Too smart to fail-how viruses exploit the complexity of host cells during entry.

Francois-Loic Cosset is a virologist from the National Center of Scientific Research (CNRS) at the Human Virology Department (Inserm U758) of the ENS of Lyon, France. His recent work concentrates on the assembly and entry of enveloped viruses, notably retroviruses and hepatitis C virus, and on the engineering of gene delivery vectors derived from pseudotyped lentiviruses. Viruses are multivalent particles built of repetitively arranged proteins and sometimes sugars and lipids. They have various shapes and sizes ranging from dozens of nano-meters to micro-meters. Small viruses contain a minimal set of genes encoding structural and regulatory proteins and sometimes micro-RNAs, while large viruses have in addition complex genomes of hundreds of thousands of nucleotides.

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