Single-molecule dynamics of gating in a neurotransmitter transporter homolog
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Jonathan A. Javitch | Harel Weinstein | Lei Shi | Scott C. Blanchard | Daniel S. Terry | H. Weinstein | Lei Shi | J. Javitch | S. Blanchard | Yongfang Zhao | Yongfang Zhao | Daniel Terry
[1] Jonathan A. Javitch,et al. Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation , 2009, Proceedings of the National Academy of Sciences.
[2] T. Ha. Need for Speed: Mechanical Regulation of a Replicative Helicase , 2007, Cell.
[3] Sergei Yu Noskov,et al. Molecular mechanism of ion-ion and ion-substrate coupling in the Na+-dependent leucine transporter LeuT. , 2008, Biophysical journal.
[4] Ignacio Tinoco,et al. Following translation by single ribosomes one codon at a time , 2008, Nature.
[5] H. Noji,et al. F1-ATPase: a highly efficient rotary ATP machine. , 2000, Essays in biochemistry.
[6] Eric Gouaux,et al. Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters , 2005, Nature.
[7] G. Rudnick. Mechanisms of Biogenic Amine Neurotransmitter Transporters , 2002 .
[8] G. Rudnick,et al. Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence. , 1994, The Journal of biological chemistry.
[9] H. Kaback,et al. The Cys154-->Gly mutation in LacY causes constitutive opening of the hydrophilic periplasmic pathway. , 2008, Journal of molecular biology.
[10] Xiangxu Kong,et al. Single-molecule FRET reveals sugar-induced conformational dynamics in LacY , 2007, Proceedings of the National Academy of Sciences.
[11] E. Gouaux,et al. Structure and Mechanism of a Na+-Independent Amino Acid Transporter , 2009, Science.
[12] P. Selvin,et al. Single-molecule fluorescence to study molecular motors , 2007, Quarterly Reviews of Biophysics.
[13] X. Zhuang. Single-molecule RNA science. , 2005, Annual review of biophysics and biomolecular structure.
[14] Birgit Schiøtt,et al. Substrate binding and formation of an occluded state in the leucine transporter. , 2008, Biophysical journal.
[15] A. Pyle. Translocation and unwinding mechanisms of RNA and DNA helicases. , 2008, Annual review of biophysics.
[16] Nathan O'Connor,et al. Identification of two distinct hybrid state intermediates on the ribosome. , 2007, Molecular cell.
[17] W. Greenleaf,et al. Single-molecule studies of RNA polymerase: motoring along. , 2008, Annual review of biochemistry.
[18] Eric Gouaux,et al. A Competitive Inhibitor Traps LeuT in an Open-to-Out Conformation , 2008, Science.
[19] J. Javitch,et al. How did the neurotransmitter cross the bilayer? A closer view , 2005, Current Opinion in Neurobiology.
[20] K. Kobs,et al. Rhodamine B and rhodamine 101 as reference substances for fluorescence quantum yield measurements , 1980 .
[21] Eric Gouaux,et al. Antidepressant binding site in a bacterial homologue of neurotransmitter transporters , 2007, Nature.
[22] R. Gainetdinov,et al. Plasma membrane monoamine transporters: structure, regulation and function , 2003, Nature Reviews Neuroscience.
[23] J. Javitch,et al. Monitoring the function of membrane transport proteins in detergent-solubilized form , 2007, Proceedings of the National Academy of Sciences.
[24] L. Iversen,et al. Neurotransmitter transporters and their impact on the development of psychopharmacology , 2006, British journal of pharmacology.
[25] A. R. Williams,et al. Relative fluorescence quantum yields using a computer-controlled luminescence spectrometer , 1983 .
[26] R. Vale. Myosin V motor proteins , 2003, The Journal of cell biology.
[27] Feng Qin,et al. Restoration of single-channel currents using the segmental k-means method based on hidden Markov modeling. , 2004, Biophysical journal.
[28] B. Kanner,et al. Mutation of Arginine 44 of GAT-1, a (Na+ + Cl−)-coupled γ-Aminobutyric Acid Transporter from Rat Brain, Impairs Net Flux but Not Exchange* , 2000, The Journal of Biological Chemistry.
[29] T. Ha,et al. A survey of single-molecule techniques in chemical biology. , 2007, ACS chemical biology.
[30] S. Amara,et al. Neurotransmitter transporters as molecular targets for addictive drugs. , 1998, Drug and alcohol dependence.
[31] W. Eaton,et al. Protein folding studied by single-molecule FRET. , 2008, Current opinion in structural biology.
[32] James B. Munro,et al. Mitigating unwanted photophysical processes for improved single-molecule fluorescence imaging. , 2009, Biophysical journal.
[33] F. Qin,et al. Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events. , 1996, Biophysical journal.
[34] C. J. Lewis,et al. Cyanine dye labeling reagents: sulfoindocyanine succinimidyl esters. , 1993, Bioconjugate chemistry.
[35] M. Reith,et al. Antidepressant specificity of serotonin transporter suggested by three LeuT–SSRI structures , 2009, Nature Structural &Molecular Biology.
[36] J. Lakowicz. Principles of fluorescence spectroscopy , 1983 .
[37] D. Beckett,et al. A minimal peptide substrate in biotin holoenzyme synthetase‐catalyzed biotinylation , 2008, Protein science : a publication of the Protein Society.
[38] W E Moerner,et al. Single-molecule fluorescence spectroscopy and microscopy of biomolecular motors. , 2004, Annual review of physical chemistry.
[39] Harel Weinstein,et al. An Intracellular Interaction Network Regulates Conformational Transitions in the Dopamine Transporter* , 2008, Journal of Biological Chemistry.
[40] Benoît Roux,et al. Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms. , 2008, Journal of molecular biology.
[41] W. Schaffner,et al. A rapid, sensitive, and specific method for the determination of protein in dilute solution. , 1973, Analytical biochemistry.
[42] R. Ranganathan,et al. Evolutionarily conserved pathways of energetic connectivity in protein families. , 1999, Science.
[43] Steven Chu,et al. tRNA dynamics on the ribosome during translation. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[44] Stephan O. Krause,et al. Identification and Selective Inhibition of the Channel Mode of the Neuronal GABA Transporter 1 , 2005, Molecular Pharmacology.
[45] S. Blanchard. Single-molecule observations of ribosome function. , 2009, Current opinion in structural biology.
[46] Anne Marie Jørgensen,et al. Molecular Dynamics Simulations of Na+/Cl−‐Dependent Neurotransmitter Transporters in a Membrane‐Aqueous System , 2007, ChemMedChem.
[47] Da-Neng Wang,et al. LeuT-Desipramine Structure Reveals How Antidepressants Block Neurotransmitter Reuptake , 2007, Science.
[48] Harel Weinstein,et al. A Comprehensive Structure-Based Alignment of Prokaryotic and Eukaryotic Neurotransmitter/Na+ Symporters (NSS) Aids in the Use of the LeuT Structure to Probe NSS Structure and Function , 2006, Molecular Pharmacology.
[49] Rahul Roy,et al. A practical guide to single-molecule FRET , 2008, Nature Methods.
[50] Harel Weinstein,et al. The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site. , 2008, Molecular cell.