Targeting Integrins αvβ3 and αvβ5 for Bloking Tumor-Induced Angiogenesis

[1]  N. Kleiman,et al.  Platelet glycoprotein IIb/IIIa antagonists. What are the relevant issues concerning their pharmacology and clinical use? , 1999, Circulation.

[2]  F. Mitjans,et al.  Integrin αVβ3 Promotes M21 Melanoma Growth in Human Skin by Regulating Tumor Cell Survival , 1999 .

[3]  R. Soldi,et al.  Role of αvβ3 integrin in the activation of vascular endothelial growth factor receptor‐2 , 1999, The EMBO journal.

[4]  C. Kumar,et al.  Signaling by integrin receptors , 1998, Oncogene.

[5]  E. Maxwell,et al.  Biochemical Characterization of the Binding of Echistatin to Integrin αvβ3 Receptor , 1997 .

[6]  Chandra L. Theesfeld,et al.  Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[7]  J. Becker,et al.  Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis. , 1996, The Journal of clinical investigation.

[8]  W. Stetler-Stevenson,et al.  Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3 , 1996, Cell.

[9]  D. Cheresh,et al.  Review: The Integrin αvβ3: Angiogenesis and Apoptosis , 1995 .

[10]  F. Sarkar,et al.  Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin. , 1995, The Journal of clinical investigation.

[11]  S. Shattil.  Function and Regulation of the β3 Integrins in Hemostasis and Vascular Biology , 1995, Thrombosis and Haemostasis.

[12]  J. Nip,et al.  Coordinated expression of the vitronectin receptor and the urokinase-type plasminogen activator receptor in metastatic melanoma cells. , 1995, The Journal of clinical investigation.

[13]  D. Cheresh,et al.  Integrin α v β 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels , 1994, Cell.

[14]  John Calvin Reed,et al.  Anchorage dependence, integrins, and apoptosis , 1994, Cell.

[15]  D. Cheresh,et al.  Requirement of vascular integrin alpha v beta 3 for angiogenesis. , 1994, Science.

[16]  J. Tschopp,et al.  Design and synthesis of novel cyclic RGD-containing peptides as highly potent and selective integrin alpha IIb beta 3 antagonists. , 1994, Journal of medicinal chemistry.

[17]  Richard O. Hynes,et al.  Integrins: Versatility, modulation, and signaling in cell adhesion , 1992, Cell.

[18]  J. Folkman,et al.  The role of angiogenesis in tumor growth. , 1992, Seminars in cancer biology.

[19]  M. Hendrix,et al.  Role of the alpha v beta 3 integrin in human melanoma cell invasion. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[20]  V. Garsky,et al.  Proton NMR assignments and secondary structure of the snake venom protein echistatin. , 1991, Biochemistry.

[21]  D. Elder,et al.  Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression. , 1990, Cancer research.

[22]  S. Bodary,et al.  The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line. , 1990, The Journal of biological chemistry.

[23]  S. Bodary,et al.  Expression of recombinant platelet glycoprotein IIbIIIa results in a functional fibrinogen-binding complex. , 1989, The Journal of biological chemistry.

[24]  E Ruoslahti,et al.  RGD and other recognition sequences for integrins. , 1996, Annual review of cell and developmental biology.