Investigation of in vitro anti-arthritic and membrane stabilizing activity of ethanol extracts of three Bangladeshi plants

Three Bangladeshi medicinal plants Rhaphidophora glauca, Phrynium imbricatum, Steudnera colocasiifolia, have been investigated for their in vitro Arthritic and membrane stabilizing activity. Inhibition proteinase actions were evaluated to assess the antiarthritic effect of the selected plant extracts and membrane stabilizing activity were assessed by using hypotonic solution and heat-induced method. In highest concentration of Rhaphidophora glauca, Phrynium imbricatum, Steudnera colocasiifolia, shows significant antiarthritic activity (53.16%, 69.62%, 62.03%) and membrane stabilizing activity (49.05%, 71.9%, 60.22%) compared with Diclofenac-Na. Further in depth studies on this plant can result in an eco-friendly cost effective antiarthritic herbal drug with anti-inflammatory potential contributing towards the better healthcare of human society.

[1]  Z. A. Bhat,et al.  Evaluation of anti-inflammatory potential of leaf extracts of Skimmia anquetilia. , 2012, Asian Pacific journal of tropical biomedicine.

[2]  S. Bhattacharya,et al.  Evaluation of anti-inflammatory effect of Ashwagandha: a preliminary study in vitro. , 2012 .

[3]  C. Dilip,et al.  Anti-inflammatory activity of the glandular extracts of Thunnus alalunga. , 2010 .

[4]  S. D. Quine,et al.  Evaluation of Anti-inflammatory and Membrane stabilizing property of Ethanol Extract of Cansjera rheedii J.Gmelin (Opiliaceae) , 2008 .

[5]  D. Wendling,et al.  The contribution of adipose tissue and adipokines to inflammation in joint diseases. , 2007, Current medicinal chemistry.

[6]  L. Picker,et al.  Lymphocyte Homing and Homeostasis , 1996, Science.

[7]  M. Sporn,et al.  Peptide Growth Factors and Inflammation, Tissue Repair, and Cancer , 1987 .

[8]  G. Mishra,et al.  Anti-arthritic activity of Glycyrrhiza glabra, Boswellia serrata and their synergistic activity in combined formulation studied in freund's adjuvant induced arthritic rats , 2011 .

[9]  Y. Shivhare,et al.  In-vitro Anti-arthritic Activity of Manilkara zapota Linn , 2011 .

[10]  C. Uma,et al.  In-vitro Anti-inflammatory and Anti-arthritic Activity of Leaves of Cleodendron Inerme , 2011 .

[11]  R. Lavanya,et al.  Investigation of In-vitro anti-Inflammatory, anti-platelet and anti-arthritic activities in the leaves of Anisomeles malabarica Linn , 2010 .

[12]  O. James,et al.  In vitro and in vivo studies on the antioxidative activities, membrane stabilization and cytotoxicity of water spinach (Ipomoea aquatica Forsk) from Ibaji Ponds, Nigeria. , 2009 .