Design of highly efficient receptor sites by combination of cyclodextrin units and molecular cavity in TiO2 ultrathin layer.

A highly effective approach was developed for sensitive detection of organic substances in water. In order to achieve high sensitivity and selective detection for aromatic compounds, cyclodextrin (CD) hosts and imprinting effects were combined to fabricate binding sites within TiO(2) ultrathin layer. The electrode surface was modified with ultrathin TiO(2) gel film containing a 2:1 complex of beta-CD and bisphenol A (BPA), and then the BPA moiety was removed by washing. The resulting BPA-imprinted TiO(2)/beta-CD film showed specific and sensitive detection of BPA, as confirmed by quartz crystal microbalance (QCM) and cyclic surface-polarization impedance (cSPI) measurements. The high selectivity for BPA relative to structurally related guest molecules was estimated to be 1.6-3.4 at the guest concentration of 2x10(-7)M, and was considered to arise from the synergic effect of the binding site.

[1]  Seung-Woo Lee,et al.  Regioselective imprinting of anthracenecarboxylic acids onto TiO2 gel ultrathin films: an approach to thin film sensor , 2005 .

[2]  Kenshi Hayashi,et al.  Odor sensor with water membrane using surface polarity controlling method and analysis of responses to partial structures of odor molecules , 2004 .

[3]  Emilia Morallón,et al.  Electrochemical behaviour of benzene on platinum electrodes , 2000 .

[4]  M. Sluyters-Rehbach,et al.  The analysis of electrode impedances complicated by the presence of a constant phase element , 1984 .

[5]  Seung-Woo Lee,et al.  Enantioselective Binding of Amino Acid Derivatives onto Imprinted TiO2 Ultrathin Films , 2002 .

[6]  T. Kunitake,et al.  Stepwise Adsorption of Metal Alkoxides on Hydrolyzed Surfaces: A Surface Sol-Gel Process. , 1996 .

[7]  Kenshi Hayashi,et al.  Detection of aromatic nitro compounds with electrode polarization controlling sensor , 2005 .

[8]  P. Bühlmann,et al.  Carrier-Based Ion-Selective Electrodes and Bulk Optodes. 2. Ionophores for Potentiometric and Optical Sensors. , 1998, Chemical reviews.

[9]  Olof Ramström,et al.  Peer Reviewed: Molecular Imprinting: New Possibilities for Sensor Technology , 1997 .

[10]  T. Pajkossy.  Capacitance dispersion on solid electrodes: anion adsorption studies on gold single crystal electrodes , 1997 .

[11]  C. Rao,et al.  Supramolecular Organization and Materials Design , 2008 .

[12]  Seung-Woo Lee,et al.  Molecular imprinting in ultrathin titania gel films via surface sol–gel process , 2004 .

[13]  Kurt D. Benkstein,et al.  Luminescent sensor molecules based on coordinated metals: A review of recent developments , 2000 .

[14]  J. Mosinger,et al.  CYCLODEXTRINS IN ANALYTICAL CHEMISTRY , 2001 .

[15]  T. Pajkossy,et al.  On the origin of capacitance dispersion of rough electrodes , 2000 .

[16]  G. Sauerbrey.  Verwendung von Schwingquarzen zur Wägung dünner Schichten und zur Mikrowägung , 1959 .

[17]  I. Willner,et al.  Tailored chemosensors for chloroaromatic acids using molecular imprinted TiO2 thin films on ion-sensitive field-effect transistors. , 2001, Analytical chemistry.

[18]  Kiyoshi Toko,et al.  Functionalization of gold surfaces using benzene-patterned self-assembled monolayers for surface-polarization controlling method , 2003 .

[19]  G. Sauerbrey,et al.  Use of quartz vibration for weighing thin films on a microbalance , 1959 .

[20]  Izumi Ichinose,et al.  Alternate Molecular Layers of Metal Oxides and Hydroxyl Polymers Prepared by the Surface Sol‐Gel Process , 1998 .

[21]  Izumi Ichinose,et al.  Molecular Imprinting of Azobenzene Carboxylic Acid on a TiO2 Ultrathin Film by the Surface Sol-Gel Process , 1998 .

[22]  G. Wulff.  Molecular Imprinting in Cross‐Linked Materials with the Aid of Molecular Templates— A Way towards Artificial Antibodies , 1995 .