Efficient Photoluminescence of Mn2+-Doped ZnS Quantum Dots Excited by Two-Photon Absorption in Near-Infrared Window II

Highly fluorescing biological labels with excitation in near-infrared window II have attracted the interest of scientific community as they are capable of increasing both penetration depth and imaging quality. However, studies on the utilization of quantum dots (QDs) in biological imaging appear to be rather limited to the near-infrared window I (NIR-I: 650–950 nm). We herein report on the observation of efficient photoluminescence (PL) in Mn2+-doped ZnS QDs excited by two-photon absorption (2PA) in near-infrared window II (NIR-II: 1000–1350 nm). Multiphoton-absorption-induced PL measurements indicate that these biocompatible QDs exhibit a two-photon action cross-section of 265 GM at 1180 nm, the highest value reported to date among conventional fluorescent probes on excitation in NIR-II. This value is 1–2 orders of magnitude higher than that for organic dye molecules excited by NIR-I photons and 3–4 times greater than that of fluorescent proteins excited in the NIR-II. The underlying NIR-II excitation me...

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