Lack of association between certain candidate gene polymorphisms and the metabolic syndrome.

[1]  T. Hansen,et al.  The common T60N polymorphism of the lymphotoxin-α gene is associated with type 2 diabetes and other phenotypes of the metabolic syndrome , 2005, Diabetologia.

[2]  L. Groop,et al.  Cardiovascular morbidity and mortality associated with the metabolic syndrome. , 2001, Diabetes care.

[3]  A. Gressner,et al.  Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. , 2004, Clinical chemistry.

[4]  J. Chan,et al.  An insulin receptor gene polymorphism is associated with diastolic blood pressure in Chinese subjects with components of the metabolic syndrome. , 2000, American journal of hypertension.

[5]  Anita L. DeStefano,et al.  Evidence for a Gene Influencing Blood Pressure on Chromosome 17: Genome Scan Linkage Results for Longitudinal Blood Pressure Phenotypes in Subjects From the Framingham Heart Study , 2000, Hypertension.

[6]  L. Groop,et al.  Metabolic Consequences of a Family History of NIDDM (The Botnia Study): Evidence for Sex-Specific Parental Effects , 1996, Diabetes.

[7]  P. Froguel,et al.  An uncoupling protein 3 gene polymorphism associated with a lower risk of developing Type II diabetes and with atherogenic lipid profile in a French cohort , 2000, Diabetologia.

[8]  L. Groop,et al.  Putative role of polymorphisms in UCP1-3 genes for diabetic nephropathy. , 2004, Journal of diabetes and its complications.

[9]  A. Blakemore,et al.  Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product. , 1992, Human molecular genetics.

[10]  K. Xiang,et al.  [Effects of uncoupling protein 3 gene -55 C-->T variant on lipid metabolism, body fat, its distribution and non-insulin-dependent diabetes mellitus in Chinese]. , 2002, Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics.

[11]  J. Chan,et al.  Renin-angiotensin system gene polymorphisms, blood pressure, dyslipidemia, and diabetes in Hong Kong Chinese: a significant association of tne ACE insertion/deletion polymorphism with type 2 diabetes. , 2001, Diabetes care.

[12]  T. Jørgensen,et al.  Studies of the Pro12Ala polymorphism of the ppar-γ gene in the Danish MONICA cohort: Homozygosity of the Ala allele confers a decreased risk of the Insulin Resistance syndrome , 2002 .

[13]  W. Siffert G protein polymorphisms in hypertension, atherosclerosis, and diabetes. , 2005, Annual review of medicine.

[14]  J. P. Warne,et al.  Tumour necrosis factor alpha: a key regulator of adipose tissue mass. , 2003, The Journal of endocrinology.

[15]  H. Lodish,et al.  Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein , 1994, Cell.

[16]  P. Amouyel,et al.  The Gly16-->Arg16 and Gln27-->Glu27 polymorphisms of beta2-adrenergic receptor are associated with metabolic syndrome in men. , 2003, The Journal of clinical endocrinology and metabolism.

[17]  K. Clément,et al.  A polymorphism in the 5′ untranslated region of the human ob gene is associated with low leptin levels , 1998, International Journal of Obesity.

[18]  M. Neale,et al.  Genetic and Environmental Factors in Relative Body Weight and Human Adiposity , 1997, Behavior genetics.

[19]  S. O’Rahilly,et al.  Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population , 2001, International Journal of Obesity.

[20]  M. Laakso,et al.  The Trp64Arg Polymorphism of the β3-Adrenergic Receptor Gene: Lack of association with NIDDM and features of insulin resistance syndrome , 1997, Diabetes Care.

[21]  S. Rössner,et al.  Excessive fat accumulation is associated with the TNFα–308 G/A promoter polymorphism in women but not in men , 2000, Diabetologia.

[22]  P. Arner,et al.  No association of reported functional protein tyrosine phosphatase 1B 3′ UTR gene polymorphism with features of the metabolic syndrome in a Swedish population , 2004, Journal of internal medicine.

[23]  K. Schenck-Gustafsson,et al.  A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution. , 2003, Atherosclerosis.

[24]  B. Tomlinson,et al.  The Trp64Arg polymorphism of the β3-adrenergic receptor gene and obesity in Chinese subjects with components of the metabolic syndrome , 2000, International Journal of Obesity.

[25]  J. O’Connell,et al.  Variation in the Lamin A/C Gene: Associations With Metabolic Syndrome , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[26]  A. Martí,et al.  Influence of two polymorphisms of the tumoral necrosis factor-alpha gene on the obesity phenotype. , 2004, Diabetes, nutrition & metabolism.

[27]  E. Ford,et al.  A comparison of the prevalence of the metabolic syndrome using two proposed definitions. , 2003, Diabetes care.

[28]  A. Maia,et al.  The ACE insertion/deletion polymorphism is not associated with the metabolic syndrome (WHO Definition) in Brazilian type 2 diabetic patients. , 2002, Diabetes care.

[29]  E. Ferrannini,et al.  Hypertension, insulin resistance, and the metabolic syndrome. , 2004, Endocrinology and metabolism clinics of North America.

[30]  D. Gaudet,et al.  Association between the PPARα-L162V polymorphism and components of the metabolic syndrome , 2004, Journal of Human Genetics.

[31]  S. O’Rahilly,et al.  Congenital leptin deficiency is associated with severe early-onset obesity in humans , 1997, Nature.

[32]  M. Laakso,et al.  Variation in the fatty acid binding protein 2 gene is not associated with markers of metabolic syndrome in patients with coronary heart disease. , 2002, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[33]  K. Clément,et al.  A genetic variation in the 5 ′ flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity , 2000, Diabetologia.

[34]  J. Chan,et al.  Tumor necrosis factor alpha gene G-308A polymorphism in the metabolic syndrome. , 2000, Metabolism: clinical and experimental.

[35]  B. Balkau,et al.  Comment on the provisional report from the WHO consultation , 1999, Diabetic medicine : a journal of the British Diabetic Association.

[36]  H. Snieder,et al.  Dissecting the Genetic Architecture of Lipids, Lipoproteins, and Apolipoproteins Lessons from Twin Studies Developmental Trends Trends in Means Brief Reviews , 2022 .

[37]  J. Tsai,et al.  ACE gene insertion/deletion polymorphism associated with 1998 World Health Organization definition of metabolic syndrome in Chinese type 2 diabetic patients. , 2002, Diabetes care.

[38]  Alan E. Jackson,et al.  Evidence that single nucleotide polymorphism in the uncoupling protein 3 (UCP3) gene influences fat distribution in women of European and Asian origin , 2000, Diabetologia.

[39]  K. Kohara,et al.  Association of GNB3 gene with pulse pressure and clustering of risk factors for cardiovascular disease in Japanese. , 2004, Biochemical and biophysical research communications.

[40]  J. Auwerx,et al.  Intronic polymorphism in the fatty acid transport protein 1 gene is associated with increased plasma triglyceride levels in a French population. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[41]  T. Jørgensen,et al.  Studies of the Gly482Ser polymorphism of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) gene in Danish subjects with the metabolic syndrome , 2005 .

[42]  F. Sestier,et al.  Metabolic syndrome X: a review. , 2000, The Canadian journal of cardiology.

[43]  H. Lodish,et al.  Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes. , 2002, Developmental cell.

[44]  E. Ravussin,et al.  A novel polymorphism in the proximal UCP3 promoter region: effect on skeletal muscle UCP3 mRNA expression and obesity in male non-diabetic Pima Indians , 1999, International Journal of Obesity.

[45]  P. Amouyel,et al.  The human G-protein beta3 subunit C825T polymorphism is associated with coronary artery vasoconstriction. , 2001, European heart journal.

[46]  A. Strosberg,et al.  A leptin missense mutation associated with hypogonadism and morbid obesity , 1998, Nature Genetics.

[47]  Jukka T Salonen,et al.  The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. , 2002, JAMA.

[48]  R. Hamman,et al.  Genetic variation in uncoupling protein 3 is associated with dietary intake and body composition in females. , 2004, Metabolism: clinical and experimental.

[49]  David J. Moliterno,et al.  Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients , 2003, Human Genetics.

[50]  T. Hansen,et al.  Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes , 2005, Diabetologia.