Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins

The PAT family of proteins has been identified in eukaryotic species as diverse as vertebrates, insects, and amebazoa. These proteins share a highly conserved sequence organization and avidity for the surfaces of intracellular, neutral lipid storage droplets. The current nomenclature of the various members lacks consistency and precision, deriving more from historic context than from recognition of evolutionary relationship and shared function. In consultation with the Mouse Genomic Nomenclature Committee, the Human Genome Organization Genomic Nomenclature Committee, and conferees at the 2007 FASEB Conference on Lipid Droplets: Metabolic Consequences of the Storage of Neutral Lipids, we have established a unifying nomenclature for the gene and protein family members. Each gene member will incorporate the root term PERILIPIN (PLIN), the founding gene of the PAT family, with the different genes/proteins numbered sequentially.

[1]  A. Chawla,et al.  Cidea is associated with lipid droplets and insulin sensitivity in humans , 2008, Proceedings of the National Academy of Sciences.

[2]  Richard G. W. Anderson,et al.  Identification of a novel N-terminal hydrophobic sequence that targets proteins to lipid droplets , 2008, Journal of Cell Science.

[3]  Yinxin Zhang,et al.  Molecular evolution of Cide family proteins: Novel domain formation in early vertebrates and the subsequent divergence , 2008, BMC Evolutionary Biology.

[4]  A. Shavinskaya,et al.  The Lipid Droplet Binding Domain of Hepatitis C Virus Core Protein Is a Major Determinant for Efficient Virus Assembly* , 2007, Journal of Biological Chemistry.

[5]  P. Shewry,et al.  Properties and exploitation of oleosins. , 2007, Biotechnology advances.

[6]  C. Sztalryd,et al.  LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues. , 2007, Biochimica et biophysica acta.

[7]  N. Wolins,et al.  OXPAT/PAT-1 Is a PPAR-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization , 2006, Diabetes.

[8]  T. Osumi,et al.  MLDP, a Novel PAT Family Protein Localized to Lipid Droplets and Enriched in the Heart, Is Regulated by Peroxisome Proliferator-activated Receptor α* , 2006, Journal of Biological Chemistry.

[9]  A. Kimmel,et al.  Post-translational Regulation of Adipose Differentiation-related Protein by the Ubiquitin/Proteasome Pathway* , 2005, Journal of Biological Chemistry.

[10]  C. Allis,et al.  Taking LSD1 to a New High , 2005, Cell.

[11]  Rajesh T. Patel,et al.  Activation of the Lipid Droplet Controls the Rate of Lipolysis of Triglycerides in the Insect Fat Body* , 2005, Journal of Biological Chemistry.

[12]  S. Souza,et al.  Lipase-selective Functional Domains of Perilipin A Differentially Regulate Constitutive and Protein Kinase A-stimulated Lipolysis* , 2003, Journal of Biological Chemistry.

[13]  N. Wolins,et al.  Adipocyte Protein S3-12 Coats Nascent Lipid Droplets* , 2003, Journal of Biological Chemistry.

[14]  P. Rørth,et al.  Drosophila Perilipin/ADRP homologue Lsd2 regulates lipid metabolism , 2003, Mechanisms of Development.

[15]  D. Eliezer,et al.  A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins. , 2003, Journal of molecular biology.

[16]  H. Jäckle,et al.  Control of Fat Storage by a Drosophila PAT Domain Protein , 2003, Current Biology.

[17]  A. Kimmel,et al.  Functional Studies on Native and Mutated Forms of Perilipins , 2003, The Journal of Biological Chemistry.

[18]  Vidya Subramanian,et al.  The Central Domain Is Required to Target and Anchor Perilipin A to Lipid Droplets* , 2003, The Journal of Biological Chemistry.

[19]  B. Oliver,et al.  Functional Conservation for Lipid Storage Droplet Association among Perilipin, ADRP, and TIP47 (PAT)-related Proteins in Mammals,Drosophila, and Dictyostelium * , 2002, The Journal of Biological Chemistry.

[20]  N. Copeland,et al.  The murine perilipin gene: the lipid droplet-associated perilipins derive from tissue-specific, mRNA splice variants and define a gene family of ancient origin , 2001, Mammalian Genome.

[21]  S. Pfeffer,et al.  TIP47 Is Not a Component of Lipid Droplets* , 2001, The Journal of Biological Chemistry.

[22]  S. Munro,et al.  Accumulation of Caveolin in the Endoplasmic Reticulum Redirects the Protein to Lipid Storage Droplets , 2001, The Journal of cell biology.

[23]  D. Brasaemle,et al.  TIP47 Associates with Lipid Droplets* , 2001, The Journal of Biological Chemistry.

[24]  B. Sumegi,et al.  Cloning and sequence analysis of cDNAs encoding human placental tissue protein 17 (PP17) variants. , 1998, European journal of biochemistry.

[25]  H. Rackwitz,et al.  Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases , 1998, Cell and Tissue Research.

[26]  H. Lodish,et al.  Cloning of cell-specific secreted and surface proteins by subtractive antibody screening , 1998, Nature Biotechnology.

[27]  S. Pfeffer,et al.  TIP47: A Cargo Selection Device for Mannose 6-Phosphate Receptor Trafficking , 1998, Cell.

[28]  T. Barber,et al.  Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. , 1997, Journal of lipid research.

[29]  M. Schnölzer,et al.  Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane. , 1996, The Biochemical journal.

[30]  A. Kimmel,et al.  Perilipins Are Associated with Cholesteryl Ester Droplets in Steroidogenic Adrenal Cortical and Leydig Cells (*) , 1995, The Journal of Biological Chemistry.

[31]  T. Barber,et al.  Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes. , 1995, Journal of lipid research.

[32]  A. Kimmel,et al.  Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[33]  A. Greenberg,et al.  Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. , 1991, The Journal of biological chemistry.

[34]  A. Greenberg,et al.  Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation. , 1990, The Journal of biological chemistry.

[35]  C. Allis,et al.  Taking LSD 1 to a new high. , 2005, Cell.

[36]  S. Harris,et al.  Molecular cloning of a differentiation-related mRNA in the adipogenic cell line 1246. , 1992, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.