encoded by the c-myb protooncogene. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[62]  J. Bishop,et al.  Transcriptional activation by the v-myb oncogene and its cellular progenitor, c-myb , 1989, Cell.

[63]  T. Gonda,et al.  Activation of c‐myb by carboxy‐terminal truncation: relationship to transformation of murine haemopoietic cells in vitro. , 1989, The EMBO journal.

[64]  R. Shaddy,et al.  Beta-Adrenergic Receptor Blockade , 2018 .

[65]  Hugo J. Bellen,et al.  Notch Signaling , 2014, Methods in Molecular Biology.

[66]  Ronald Breslow,et al.  Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug , 2007, Nature Biotechnology.

[67]  D. Larson,et al.  Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosis. , 2006, Developmental cell.

[68]  C. Werning.  [Rheumatoid arthritis]. , 1983, Medizinische Monatsschrift fur Pharmazeuten.