Epinephrine, pregnenolone and testosterone in the treatment of rheumatoid arthritis.

Reports of the effectiveness of cortisone (Kendall's compound E, or 17-hydroxy-11-dehydrocorticosterone) and of pituitary adrenocorticotropic hormone (ACTH) in the treatment of rheumatoid arthritis and spondylitis 1 have given rise to the hope that substances known to stimulate endogenous production or liberation of pituitary adrenocorticotropic hormone might also be effective in these conditions. Vogt 2 demonstrated in several different species of animals that the amount of active cortical material released into the suprarenal vein in one minute is many times that which can be extracted from both adrenal cortices by present methods. The administration, of epinephrine was found to increase the amount of cortical material which could be recovered from suprarenal venous blood by several hundred per cent. 3 Her results suggested that epinephrine, administered in doses approaching the amounts that might be liberated normally within the body, stimulates the adrenal cortex directly. Long 4 concluded that the action of epinephrine

[1]  G. W. Thorn,et al.  The diagnosis and treatment of adrenal insufficiency , 1951 .

[2]  Bayles Tb,et al.  Studies on the relation of pituitary-adrenal function to rheumatic disease. , 1949 .

[3]  A. Hellbaum,et al.  The effects of certain steroid compounds on various manifestations of rheumatoid arthritis. , 1949, The Journal of the Oklahoma State Medical Association.

[4]  P. Hench.  Potential Reversibility of Rheumatoid Arthritis * , 1949, Annals of the rheumatic diseases.

[5]  P. Hench,et al.  The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone; compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis. , 1949, Proceedings of the staff meetings. Mayo Clinic.

[6]  J. Laragh,et al.  Reduction in circulating eosinophils following epinephrine, insulin and surgical operations. , 1949, The American journal of medicine.

[7]  J. Strieder.  Surgical aspects of bronchiectasis. , 1948, The New England journal of medicine.

[8]  G. W. Thorn,et al.  Clinical studies with pituitary adrenocorticotropin. , 1948, The Journal of clinical endocrinology and metabolism.

[9]  M. Vogt.  Some aspects of the physiology of the secretion of the adrenal cortex with a bearing on clinical medicine. , 1947, Experimental medicine and surgery.

[10]  C. Long.  Recent Studies on the Function of the Adrenal Cortex. , 1947, Bulletin of the New York Academy of Medicine.

[11]  W. Kuzell,et al.  Excretion of 17-ketosteroids in ankylosing spondylarthritis and in rheumatoid arthritis; a preliminary report. , 1947, The Journal of clinical endocrinology and metabolism.

[12]  M. Vogt.  Observations on some conditions affecting the rate of hormone output by the suprarenal cortex , 1944, The Journal of physiology.

[13]  H Hoagland,et al.  ADVENTURES IN BIOLOGICAL ENGINEERING. , 1944, Science.

[14]  M. Vogt.  The output of cortical hormone by the mammalian suprarenal , 1943, The Journal of physiology.