IMPACTS STUDY OF METHYLAMINE AVERMECTIN AS A NEW BIOINSECTICIDE AGAINST THE COTTON LEAFWORM Spodoptera littoralis (Boisd.) AND MALE ALBINO RATS

The efficacy of a new semi-synthetic avermectin derivative Methylamine avermectin (Radical 0.5% EC) was evaluated on the larvae of the Egyptian cotton leafworm, Spodoptera littoralis (Boisd): (Lepidoptera: Noctuidae). The 2 nd instar larvae was more sensitive than 4 th instar larvae, the determined LC 50 for 2 nd instar larvae was 0.021 ppm. From the obtained results it was clear that the larval duration, pupal duration, pupal weight , pupation percentage, adult emergence and the number of laid eggs of the 2 nd instar larvae treated with the LC 50 of methylamine avermectin were decreased significantly compared to their control. While, male and female longevity insignificantly affected compared to control. On the other hand, male albino rats were administered oral doses equivalent to 1/10 or 1/40 of the LD 50 value (45mg/kg body weight) for 21 days (day after day), since, methylamine avermectin affect on the biochemical parameters of liver function (i.e. aspartate aminotransferase activity, alanine amino transferase activity, albumin, cholesterol and triglycerides levels), kidney function (urea and creatinine concentration), testes function (testosterone).

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